ES444346A1 - Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES444346A1 ES444346A1 ES444346A ES444346A ES444346A1 ES 444346 A1 ES444346 A1 ES 444346A1 ES 444346 A ES444346 A ES 444346A ES 444346 A ES444346 A ES 444346A ES 444346 A1 ES444346 A1 ES 444346A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- procedure
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001253 acrylic acids Chemical class 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000003637 basic solution Substances 0.000 abstract 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCEDURE FOR OBTAINING NEW ACILEFALOSPORINS", characterized essentially because it consists of separately obtaining 7-ACA, 7-ADCA, cephalexin and substituted 7-ACA-3 acids, dissolving them or suspending them in an aqueous or organic aqueous medium, adding an ion scavenger hydrogen to react the set with acrylic acids -3- substituted in their reactive forms, the reaction temperature being between -30 and 70º C while its duration is a function of the permanence of the reagents, making the control of the course of the reaction by conventional means until a basic solution is obtained which is acidified with inorganic acids and finally extracted with an organic solvent from which the final product is isolated by evaporation. (Machine-translation by Google Translate, not legally binding)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES444346A ES444346A1 (en) | 1976-01-15 | 1976-01-15 | Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding) |
| DE2657652A DE2657652C3 (en) | 1976-01-15 | 1976-12-20 | N-acyl derivatives of cefalexin and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES444346A ES444346A1 (en) | 1976-01-15 | 1976-01-15 | Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES444346A1 true ES444346A1 (en) | 1977-10-01 |
Family
ID=8470734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES444346A Expired ES444346A1 (en) | 1976-01-15 | 1976-01-15 | Procedure for obtaining new acilefalosporines. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2657652C3 (en) |
| ES (1) | ES444346A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1022544A (en) * | 1972-12-21 | 1977-12-13 | Yukiyasu Murakami | Process of preparing a heterocyclic acyl group-substituted cephalosporin derivative |
-
1976
- 1976-01-15 ES ES444346A patent/ES444346A1/en not_active Expired
- 1976-12-20 DE DE2657652A patent/DE2657652C3/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2657652C3 (en) | 1982-04-08 |
| DE2657652B2 (en) | 1981-04-23 |
| DE2657652A1 (en) | 1977-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |