ES455805A1 - A PROCEDURE FOR PREPARING OLECENDOMIN DERIVATIVES. - Google Patents
A PROCEDURE FOR PREPARING OLECENDOMIN DERIVATIVES.Info
- Publication number
- ES455805A1 ES455805A1 ES455805A ES455805A ES455805A1 ES 455805 A1 ES455805 A1 ES 455805A1 ES 455805 A ES455805 A ES 455805A ES 455805 A ES455805 A ES 455805A ES 455805 A1 ES455805 A1 ES 455805A1
- Authority
- ES
- Spain
- Prior art keywords
- replaced
- positions
- hydroxyl groups
- olecendomin
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La oleandomicina, su producción en caldos de fermentación y su uso como agente antibacteriano. El compuesto de producción natural se sabe que tiene la estructura: **(fórmula)** El esquema numérico convencionalmente aceptado se ilustra en una variedad de posiciones. Se conocen varias modificaciones sintéticas de este compuesto, particularmente aquellas en las cuales de uno a tres de los grupos hidroxilo libres encontrados en las posiciones 2'', 4'''' y 11 son esterificados como ésteres acetílicos. Los ésteres mencionados precedentemente es reemplazado por otro alcanoílo, preferiblemente no ramificado, con dos a seis átomos de carbono o mitad trifluoroacetilo. También son conocidas las oleandomicinas semisintéticas en las cuales uno o varios hidrógenos de los grupos hidroxilo mencionados precedentemente son reemplazados con un tri(alquilo inferior)sililo y preferiblemente con un grupo trimetilsililo.Oleandomycin, its production in fermentation broths and its use as an antibacterial agent. The naturally occurring compound is known to have the structure: **(formula)** The conventionally accepted numerical scheme is illustrated in a variety of positions. Various synthetic modifications of this compound are known, particularly those in which one to three of the free hydroxyl groups found at the 2", 4"" and 11 positions are esterified as acetyl esters. The aforementioned esters are replaced by another, preferably unbranched, alkanoyl with two to six carbon atoms or trifluoroacetyl moiety. Semisynthetic oleandomycins are also known in which one or more hydrogens of the aforementioned hydroxyl groups are replaced with a tri(lower alkyl)silyl and preferably with a trimethylsilyl group.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66346776A | 1976-03-03 | 1976-03-03 | |
| US70346476A | 1976-07-08 | 1976-07-08 | |
| US05/709,703 US4069379A (en) | 1976-07-08 | 1976-07-29 | Semi-synthetic oleandomycins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455805A1 true ES455805A1 (en) | 1978-04-01 |
Family
ID=27418084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES455805A Expired ES455805A1 (en) | 1976-03-03 | 1977-02-10 | A PROCEDURE FOR PREPARING OLECENDOMIN DERIVATIVES. |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS52106880A (en) |
| AR (1) | AR212524A1 (en) |
| AT (1) | AT347586B (en) |
| BG (2) | BG27913A3 (en) |
| CA (1) | CA1069503A (en) |
| DD (1) | DD129789A5 (en) |
| DE (2) | DE2660089C2 (en) |
| DK (1) | DK146778C (en) |
| ES (1) | ES455805A1 (en) |
| FI (1) | FI770440A7 (en) |
| FR (1) | FR2342989A1 (en) |
| GB (1) | GB1567390A (en) |
| IE (1) | IE44509B1 (en) |
| IL (1) | IL51361A (en) |
| LU (1) | LU76764A1 (en) |
| NL (1) | NL170151C (en) |
| NZ (1) | NZ183235A (en) |
| PH (1) | PH13171A (en) |
| PT (1) | PT66157B (en) |
| RO (2) | RO72560A (en) |
| SE (2) | SE436283B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166901A (en) * | 1978-01-03 | 1979-09-04 | Pfizer Inc. | 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters |
| US4180654A (en) * | 1978-01-03 | 1979-12-25 | Pfizer Inc. | 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate |
-
1976
- 1976-11-23 IE IE2578/76A patent/IE44509B1/en unknown
- 1976-12-02 DE DE2660089A patent/DE2660089C2/en not_active Expired
- 1976-12-02 DE DE2654627A patent/DE2654627C3/en not_active Expired
-
1977
- 1977-01-25 SE SE7700786A patent/SE436283B/en unknown
- 1977-01-31 IL IL51361A patent/IL51361A/en unknown
- 1977-02-01 AT AT62777A patent/AT347586B/en not_active IP Right Cessation
- 1977-02-02 NZ NZ183235A patent/NZ183235A/en unknown
- 1977-02-02 PH PH19411A patent/PH13171A/en unknown
- 1977-02-04 PT PT66157A patent/PT66157B/en unknown
- 1977-02-09 CA CA271,457A patent/CA1069503A/en not_active Expired
- 1977-02-09 FR FR7703604A patent/FR2342989A1/en active Granted
- 1977-02-10 JP JP1403577A patent/JPS52106880A/en active Granted
- 1977-02-10 FI FI770440A patent/FI770440A7/fi not_active Application Discontinuation
- 1977-02-10 ES ES455805A patent/ES455805A1/en not_active Expired
- 1977-02-10 DK DK57177A patent/DK146778C/en not_active IP Right Cessation
- 1977-02-10 NL NLAANVRAGE7701401,A patent/NL170151C/en not_active IP Right Cessation
- 1977-02-11 GB GB5755/77A patent/GB1567390A/en not_active Expired
- 1977-02-11 AR AR266519A patent/AR212524A1/en active
- 1977-02-11 LU LU76764A patent/LU76764A1/xx unknown
- 1977-02-23 RO RO7789496A patent/RO72560A/en unknown
- 1977-02-23 RO RO7797127A patent/RO76882A/en unknown
- 1977-02-25 BG BG035526A patent/BG27913A3/en unknown
- 1977-02-25 BG BG036454A patent/BG27914A4/en unknown
- 1977-02-28 DD DD7700197598A patent/DD129789A5/en unknown
-
1980
- 1980-07-01 SE SE8004873A patent/SE436284B/en unknown
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