IE44509L - Semi-synthetic oleandomycins - Google Patents
Semi-synthetic oleandomycinsInfo
- Publication number
- IE44509L IE44509L IE762578A IE257876A IE44509L IE 44509 L IE44509 L IE 44509L IE 762578 A IE762578 A IE 762578A IE 257876 A IE257876 A IE 257876A IE 44509 L IE44509 L IE 44509L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- semi
- oleandomycins
- methylene
- synthetic
- Prior art date
Links
- 235000019367 oleandomycin Nutrition 0.000 title abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical class O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Disclosed herein is a novel series of semi-synthetic oleandomycins having an exocyclic methylene or a cyclopropyl group at the C8 position. Processes for preparing the methylene compounds from the natural oleandomycins and the cyclopropyl compounds from the methylene compounds are also disclosed. The above oleandomycin compounds are effective in inhibiting the growth of microorganism, especially Gram-positive microorganism.
[CA1069503A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66346776A | 1976-03-03 | 1976-03-03 | |
| US70346476A | 1976-07-08 | 1976-07-08 | |
| US05/709,703 US4069379A (en) | 1976-07-08 | 1976-07-29 | Semi-synthetic oleandomycins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44509L true IE44509L (en) | 1977-09-03 |
| IE44509B1 IE44509B1 (en) | 1981-12-30 |
Family
ID=27418084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2578/76A IE44509B1 (en) | 1976-03-03 | 1976-11-23 | Semi-synthetic oleandomycins |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS52106880A (en) |
| AR (1) | AR212524A1 (en) |
| AT (1) | AT347586B (en) |
| BG (2) | BG27913A3 (en) |
| CA (1) | CA1069503A (en) |
| DD (1) | DD129789A5 (en) |
| DE (2) | DE2660089C2 (en) |
| DK (1) | DK146778C (en) |
| ES (1) | ES455805A1 (en) |
| FI (1) | FI770440A7 (en) |
| FR (1) | FR2342989A1 (en) |
| GB (1) | GB1567390A (en) |
| IE (1) | IE44509B1 (en) |
| IL (1) | IL51361A (en) |
| LU (1) | LU76764A1 (en) |
| NL (1) | NL170151C (en) |
| NZ (1) | NZ183235A (en) |
| PH (1) | PH13171A (en) |
| PT (1) | PT66157B (en) |
| RO (2) | RO72560A (en) |
| SE (2) | SE436283B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166901A (en) * | 1978-01-03 | 1979-09-04 | Pfizer Inc. | 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters |
| US4180654A (en) * | 1978-01-03 | 1979-12-25 | Pfizer Inc. | 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate |
-
1976
- 1976-11-23 IE IE2578/76A patent/IE44509B1/en unknown
- 1976-12-02 DE DE2660089A patent/DE2660089C2/en not_active Expired
- 1976-12-02 DE DE2654627A patent/DE2654627C3/en not_active Expired
-
1977
- 1977-01-25 SE SE7700786A patent/SE436283B/en unknown
- 1977-01-31 IL IL51361A patent/IL51361A/en unknown
- 1977-02-01 AT AT62777A patent/AT347586B/en not_active IP Right Cessation
- 1977-02-02 NZ NZ183235A patent/NZ183235A/en unknown
- 1977-02-02 PH PH19411A patent/PH13171A/en unknown
- 1977-02-04 PT PT66157A patent/PT66157B/en unknown
- 1977-02-09 CA CA271,457A patent/CA1069503A/en not_active Expired
- 1977-02-09 FR FR7703604A patent/FR2342989A1/en active Granted
- 1977-02-10 JP JP1403577A patent/JPS52106880A/en active Granted
- 1977-02-10 FI FI770440A patent/FI770440A7/fi not_active Application Discontinuation
- 1977-02-10 ES ES455805A patent/ES455805A1/en not_active Expired
- 1977-02-10 DK DK57177A patent/DK146778C/en not_active IP Right Cessation
- 1977-02-10 NL NLAANVRAGE7701401,A patent/NL170151C/en not_active IP Right Cessation
- 1977-02-11 GB GB5755/77A patent/GB1567390A/en not_active Expired
- 1977-02-11 AR AR266519A patent/AR212524A1/en active
- 1977-02-11 LU LU76764A patent/LU76764A1/xx unknown
- 1977-02-23 RO RO7789496A patent/RO72560A/en unknown
- 1977-02-23 RO RO7797127A patent/RO76882A/en unknown
- 1977-02-25 BG BG035526A patent/BG27913A3/en unknown
- 1977-02-25 BG BG036454A patent/BG27914A4/en unknown
- 1977-02-28 DD DD7700197598A patent/DD129789A5/en unknown
-
1980
- 1980-07-01 SE SE8004873A patent/SE436284B/en unknown
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