ES448220A1 - Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. - Google Patents

Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona.

Info

Publication number
ES448220A1
ES448220A1 ES448220A ES448220A ES448220A1 ES 448220 A1 ES448220 A1 ES 448220A1 ES 448220 A ES448220 A ES 448220A ES 448220 A ES448220 A ES 448220A ES 448220 A1 ES448220 A1 ES 448220A1
Authority
ES
Spain
Prior art keywords
dien
fluoro
preparing
crystalline compound
zsopropili
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES448220A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES448220A1 publication Critical patent/ES448220A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
ES448220A 1975-05-27 1976-05-25 Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. Expired ES448220A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130175A 1975-05-27 1975-05-27
US58130075A 1975-05-27 1975-05-27

Publications (1)

Publication Number Publication Date
ES448220A1 true ES448220A1 (es) 1977-11-01

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES448220A Expired ES448220A1 (es) 1975-05-27 1976-05-25 Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona.

Country Status (15)

Country Link
JP (1) JPS51144719A (2)
AT (1) AT357702B (2)
AU (1) AU506080B2 (2)
CA (1) CA1075228A (2)
DE (2) DE2661037C2 (2)
ES (1) ES448220A1 (2)
FR (1) FR2361900A1 (2)
GB (1) GB1525181A (2)
HK (1) HK8580A (2)
IL (1) IL49652A (2)
MX (1) MX3864E (2)
MY (1) MY8000275A (2)
NL (1) NL191234C (2)
NZ (1) NZ180946A (2)
SE (1) SE421426B (2)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK162530C (da) * 1979-05-21 1992-03-30 Syntex Corp Fremgangsmaade til fremstilling af en krystallinsk modifikation af flunisolid
ATE3774T1 (de) * 1980-05-02 1983-06-15 Schering Corporation Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung.
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
HU209603B (en) * 1988-10-05 1994-09-28 Upjohn Co Process for production of solid powders in finalydivided microcristallin form
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
IL122752A (en) * 1995-06-27 2001-07-24 Boehringer Ingelheim Kg Stable preparations for creating propellant-free sprays
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
NZ514442A (en) * 1999-03-03 2003-08-29 Optinose As Nasal delivery device
IT1313553B1 (it) * 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
JP5392880B2 (ja) 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
ES2222294T3 (es) 2001-07-02 2005-02-01 Chiesi Farmaceutici S.P.A. Formulacion optimizada de tobramicina para administracion en forma de aerosol.
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
CA2905587A1 (en) * 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
GB933868A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Process for fluorinating steroids
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (fr) * 1969-04-01 1971-01-08 Syntex Corp Composition anti-inflammatoire locale et son mode d'utilisation
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
IL49652A (en) 1979-05-31
MY8000275A (en) 1980-12-31
NZ180946A (en) 1978-07-28
NL7605699A (nl) 1976-11-30
NL191234B (nl) 1994-11-01
DE2624924C2 (de) 1986-11-27
AU506080B2 (en) 1979-12-13
DE2661037C2 (2) 1989-04-06
FR2361900A1 (fr) 1978-03-17
CA1075228A (en) 1980-04-08
AT357702B (de) 1980-07-25
IL49652A0 (en) 1976-07-30
FR2361900B1 (2) 1979-04-13
SE7605927L (sv) 1976-11-28
HK8580A (en) 1980-03-14
AU1430176A (en) 1977-12-01
JPS51144719A (en) 1976-12-13
SE421426B (sv) 1981-12-21
ATA388376A (de) 1979-12-15
GB1525181A (en) 1978-09-20
DE2624924A1 (de) 1977-12-15
JPS6247880B2 (2) 1987-10-09
MX3864E (es) 1981-08-26
NL191234C (nl) 1995-04-03

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