ES453582A2 - Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof - Google Patents
Tetrahydropyridine and piperidine derivatives and processes for the preparation thereofInfo
- Publication number
- ES453582A2 ES453582A2 ES453582A ES453582A ES453582A2 ES 453582 A2 ES453582 A2 ES 453582A2 ES 453582 A ES453582 A ES 453582A ES 453582 A ES453582 A ES 453582A ES 453582 A2 ES453582 A2 ES 453582A2
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydropyridine
- processes
- preparation
- piperidine derivatives
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- WZXHSWVDAYOFPE-UHFFFAOYSA-N brofaromine Chemical compound C=1C2=CC(OC)=CC(Br)=C2OC=1C1CCNCC1 WZXHSWVDAYOFPE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000006965 reversible inhibition Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The novel 4-(7-bromo-5-methoxy-2-benzofuranyl)piperidine of the formula < IMAGE > is prepared by solvolysis of derivatives thereof which contain on the nitrogen atom an appropriate group which can be replaced by hydrogen. The compound of the formula I can be converted into its acid addition salts. These new substances have pharmacological properties characteristic of antidepressants the selective, reversible inhibition of the A form of monoamine oxidase should be particularly emphasised.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1530175A CH609054A5 (en) | 1975-11-26 | 1975-11-26 | Process for the preparation of a novel piperidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453582A2 true ES453582A2 (en) | 1978-01-01 |
Family
ID=4407989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453582A Expired ES453582A2 (en) | 1975-11-26 | 1976-11-24 | Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5265277A (en) |
| AR (1) | AR214985A1 (en) |
| AT (1) | AT352728B (en) |
| AU (1) | AU507722B2 (en) |
| BE (1) | BE848720R (en) |
| CA (1) | CA1088940A (en) |
| CH (1) | CH609054A5 (en) |
| CS (2) | CS205049B2 (en) |
| CY (1) | CY1179A (en) |
| DD (1) | DD129328A6 (en) |
| DE (1) | DE2653147A1 (en) |
| DK (1) | DK142987C (en) |
| ES (1) | ES453582A2 (en) |
| FR (1) | FR2332754A2 (en) |
| GB (1) | GB1565055A (en) |
| HK (1) | HK16783A (en) |
| IE (1) | IE44084B1 (en) |
| MY (1) | MY8400093A (en) |
| NL (1) | NL7613050A (en) |
| NZ (1) | NZ182716A (en) |
| SE (1) | SE426826B (en) |
| SU (3) | SU679136A3 (en) |
| ZA (1) | ZA777068B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006524A1 (en) | 1978-06-22 | 1980-01-09 | Ciba-Geigy Ag | Tetrahydropyridine and tetrahydropiperidine derivatives, their acid addition salts, processes for their preparation and pharmaceutical compositions containing them |
| US5455254A (en) * | 1991-02-15 | 1995-10-03 | Mondadori; Cesare | Substituted benzofuranylpiperidine as a nootropic agent |
| RU2095339C1 (en) * | 1991-10-17 | 1997-11-10 | Циба-Гейги АГ | Hydroquinone derivatives as free or salt, methods of their synthesis, piperidine derivatives and methods of their synthesis |
| US5693807A (en) * | 1992-10-14 | 1997-12-02 | Ciba-Geigy Corporation | Substituted hydroquinone derivatives |
| ATE180780T1 (en) * | 1993-08-05 | 1999-06-15 | Hoechst Marion Roussel Inc | 2-(PIPERIDINE-4-YL, PYRIDINE-4-YL AND TETRAHYDROPYRIDINE-4-YL)-BENZOFURAN-7-CARBAMAT DERIVATIVES, THEIR PREPARATION AND USE AS ACETYLCHOLINESTERASE INHIBITORS |
| CN101810606A (en) * | 2010-03-12 | 2010-08-25 | 南方医科大学 | Application of 2-(6-hydroxyl-2',3'-dimethoxyphenyl)-6-hydroxyl-7-methoxy benzofuran for preparing monoamine oxidase inhibitor |
| CN103037694B (en) | 2010-06-23 | 2014-08-13 | 住友化学株式会社 | Composition and heterocyclic compound for controlling harmful arthropods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH592656A5 (en) * | 1973-03-02 | 1977-10-31 | Ciba Geigy Ag | |
| IE39264B1 (en) * | 1973-05-25 | 1978-08-30 | Ciba Geigy Ag | New pharmaceutical preparations |
-
1975
- 1975-11-26 CH CH1530175A patent/CH609054A5/en not_active IP Right Cessation
-
1976
- 1976-11-22 AR AR265561A patent/AR214985A1/en active
- 1976-11-23 NL NL7613050A patent/NL7613050A/en not_active Application Discontinuation
- 1976-11-23 DE DE19762653147 patent/DE2653147A1/en active Granted
- 1976-11-23 CY CY1179A patent/CY1179A/en unknown
- 1976-11-23 GB GB48763/76A patent/GB1565055A/en not_active Expired
- 1976-11-24 FR FR7635373A patent/FR2332754A2/en active Granted
- 1976-11-24 CA CA266,466A patent/CA1088940A/en not_active Expired
- 1976-11-24 DD DD7600195944A patent/DD129328A6/en unknown
- 1976-11-24 ES ES453582A patent/ES453582A2/en not_active Expired
- 1976-11-25 SE SE7613193A patent/SE426826B/en not_active IP Right Cessation
- 1976-11-25 BE BE172674A patent/BE848720R/en not_active IP Right Cessation
- 1976-11-25 IE IE2588/76A patent/IE44084B1/en unknown
- 1976-11-25 ZA ZA00777068A patent/ZA777068B/en unknown
- 1976-11-25 DK DK532176A patent/DK142987C/en active
- 1976-11-25 AU AU19995/76A patent/AU507722B2/en not_active Expired
- 1976-11-25 CS CS767637A patent/CS205049B2/en unknown
- 1976-11-25 SU SU762422953A patent/SU679136A3/en active
- 1976-11-25 CS CS767637A patent/CS205050B2/en unknown
- 1976-11-25 AT AT874476A patent/AT352728B/en not_active IP Right Cessation
- 1976-11-25 NZ NZ182716A patent/NZ182716A/en unknown
- 1976-11-26 JP JP51141389A patent/JPS5265277A/en active Granted
-
1978
- 1978-04-17 SU SU782602551A patent/SU682132A3/en active
- 1978-04-17 SU SU782602552A patent/SU680648A3/en active
-
1983
- 1983-05-19 HK HK167/83A patent/HK16783A/en unknown
-
1984
- 1984-12-30 MY MY93/84A patent/MY8400093A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK16783A (en) | 1983-05-27 |
| CY1179A (en) | 1983-06-10 |
| GB1565055A (en) | 1980-04-16 |
| IE44084L (en) | 1977-05-26 |
| FR2332754A2 (en) | 1977-06-24 |
| DK142987B (en) | 1981-03-09 |
| MY8400093A (en) | 1984-12-31 |
| ATA874476A (en) | 1979-03-15 |
| AT352728B (en) | 1979-10-10 |
| CS205049B2 (en) | 1981-04-30 |
| CH609054A5 (en) | 1979-02-15 |
| CS205050B2 (en) | 1981-04-30 |
| SU682132A3 (en) | 1979-08-25 |
| SE426826B (en) | 1983-02-14 |
| FR2332754B2 (en) | 1978-12-22 |
| ZA777068B (en) | 1978-07-26 |
| AU1999576A (en) | 1978-06-01 |
| DE2653147C2 (en) | 1991-09-19 |
| JPS5265277A (en) | 1977-05-30 |
| DK142987C (en) | 1981-09-21 |
| SU679136A3 (en) | 1979-08-05 |
| SU680648A3 (en) | 1979-08-15 |
| SE7613193L (en) | 1977-05-27 |
| AR214985A1 (en) | 1979-08-31 |
| JPS6156234B2 (en) | 1986-12-01 |
| DD129328A6 (en) | 1978-01-11 |
| BE848720R (en) | 1977-05-25 |
| DE2653147A1 (en) | 1977-06-08 |
| DK532176A (en) | 1977-05-27 |
| AU507722B2 (en) | 1980-02-28 |
| IE44084B1 (en) | 1981-08-12 |
| NZ182716A (en) | 1979-06-19 |
| CA1088940A (en) | 1980-11-04 |
| NL7613050A (en) | 1977-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES452766A1 (en) | 2-Tetrahydrofurfuryl-5-(methyl or phenyl)-9{62 -methyl-2{40 -oxy-6,7-benzomorphans and salts thereof | |
| GB1491510A (en) | 1-nitrophenylquinazoline-2,4(1h,3h)-diones | |
| ES413639A1 (en) | Dopamine derivatives | |
| ES453582A2 (en) | Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof | |
| ES8504738A1 (en) | Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions. | |
| ES461631A1 (en) | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1- (BENZAZOLYLALKYL) PIPERIDINE. | |
| ES479991A1 (en) | A PROCEDURE FOR THE PREPARATION OF PHTHALAZINES. | |
| SE7501365L (en) | ||
| GB861561A (en) | N-substituted piperidines | |
| GB830709A (en) | Improvements in or relating to piperidine-carboxamide derivatives | |
| ES441591A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW PYRIDOBENZODIA- ZEPINONES. | |
| ES426303A1 (en) | Procedure for the obtaining of oxazolidine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES438138A1 (en) | A PROCEDURE FOR PREPARING TIOXANTION-2-CARBOXYLIC ACIDS. | |
| ES463783A1 (en) | Cis-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindines and pharmaceutical compositions containing them | |
| ES8207141A1 (en) | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF HYDROXIFENIL-TETRAHIDROPIRIDINA. | |
| ES464533A2 (en) | Process for the manufacture of 5-methyl isoxazole-4-carboxylic acid anilide derivatives | |
| ES475157A1 (en) | New derivative of benzensulfonamido and benzencarboxyamido * method of its production and drug composition containing these | |
| IE41916L (en) | Amino-substituted tetracyclic compounds | |
| IE43917L (en) | 4-(9, 10-DIHYDRO-4H-BENZO [4,5] CYCLOHEPTA [1,2-b]¹THIOPHEN-4-YLIDENE) PIPERIDINES | |
| IE43641L (en) | Aroyl-phenylnaphthalenes | |
| ES8506011A1 (en) | Derivatives of tetrahydrobenzothiazole and herbicidal compositions containing the same as an active ingredient | |
| ES270558A1 (en) | Procedure for the preparation of new derivatives of the alquilbenzoico acid (Machine-translation by Google Translate, not legally binding) | |
| GB1033261A (en) | New derivatives of 2,5-bis-(amino-oxymethyl)-3,6-diketo piperazine and a method for their preparation | |
| GB873316A (en) | Optically active 3-mercapto-phenthiazine derivatives | |
| ES402551A1 (en) | A procedure for the preparation of piperazine derivatives. (Machine-translation by Google Translate, not legally binding) |