ES461101A2 - Heterocyclic compound - Google Patents
Heterocyclic compoundInfo
- Publication number
- ES461101A2 ES461101A2 ES461101A ES461101A ES461101A2 ES 461101 A2 ES461101 A2 ES 461101A2 ES 461101 A ES461101 A ES 461101A ES 461101 A ES461101 A ES 461101A ES 461101 A2 ES461101 A2 ES 461101A2
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- hydroxy
- ring
- het
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Mejoras introducidas en el objeto de la patente principal nº 434.542 por: procedimiento para preparar compuestos antagonistas de receptores H-2 de histamina de fórmula **fórmula ** en la que Het es una anillo piridina, tiazol, isotiazol, oxazol, isoxazol, tiadiazol, pirimidina, pirazina o piridazina, cuyo anillo está opcionalmente sustituido por alquilo inferior, alcoxi inferior, hidroxi, halógeno o amino Y es hidrógeno, hidroxi o alquilo inferior, y X es azufre, VHNO2 o NY'' en donde Y'' es hidrógeno, hidroxi, alquilo inferior, ciano o CONH2; W es NH o , cuando NY y X son ambos NH, azufre, q es un entero de 2 a 12 ; n es 2 o 3 y m es 0, 1 o 2, de modo que la suma de m y n sea 3 4 o, excepto cuando X es NH, NOH, NCONH2 o N (alquilo inferior) y Het''es imidazol, triazol o pirazol, dicha suma de m y n es 2; Z es azufre o un grupo metileno, Het'' es un anillo heterociclico nitrogenado de 5 o 6 miembros, tal como imidazol, piridina, tiazol, isotiazol, oxazol, isoxazol, pirazol, triazol, triadiazol,pirimidina , pirazina o piridazina, cuyo anillo está opcionalmente sustituido por alquilo inferior, alcoxi inferior, hidroxi, halógeno o amino y sus sales de adición de ácido farmacéuticamente aceptables.Improvements introduced in the object of the main patent No. 434,542 by: process for preparing histamine H-2 receptor antagonist compounds of formula **formula ** in which Het is a pyridine, thiazole, isothiazole, oxazole, isoxazole, thiadiazole ring , pyrimidine, pyrazine or pyridazine, which ring is optionally substituted by lower alkyl, lower alkoxy, hydroxy, halogen or amino Y is hydrogen, hydroxy or lower alkyl, and X is sulfur, VHNO2 or NY'' where Y'' is hydrogen , hydroxy, lower alkyl, cyano, or CONH2; W is NH or , when NY and X are both NH, sulfur, q is an integer from 2 to 12 ; n is 2 or 3 and m is 0, 1 or 2 such that the sum of m and n is 3 4 o, except when X is NH, NOH, NCONH2 or N(lower alkyl) and Het'' is imidazole, triazole or pyrazole , said sum of m and n is 2; Z is sulfur or a methylene group, Het'' is a 5- or 6-membered nitrogen heterocyclic ring, such as imidazole, pyridine, thiazole, isothiazole, oxazole, isoxazole, pyrazole, triazole, triadiazole, pyrimidine, pyrazine or pyridazine, which ring it is optionally substituted by lower alkyl, lower alkoxy, hydroxy, halogen or amino and pharmaceutically acceptable acid addition salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3139376 | 1976-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461101A2 true ES461101A2 (en) | 1978-12-01 |
Family
ID=10322438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461101A Expired ES461101A2 (en) | 1976-07-28 | 1977-07-28 | Heterocyclic compound |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5315371A (en) |
| AU (1) | AU2734777A (en) |
| BE (1) | BE857219R (en) |
| DE (1) | DE2733952A1 (en) |
| DK (1) | DK331977A (en) |
| ES (1) | ES461101A2 (en) |
| FI (1) | FI772294A7 (en) |
| FR (1) | FR2359841A1 (en) |
| IL (1) | IL52545A0 (en) |
| LU (1) | LU77865A1 (en) |
| NL (1) | NL7708379A (en) |
| NO (1) | NO772669L (en) |
| PL (1) | PL199909A1 (en) |
| ZA (1) | ZA774221B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309435A (en) | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| FR2446829A1 (en) | 1978-11-16 | 1980-08-14 | Glaxo Group Ltd | POLYMETHYLENE DERIVATIVES DISUBSTITUTED IN ALPHA, OMEGA, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| JPS57102852A (en) * | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
| US5352831A (en) * | 1987-09-02 | 1994-10-04 | Ciba-Geigy Corporation | Oligomeric cyanoguanidines |
| ATE70261T1 (en) * | 1987-09-02 | 1991-12-15 | Ciba Geigy Ag | OLIGOMERIC CYANOGUANIDINES. |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR735087A (en) * | 1930-09-01 | 1932-11-03 | Anticoman Ges M B H | Process for making polymethylene-biguanidine salts which dissolve easily in water and in gastric juice |
| GB1493931A (en) * | 1974-02-07 | 1977-11-30 | Smith Kline French Lab | Guanidines isothioureas and thioureas |
-
1977
- 1977-07-14 ZA ZA00774221A patent/ZA774221B/en unknown
- 1977-07-18 IL IL52545A patent/IL52545A0/en unknown
- 1977-07-22 DK DK331977A patent/DK331977A/en not_active Application Discontinuation
- 1977-07-26 AU AU27347/77A patent/AU2734777A/en active Pending
- 1977-07-27 BE BE179688A patent/BE857219R/en active
- 1977-07-27 FR FR7723081A patent/FR2359841A1/en active Pending
- 1977-07-27 NO NO772669A patent/NO772669L/en unknown
- 1977-07-27 FI FI772294A patent/FI772294A7/fi not_active Application Discontinuation
- 1977-07-27 DE DE19772733952 patent/DE2733952A1/en not_active Withdrawn
- 1977-07-28 LU LU77865A patent/LU77865A1/xx unknown
- 1977-07-28 JP JP9132577A patent/JPS5315371A/en active Pending
- 1977-07-28 ES ES461101A patent/ES461101A2/en not_active Expired
- 1977-07-28 NL NL7708379A patent/NL7708379A/en not_active Application Discontinuation
- 1977-07-28 PL PL19990977A patent/PL199909A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL52545A0 (en) | 1977-10-31 |
| JPS5315371A (en) | 1978-02-13 |
| FR2359841A1 (en) | 1978-02-24 |
| LU77865A1 (en) | 1977-10-24 |
| NL7708379A (en) | 1978-01-31 |
| NO772669L (en) | 1978-01-31 |
| FI772294A7 (en) | 1978-01-29 |
| DE2733952A1 (en) | 1978-02-02 |
| DK331977A (en) | 1978-01-29 |
| BE857219R (en) | 1978-01-27 |
| AU2734777A (en) | 1979-02-01 |
| PL199909A1 (en) | 1978-11-20 |
| ZA774221B (en) | 1978-06-28 |
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