ES446571A1 - Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. - Google Patents

Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina.

Info

Publication number: ES446571A1
Authority: ES; Spain
Prior art keywords: alq; hydrogen; formula; alkyl; cycloalq
Prior art date: 1973-04-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES446571A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1976-03-31

Publication date

1977-06-16

1976-03-31 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1977-06-16 Publication of ES446571A1 publication Critical patent/ES446571A1/es

Status Expired legal-status Critical Current

Links

229940122803 Vinca alkaloid Drugs 0.000 title 1
150000003797 alkaloid derivatives Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000001540 azides Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
JXLYSJRDGCGARV-PJXZDTQASA-N Leurosidine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-PJXZDTQASA-N 0.000 abstract 1
JXLYSJRDGCGARV-KSNABSRWSA-N ac1l29ym Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-KSNABSRWSA-N 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000005518 carboxamido group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
-1 cyano, phenyl Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
229960003048 vinblastine Drugs 0.000 abstract 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical class C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ES446571A 1973-04-02 1976-03-31 Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. Expired ES446571A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (1)

Publication Number	Publication Date
ES446571A1 true ES446571A1 (es)	1977-06-16

Family

ID=23363051

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES424882A Expired ES424882A1 (es)	1973-04-02	1974-04-02	Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina.
ES446571A Expired ES446571A1 (es)	1973-04-02	1976-03-31	Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES424882A Expired ES424882A1 (es)	1973-04-02	1974-04-02	Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina.

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (es)
AR (2)	AR204004A1 (es)
AT (1)	AT340605B (es)
BE (1)	BE813168A (es)
BG (3)	BG22831A3 (es)
CA (1)	CA1042428A (es)
CH (1)	CH603669A5 (es)
CS (1)	CS185223B2 (es)
CY (1)	CY1044A (es)
DD (1)	DD113538A5 (es)
DE (1)	DE2415980A1 (es)
DK (1)	DK141511B (es)
ES (2)	ES424882A1 (es)
FR (1)	FR2223044B1 (es)
GB (1)	GB1463575A (es)
HK (1)	HK20180A (es)
HU (1)	HU171572B (es)
IE (1)	IE39071B1 (es)
IL (1)	IL44415A (es)
KE (1)	KE3028A (es)
MY (1)	MY8100025A (es)
NL (1)	NL181079C (es)
PH (1)	PH13623A (es)
RO (2)	RO73524B (es)
SE (1)	SE416206B (es)
SU (4)	SU731900A3 (es)
YU (3)	YU39719B (es)
ZA (1)	ZA741674B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (es) *	1976-09-08	1982-07-07	Lilly Co Eli
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4210584A (en)	1979-01-15	1980-07-01	Eli Lilly And Company	Vindesine synthesis
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr)	1981-12-08	1983-09-01	Omnichem Sa	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
OA06421A (fr) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FR2623504B1 (fr) *	1987-11-25	1990-03-09	Adir	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
US20080161251A1 (en)	2005-01-21	2008-07-03	Astex Therapeutics Limited	Pharmaceutical Compounds
RU2447889C2 (ru)	2005-07-18	2012-04-20	Бипар Сайенсиз, Инк.	Способ лечения рака (варианты)
CN101522609A (zh)	2006-09-05	2009-09-02	彼帕科学公司	癌症的治疗
CA2662337A1 (en)	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044045A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
JP2011503111A (ja)	2007-11-12	2011-01-27	バイパーサイエンシズ，インコーポレイティド	Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
AU2014253584B2 (en) *	2013-04-19	2017-02-02	Jinan University	Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (zh) *	2021-06-18	2024-03-08	暨南大学	长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 BG BG026279A patent/BG22831A3/xx unknown
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 BG BG028514A patent/BG21235A3/xx unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/xx unknown
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired

Also Published As

Publication number	Publication date
DK141511B (da)	1980-04-08
IE39071B1 (en)	1978-08-02
DE2415980C2 (es)	1989-11-09
AR204004A1 (es)	1975-11-12
FR2223044A1 (es)	1974-10-25
BE813168A (fr)	1974-10-02
NL7404423A (es)	1974-10-04
JPS6033837B2 (ja)	1985-08-05
HK20180A (en)	1980-04-25
YU39875B (en)	1985-04-30
IL44415A0 (en)	1974-06-30
YU39876B (en)	1985-04-30
JPS5919117B2 (ja)	1984-05-02
CS185223B2 (en)	1978-09-15
ZA741674B (en)	1975-10-29
NL181079B (nl)	1987-01-16
KE3028A (en)	1980-03-28
CA1042428A (en)	1978-11-14
YU113880A (en)	1982-05-31
RO77533A (ro)	1982-02-01
DK141511C (es)	1980-09-29
AR203882A1 (es)	1975-10-31
CY1044A (en)	1980-08-01
DE2415980A1 (de)	1974-10-10
SU623522A3 (ru)	1978-09-05
YU81774A (en)	1982-05-31
BG21612A3 (bg)	1976-07-20
SU784783A3 (ru)	1980-11-30
SE416206B (sv)	1980-12-08
SU731900A3 (ru)	1980-04-30
MY8100025A (en)	1981-12-31
ES424882A1 (es)	1976-12-16
GB1463575A (en)	1977-02-02
IL44415A (en)	1978-08-31
BG21235A3 (bg)	1976-03-20
IE39071L (en)	1974-10-02
BG22831A3 (bg)	1977-04-20
SU652896A3 (ru)	1979-03-15
AU6671974A (en)	1975-09-18
ATA267974A (de)	1977-04-15
DD113538A5 (es)	1975-06-12
PH13623A (en)	1980-08-07
RO73524B (ro)	1984-11-30
NL181079C (nl)	1987-06-16
AT340605B (de)	1977-12-27
RO73524A (ro)	1984-10-31
FR2223044B1 (es)	1978-06-30
HU171572B (hu)	1978-02-28
YU113980A (en)	1982-05-31
CH603669A5 (es)	1978-08-31
YU39719B (en)	1985-04-30
JPS59193895A (ja)	1984-11-02
JPS49128000A (es)	1974-12-07

Legal Events

Date	Code	Title	Description
2007-02-16	FD1A	Patent lapsed	Effective date: 19970315

Publication	Publication Date	Title
ES424882A1 (es)	1976-12-16	Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina.
IE41528L (en)	1975-04-27	Furfuryl-benzomorphane derivatives.
ES394370A1 (es)	1974-11-16	Procedimiento para la preparacion de derivados de la inso-indolina.
ES413639A1 (es)	1976-01-16	Un procedimiento para la preparacion de un compuesto deri- vado de dopamina.
ES393801A1 (es)	1974-07-01	Un procedimiento para la preparacion de compuestos semisin-teticos utilizados en la produccion de cefalosporinas, peni-cilinas y compuestos antibioticos relacionados de beta-lac- tama.
ES439909A1 (es)	1977-08-16	Procedimiento para la preparacion de derivados s-2-tiol-4,5-difeniloxazol.
ES411038A1 (es)	1975-12-01	Un procedimiento para la preparacion de compuestos semisin-teticos intermedios en la produccion de cefalosporinas, pe- nicilinas y antibioticos relacionados de beta-lactama.
SE7603951L (sv)	1976-10-04	Forfarande for framstellning av 7-alfa-(4-hydroci-1,5-nafthydrin-3karbonamido)alfa-fenylacetamido-cefalosporinderivat
ES479570A1 (es)	1979-12-01	Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina.
ES423699A1 (es)	1977-06-16	Procedimiento para la preparacion de acido amino-3-oxi-imi- nometil-3-cefem-4-carboxilico protegido en la posicion.
SE7710059L (sv)	1978-03-09	Forfarande for framstellning av amidderivat vinblastin, av leurosidin, leurokristin och beslektade dimera alkaloider
ES395958A1 (es)	1977-02-01	Un procedimiento para la produccion de un parahidroxifenil -alfa- aminoacido.
ES438704A1 (es)	1977-06-01	Procedimiento para preparar derivados de ergopectina.
ES419142A1 (es)	1976-07-16	Procedimiento para preparar derivados de tioseudourea.
ES447615A1 (es)	1977-10-01	Un procedimiento para obtener compuesto de cefalosporina.
ES418841A1 (es)	1976-03-16	Procedimiento para la obtencion de derivados del acido pi- ridin-3-acetico.
ES393554A1 (es)	1974-11-16	Un procedimiento para la preparacion de derivados de tia- zol.
ES421569A1 (es)	1976-07-16	Un procedimiento para la preparacion de 5,8 - dihidro - 5,8- metanonaftalenos.
ES438658A1 (es)	1977-06-16	Un procedimiento para la preparacion de nuevos derivados de penicilina.
ES432790A1 (es)	1977-02-16	Un metodo para producir derivados del acido 2-cloropropioni-co.
ES414340A1 (es)	1976-05-16	Procedimiento de preparacion de derivados de la n-(m-tri- fluormetiltio-fenil-)-piperazina.
ES444483A1 (es)	1977-07-01	Un procedimiento de preparacion de nuevos derivados de acido2,3-alquilen (inferior) penam-3-carboxilico.
ES441029A1 (es)	1977-03-01	Procedimiento de preparacion de un nuevo derivado del acido acetilsalicilico.
ES343093A1 (es)	1968-08-16	Procedimiento para la obtencion de derivados de 2-imidazo- lidona.
ES454421A1 (es)	1978-10-16	Procedimiento para preparar derivados de acetamidoxina.