ES449771A1 - Procedimiento de preparacion de una nueva sustancia antitu- moral basica designada por el numero 32.999 rp. - Google Patents
Procedimiento de preparacion de una nueva sustancia antitu- moral basica designada por el numero 32.999 rp.Info
- Publication number
- ES449771A1 ES449771A1 ES449771A ES449771A ES449771A1 ES 449771 A1 ES449771 A1 ES 449771A1 ES 449771 A ES449771 A ES 449771A ES 449771 A ES449771 A ES 449771A ES 449771 A1 ES449771 A1 ES 449771A1
- Authority
- ES
- Spain
- Prior art keywords
- redn
- deriv
- carminomycin
- naphthacene
- prepd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229930188550 carminomycin Natural products 0.000 title abstract 2
- XREUEWVEMYWFFA-CSKJXFQVSA-N carminomycin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XREUEWVEMYWFFA-CSKJXFQVSA-N 0.000 title abstract 2
- XREUEWVEMYWFFA-UHFFFAOYSA-N carminomycin I Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=C(O)C=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XREUEWVEMYWFFA-UHFFFAOYSA-N 0.000 title abstract 2
- 229950001725 carubicin Drugs 0.000 title abstract 2
- IFLREYGFSNHWGE-UHFFFAOYSA-N tetracene Chemical compound C1=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C21 IFLREYGFSNHWGE-UHFFFAOYSA-N 0.000 title abstract 2
- 241000187747 Streptomyces Species 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procedimiento de preparación de una nueva sustancia antitumoral básica, designada por el número 32.999 RP, de fórmula: **(Fórmula)** en forma de base libre o de sal de adición con un ácido, caracterizado porque se cultiva Streptomyces atroviolaceus DS 9839 (NRRL 8148) o sus mutantes productores en un medio nutritivo aireado que contiene fuentes de carbono y de nitrógeno asimilables y sales minerales a un pH inicial de 5,8 y 7,8 y a una temperatura de 23 a 33ºC y después se extrae el antibiótico del medio de cultivo, por un disolvente orgánico, purificante por cromatografía o cristalización y, eventualmente se transforma la base en sal de adición con un ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7602912A FR2340096A2 (fr) | 1976-02-03 | 1976-02-03 | Nouveau derive du naphtacene, sa preparation et les compositions qui le contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449771A1 true ES449771A1 (es) | 1978-02-16 |
Family
ID=9168690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES449771A Expired ES449771A1 (es) | 1976-02-03 | 1976-07-12 | Procedimiento de preparacion de una nueva sustancia antitu- moral basica designada por el numero 32.999 rp. |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES449771A1 (es) |
| FR (1) | FR2340096A2 (es) |
-
1976
- 1976-02-03 FR FR7602912A patent/FR2340096A2/fr active Granted
- 1976-07-12 ES ES449771A patent/ES449771A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2340096B2 (es) | 1979-09-14 |
| FR2340096A2 (fr) | 1977-09-02 |
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