ES448220A1 - Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. - Google Patents

Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona.

Info

Publication number
ES448220A1
ES448220A1 ES448220A ES448220A ES448220A1 ES 448220 A1 ES448220 A1 ES 448220A1 ES 448220 A ES448220 A ES 448220A ES 448220 A ES448220 A ES 448220A ES 448220 A1 ES448220 A1 ES 448220A1
Authority
ES
Spain
Prior art keywords
dien
fluoro
preparing
crystalline compound
zsopropili
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES448220A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES448220A1 publication Critical patent/ES448220A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
ES448220A 1975-05-27 1976-05-25 Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona. Expired ES448220A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (1)

Publication Number Publication Date
ES448220A1 true ES448220A1 (es) 1977-11-01

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES448220A Expired ES448220A1 (es) 1975-05-27 1976-05-25 Un procedimiento para preparar un compuesto cristalino 6 al-fa, fluoro-11 beta, 21-hihidroxi-16 alfa, 17alfa-zsopropili-dendioxipregna-1,4-dien-3,20-diona.

Country Status (15)

Country Link
JP (1) JPS51144719A (fr)
AT (1) AT357702B (fr)
AU (1) AU506080B2 (fr)
CA (1) CA1075228A (fr)
DE (2) DE2624924C2 (fr)
ES (1) ES448220A1 (fr)
FR (1) FR2361900A1 (fr)
GB (1) GB1525181A (fr)
HK (1) HK8580A (fr)
IL (1) IL49652A (fr)
MX (1) MX3864E (fr)
MY (1) MY8000275A (fr)
NL (1) NL191234C (fr)
NZ (1) NZ180946A (fr)
SE (1) SE421426B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60128A (en) * 1979-05-21 1984-01-31 Syntex Corp Preparation of a unique crystalline form of flunisolide
EP0039369B1 (fr) * 1980-05-02 1983-06-15 Schering Corporation Solvats d'esters de béclométhasone, procédé pour leur préparation et préparation d'une formulation
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE68907062T2 (de) * 1988-10-05 1993-10-07 Upjohn Co Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel.
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
BR9609307B1 (pt) * 1995-06-27 2010-03-09 preparação farmacêutica para produção de aerossóis inaláveis isentos de propelentes para administração nos pulmões, bem como aerossol compreendendo a mesma.
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
NZ514442A (en) * 1999-03-03 2003-08-29 Optinose As Nasal delivery device
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
EE05167B1 (et) 2000-05-22 2009-06-15 Chiesi Farmaceutici S.P.A. Stabiilsed farmatseutilised lahuspreparaadid survestatud doseerivatele inhalaatoritele
ES2222294T3 (es) 2001-07-02 2005-02-01 Chiesi Farmaceutici S.P.A. Formulacion optimizada de tobramicina para administracion en forma de aerosol.
JP5238779B2 (ja) * 2003-04-25 2013-07-17 ロート製薬株式会社 点鼻剤
JP4632687B2 (ja) * 2003-04-25 2011-02-16 ロート製薬株式会社 点鼻剤
EP1595531A1 (fr) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Formulation d'une solution pharmaceutique stable pour aérosols doseurs sous pression
CA2905587A1 (fr) 2013-03-15 2014-09-18 Medicis Pharmaceutical Corporation Compositions topiques de flunisolide et methodes de traitement

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids
US3282791A (en) * 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
FR2038105A1 (fr) * 1969-04-01 1971-01-08 Syntex Corp Composition anti-inflammatoire locale et son mode d'utilisation
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (de) * 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verwendung von Kortikoid-Wirkstoffen zur Inhalationstherapie
US3934013A (en) * 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
AT357702B (de) 1980-07-25
NL191234B (nl) 1994-11-01
IL49652A (en) 1979-05-31
SE421426B (sv) 1981-12-21
FR2361900B1 (fr) 1979-04-13
DE2624924C2 (de) 1986-11-27
MX3864E (es) 1981-08-26
SE7605927L (sv) 1976-11-28
JPS51144719A (en) 1976-12-13
DE2661037C2 (fr) 1989-04-06
JPS6247880B2 (fr) 1987-10-09
IL49652A0 (en) 1976-07-30
HK8580A (en) 1980-03-14
MY8000275A (en) 1980-12-31
AU506080B2 (en) 1979-12-13
DE2624924A1 (de) 1977-12-15
NL7605699A (nl) 1976-11-30
CA1075228A (fr) 1980-04-08
ATA388376A (de) 1979-12-15
GB1525181A (en) 1978-09-20
AU1430176A (en) 1977-12-01
FR2361900A1 (fr) 1978-03-17
NZ180946A (en) 1978-07-28
NL191234C (nl) 1995-04-03

Similar Documents

Publication Publication Date Title
NL7611711A (nl) Werkwijze ter bereiding van 9(alpha)-hydroxyandrosteen- dion.
NL190610B (nl) Werkwijze ter bereiding van een entcopolymeren bevattende smeermiddelsamenstelling.
NL7703969A (nl) Werkwijze ter bereiding van syn-isomeren van 3,7-di-gesubstitueerde 3-cefem-4-carbonzuur- verbindingen.
FR2301503A1 (fr) Procede de preparation de 1 alpha, 25-dihydroxycholecalciferol
YU40802B (en) New process for producing substituted 1,2,3,5 tetrahydromiozo (2,1-b) guinazoline-2-one
YU291380A (en) Process for obtaining 6 alpha, 9 alpha-difluoro-16-methyl-predinisolone-17,21-esters
EG12409A (en) Process for preparing of 1-3,3,3-triarylpropyl-4-phenyl-4-piperidinemethanols compounds used as anti diarrheal
ES505669A0 (es) Procedimiento para la isomerizacion de derivados de ergolina
JPS52120131A (en) Treating composition for rercholesterol disease
JPS5225759A (en) Process for preparing 4*44dihydroxyy 3*3**5*5**tetraalkylldiphenyl alkane
NL7607922A (nl) Werkwijze ter bereiding van (alpha).(beta)-ethenisch onver- zadigde aldehyden.
PT65763B (en) Process for regulating plantgrowth
GB1543474A (en) Process for the preparation of cholesta-5,7-diene-3beta,25diol or cholesta-5,7-diene-1alpha,3beta,25-triol
HU174079B (hu) Gajka k sharikomu vintu
ZA765536B (en) Method for the preparation of 2-alkyl indanes
NL7610776A (nl) Werkwijze ter bereiding van alkaanpolyolen.
GB1545813A (en) Control rod assembly for nuclear reactor
NL7604406A (nl) Werkwijze ter bereiding van 3,5-xylenol.
JPS51117028A (en) Record material
NL7606008A (nl) Werkwijze ter bereiding van somatostatine- -analogen.
FR2336413A1 (fr) Nouveau procede de preparation du 3,17b-dihydroxy 7-oxo-estra 1,3,5(10)-triene
AR219914A1 (es) Procedimiento para preparar compuestos 1-tiazolin -2- il) -2- amino-5(6)-sustituido-benzimidazol
PT66336A (en) Process for preparing 1-tertiary-alkyl-3-(furil substituted)with effect anti-hipertensif
JPS52154986A (en) Inspection method for grid spacer
JPS5214997A (en) Method for replacing master cam in cam grinders