ES453869A1 - Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica. - Google Patents
Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica.Info
- Publication number
- ES453869A1 ES453869A1 ES453869A ES453869A ES453869A1 ES 453869 A1 ES453869 A1 ES 453869A1 ES 453869 A ES453869 A ES 453869A ES 453869 A ES453869 A ES 453869A ES 453869 A1 ES453869 A1 ES 453869A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- heparing
- pharmaceutical compositions
- compositions containing
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960003133 ergot alkaloid Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical group 0.000 abstract 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011343 solid material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Electronic Switches (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedimiento para la producción de una preparación terapéutica antitrombótica, que contiene compuestos de fórmula I **(Fórmula)** en donde R es hidrógeno o alquilo de 1 a 4 átomos de carbono, R1 es metilo, etilo o isopropilo, R2 es isopropilo, butilo sec., isobutilo o bencilo, y X es hidrógeno o metoxi, o sales de los mismos, y heparina o sales de la misma, conjuntamente; caracterizado porque se tratan los compuestos de fórmula I o sus sales, con polivinilpirrolidona para obtener un material sólido, preferiblemente por disolución en agua y ulterior secado por congelación, y se mezcla este material con heparina o sus sales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2554533A DE2554533C3 (de) | 1975-12-04 | 1975-12-04 | Verwendung von Dihydroergotamin und Heparin |
| DE19762625403 DE2625403A1 (de) | 1976-06-05 | 1976-06-05 | Neue therapeutische mischung und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453869A1 true ES453869A1 (es) | 1978-01-16 |
Family
ID=25769698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453869A Expired ES453869A1 (es) | 1975-12-04 | 1976-12-02 | Procedimiento para la produccion de una preparacion terapeu-tica antitrombotica. |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5270031A (es) |
| AU (1) | AU512782B2 (es) |
| CS (1) | CS216164B2 (es) |
| ES (1) | ES453869A1 (es) |
| FR (1) | FR2333513A1 (es) |
| GB (1) | GB1557331A (es) |
| HK (1) | HK3083A (es) |
| IE (1) | IE44359B1 (es) |
| IL (1) | IL51043A (es) |
| IT (1) | IT7827782A0 (es) |
| MY (1) | MY8400064A (es) |
| NL (1) | NL172401C (es) |
| NZ (1) | NZ182790A (es) |
| PH (1) | PH12759A (es) |
| PT (1) | PT65919B (es) |
| SE (1) | SE441142B (es) |
| SG (1) | SG63482G (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809618A1 (de) * | 1978-03-06 | 1979-09-20 | Sandoz Ag | Neues therapeutisches praeparat und verfahren zu dessen herstellung |
| CH656533A5 (de) * | 1982-12-10 | 1986-07-15 | Sandoz Ag | Therapeutisches praeparat enthaltend hydrierte ergotalkaloide und niedermolekulares heparin. |
-
1976
- 1976-11-26 SE SE7613252A patent/SE441142B/xx not_active IP Right Cessation
- 1976-11-30 FR FR7636023A patent/FR2333513A1/fr active Granted
- 1976-11-30 GB GB49835/76A patent/GB1557331A/en not_active Expired
- 1976-11-30 NL NLAANVRAGE7613316,A patent/NL172401C/xx not_active IP Right Cessation
- 1976-12-02 CS CS767848A patent/CS216164B2/cs unknown
- 1976-12-02 IE IE2647/76A patent/IE44359B1/en not_active IP Right Cessation
- 1976-12-02 IL IL51043A patent/IL51043A/xx unknown
- 1976-12-02 NZ NZ182790A patent/NZ182790A/xx unknown
- 1976-12-02 ES ES453869A patent/ES453869A1/es not_active Expired
- 1976-12-02 PT PT65919A patent/PT65919B/pt unknown
- 1976-12-03 AU AU20249/76A patent/AU512782B2/en not_active Expired
- 1976-12-03 PH PH19195A patent/PH12759A/en unknown
- 1976-12-03 JP JP51144868A patent/JPS5270031A/ja active Pending
-
1978
- 1978-09-18 IT IT7827782A patent/IT7827782A0/it unknown
-
1982
- 1982-12-23 SG SG634/82A patent/SG63482G/en unknown
-
1983
- 1983-01-20 HK HK30/83A patent/HK3083A/xx unknown
-
1984
- 1984-12-30 MY MY64/84A patent/MY8400064A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE44359B1 (en) | 1981-11-04 |
| IL51043A (en) | 1980-02-29 |
| IL51043A0 (en) | 1977-02-28 |
| SE441142B (sv) | 1985-09-16 |
| PH12759A (en) | 1979-08-09 |
| PT65919B (fr) | 1978-07-05 |
| JPS5270031A (en) | 1977-06-10 |
| CS216164B2 (en) | 1982-10-29 |
| SG63482G (en) | 1983-09-09 |
| AU512782B2 (en) | 1980-10-30 |
| IE44359L (en) | 1977-06-04 |
| GB1557331A (en) | 1979-12-05 |
| IT7827782A0 (it) | 1978-09-18 |
| AU2024976A (en) | 1978-06-08 |
| SE7613252L (sv) | 1977-06-05 |
| NL7613316A (nl) | 1977-06-07 |
| NL172401C (nl) | 1983-09-01 |
| FR2333513B1 (es) | 1980-03-28 |
| NL172401B (nl) | 1983-04-05 |
| MY8400064A (en) | 1984-12-31 |
| HK3083A (en) | 1983-01-20 |
| PT65919A (fr) | 1977-01-01 |
| NZ182790A (en) | 1979-03-16 |
| FR2333513A1 (fr) | 1977-07-01 |
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