ES461101A2 - Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina. - Google Patents

Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina.

Info

Publication number
ES461101A2
ES461101A2 ES461101A ES461101A ES461101A2 ES 461101 A2 ES461101 A2 ES 461101A2 ES 461101 A ES461101 A ES 461101A ES 461101 A ES461101 A ES 461101A ES 461101 A2 ES461101 A2 ES 461101A2
Authority
ES
Spain
Prior art keywords
lower alkyl
hydroxy
ring
het
sulfur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461101A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline & French Laboratories Ltd
Original Assignee
Smith Kline & French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Laboratories Ltd filed Critical Smith Kline & French Laboratories Ltd
Publication of ES461101A2 publication Critical patent/ES461101A2/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mejoras introducidas en el objeto de la patente principal nº 434.542 por: procedimiento para preparar compuestos antagonistas de receptores H-2 de histamina de fórmula **fórmula ** en la que Het es una anillo piridina, tiazol, isotiazol, oxazol, isoxazol, tiadiazol, pirimidina, pirazina o piridazina, cuyo anillo está opcionalmente sustituido por alquilo inferior, alcoxi inferior, hidroxi, halógeno o amino Y es hidrógeno, hidroxi o alquilo inferior, y X es azufre, VHNO2 o NY'' en donde Y'' es hidrógeno, hidroxi, alquilo inferior, ciano o CONH2; W es NH o , cuando NY y X son ambos NH, azufre, q es un entero de 2 a 12 ; n es 2 o 3 y m es 0, 1 o 2, de modo que la suma de m y n sea 3 4 o, excepto cuando X es NH, NOH, NCONH2 o N (alquilo inferior) y Het''es imidazol, triazol o pirazol, dicha suma de m y n es 2; Z es azufre o un grupo metileno, Het'' es un anillo heterociclico nitrogenado de 5 o 6 miembros, tal como imidazol, piridina, tiazol, isotiazol, oxazol, isoxazol, pirazol, triazol, triadiazol,pirimidina , pirazina o piridazina, cuyo anillo está opcionalmente sustituido por alquilo inferior, alcoxi inferior, hidroxi, halógeno o amino y sus sales de adición de ácido farmacéuticamente aceptables.
ES461101A 1976-07-28 1977-07-28 Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina. Expired ES461101A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3139376 1976-07-28

Publications (1)

Publication Number Publication Date
ES461101A2 true ES461101A2 (es) 1978-12-01

Family

ID=10322438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES461101A Expired ES461101A2 (es) 1976-07-28 1977-07-28 Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina.

Country Status (14)

Country Link
JP (1) JPS5315371A (es)
AU (1) AU2734777A (es)
BE (1) BE857219R (es)
DE (1) DE2733952A1 (es)
DK (1) DK331977A (es)
ES (1) ES461101A2 (es)
FI (1) FI772294A7 (es)
FR (1) FR2359841A1 (es)
IL (1) IL52545A0 (es)
LU (1) LU77865A1 (es)
NL (1) NL7708379A (es)
NO (1) NO772669L (es)
PL (1) PL199909A1 (es)
ZA (1) ZA774221B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
FR2446829A1 (fr) 1978-11-16 1980-08-14 Glaxo Group Ltd Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
US5352831A (en) * 1987-09-02 1994-10-04 Ciba-Geigy Corporation Oligomeric cyanoguanidines
ATE70261T1 (de) * 1987-09-02 1991-12-15 Ciba Geigy Ag Oligomere cyanoguanidine.
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR735087A (fr) * 1930-09-01 1932-11-03 Anticoman Ges M B H Procédé pour fabriquer des sels de polyméthylène-biguanidine se dissolvant facilement dans l'eau et dans le suc gastrique
GB1493931A (en) * 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas

Also Published As

Publication number Publication date
IL52545A0 (en) 1977-10-31
JPS5315371A (en) 1978-02-13
FR2359841A1 (fr) 1978-02-24
LU77865A1 (es) 1977-10-24
NL7708379A (nl) 1978-01-31
NO772669L (no) 1978-01-31
FI772294A7 (es) 1978-01-29
DE2733952A1 (de) 1978-02-02
DK331977A (da) 1978-01-29
BE857219R (fr) 1978-01-27
AU2734777A (en) 1979-02-01
PL199909A1 (pl) 1978-11-20
ZA774221B (en) 1978-06-28

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