ES455025A1 - Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico. - Google Patents

Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico.

Info

Publication number: ES455025A1
Authority: ES; Spain
Prior art keywords: lower alkyl; semi; manufacture; penicillin antibiotics; aralkyl
Prior art date: 1976-01-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES455025A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Laboratories Ltd

Original Assignee

Glaxo Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-01-15

Filing date

1977-01-14

Publication date

1977-12-16

1977-01-14 Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd

1977-12-16 Publication of ES455025A1 publication Critical patent/ES455025A1/es

Status Expired legal-status Critical Current

Links

229930182555 Penicillin Natural products 0.000 title abstract 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title abstract 2
229940088710 antibiotic agent Drugs 0.000 title abstract 2
229940049954 penicillin Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 2
238000005917 acylation reaction Methods 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
239000012433 hydrogen halide Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES455025A 1976-01-15 1977-01-14 Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico. Expired ES455025A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT47642/76A IT1053312B (it)	1976-01-15	1976-01-15	Procedimento per la produzione di antibiotici di penicillina semisintetici

Publications (1)

Publication Number	Publication Date
ES455025A1 true ES455025A1 (es)	1977-12-16

Family

ID=11261615

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES455025A Expired ES455025A1 (es)	1976-01-15	1977-01-14	Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico.

Country Status (14)

Country	Link
JP (1)	JPS5287190A (da)
AU (1)	AU512149B2 (da)
BE (1)	BE850381A (da)
CH (1)	CH628635A5 (da)
DE (1)	DE2701407A1 (da)
DK (1)	DK143705C (da)
ES (1)	ES455025A1 (da)
FR (1)	FR2338278A1 (da)
GB (1)	GB1569426A (da)
IT (1)	IT1053312B (da)
NL (1)	NL7700395A (da)
SE (1)	SE7700392L (da)
YU (1)	YU9177A (da)
ZA (1)	ZA77194B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0953569A1 (en) *	1998-04-29	1999-11-03	Gist-Brocades B.V.	Preparation of beta-lactam antibiotics in the presence of urea or amide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB958478A (en) *	1962-03-13	1964-05-21	Beecham Res Lab	Production of penicillins
FR68F (da) *	1962-10-17
GB1104937A (en) *	1964-05-28	1968-03-06	Glaxo Lab Ltd	Improvements in or relating to the acylation of 7-aminocephalosporanic acid and derivatives thereof
US3351597A (en) *	1966-11-23	1967-11-07	Lilly Co Eli	Process for acylating 7-amino cephalosporanic acid
FR2220531A1 (en) *	1973-03-06	1974-10-04	Aries Robert	Synthesis of penicillins from 6-amino penicillanic acid - by acylation with acid chlorides using hexamethylphosphotriamide as solvent
GB1472746A (en) *	1973-07-05	1977-05-04	Glaxo Lab Ltd	Cephalosporin compounds
GB1459807A (en) *	1975-05-27	1976-12-31	Proter Spa	Process for the production of 7-d-a-amino-phenyl-acetamido-3- desacetoxy-cephalosporanic acid

1976
- 1976-01-15 IT IT47642/76A patent/IT1053312B/it active
1977
- 1977-01-13 CH CH43277A patent/CH628635A5/de not_active IP Right Cessation
- 1977-01-14 AU AU21339/77A patent/AU512149B2/en not_active Expired
- 1977-01-14 SE SE7700392A patent/SE7700392L/xx not_active Application Discontinuation
- 1977-01-14 DK DK13877A patent/DK143705C/da not_active IP Right Cessation
- 1977-01-14 DE DE19772701407 patent/DE2701407A1/de not_active Withdrawn
- 1977-01-14 JP JP251977A patent/JPS5287190A/ja active Granted
- 1977-01-14 BE BE174078A patent/BE850381A/xx not_active IP Right Cessation
- 1977-01-14 YU YU00091/77A patent/YU9177A/xx unknown
- 1977-01-14 NL NL7700395A patent/NL7700395A/xx not_active Application Discontinuation
- 1977-01-14 FR FR7701122A patent/FR2338278A1/fr active Granted
- 1977-01-14 ES ES455025A patent/ES455025A1/es not_active Expired
- 1977-01-14 ZA ZA770194A patent/ZA77194B/xx unknown
- 1977-01-14 GB GB1540/77A patent/GB1569426A/en not_active Expired

Also Published As

Publication number	Publication date
GB1569426A (en)	1980-06-18
YU9177A (en)	1982-06-30
CH628635A5 (en)	1982-03-15
IT1053312B (it)	1981-08-31
FR2338278B1 (da)	1981-06-12
SE7700392L (sv)	1977-07-16
AU2133977A (en)	1978-07-20
BE850381A (fr)	1977-07-14
DK13877A (da)	1977-07-16
AU512149B2 (en)	1980-09-25
DK143705B (da)	1981-09-28
JPS6135995B2 (da)	1986-08-15
ZA77194B (en)	1977-11-30
NL7700395A (nl)	1977-07-19
JPS5287190A (en)	1977-07-20
DE2701407A1 (de)	1977-07-21
FR2338278A1 (fr)	1977-08-12
DK143705C (da)	1982-03-08

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Legal Events

Date	Code	Title	Description
1999-01-01	FD1A	Patent lapsed	Effective date: 19981103