ES461631A1 - Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina.

Info

Publication number
ES461631A1
ES461631A1 ES461631A ES461631A ES461631A1 ES 461631 A1 ES461631 A1 ES 461631A1 ES 461631 A ES461631 A ES 461631A ES 461631 A ES461631 A ES 461631A ES 461631 A1 ES461631 A1 ES 461631A1
Authority
ES
Spain
Prior art keywords
benzazolylalkyl
piperidine
procedure
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461631A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/687,139 external-priority patent/US4066772A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES461631A1 publication Critical patent/ES461631A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de 1- (benzazolilalquil) piperidina de fórmula: **(Fórmula)** y sus sales de adición de ácido farmacéuticamente aceptables donde R1 y R2 están seleccionados cada uno de ellos independientemente entre el grupo formado por hidrógeno, halógeno alquilo inferior y trifluormetilo; R3 es un miembro seleccionado entre el grupo formado por hidrógeno y metilo; m y n son cada uno de ellos un número entero de 1 a 2 inclusive.
ES461631A 1975-07-21 1977-08-16 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina. Expired ES461631A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59779375A 1975-07-21 1975-07-21
US05/687,139 US4066772A (en) 1975-07-21 1976-05-17 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
KR7601697A KR810000334B1 (ko) 1975-07-21 1976-07-12 1-(벤즈 아조릴알킬) 피페리딘 유도체의 제조방법

Publications (1)

Publication Number Publication Date
ES461631A1 true ES461631A1 (es) 1978-12-01

Family

ID=27348142

Family Applications (3)

Application Number Title Priority Date Filing Date
ES449740A Expired ES449740A1 (es) 1975-07-21 1976-07-09 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil) piperidina.
ES461631A Expired ES461631A1 (es) 1975-07-21 1977-08-16 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina.
ES461630A Expired ES461630A1 (es) 1975-07-21 1977-08-16 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES449740A Expired ES449740A1 (es) 1975-07-21 1976-07-09 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil) piperidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES461630A Expired ES461630A1 (es) 1975-07-21 1977-08-16 Un procedimiento para la preparacion de nuevos derivados de 1-(benzazolilalquil)piperidina.

Country Status (25)

Country Link
JP (1) JPS5217475A (es)
AT (1) AT364358B (es)
AU (1) AU511027B2 (es)
BG (1) BG26526A3 (es)
CA (1) CA1085852A (es)
CH (1) CH623820A5 (es)
CS (1) CS202550B2 (es)
DE (1) DE2632870A1 (es)
DK (1) DK154950C (es)
ES (3) ES449740A1 (es)
FI (1) FI62667C (es)
GB (1) GB1542514A (es)
HK (1) HK14180A (es)
IE (1) IE43496B1 (es)
IT (1) IT1062614B (es)
KE (1) KE3215A (es)
LU (1) LU75354A1 (es)
MY (1) MY8100017A (es)
NL (1) NL187442C (es)
NZ (1) NZ181256A (es)
PH (1) PH13710A (es)
PT (1) PT65387B (es)
RO (1) RO70566A (es)
SE (2) SE426490B (es)
YU (1) YU39969B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
JPS6248684A (ja) * 1985-08-26 1987-03-03 Sumitomo Chem Co Ltd 新規なヨ−ドブチロフエノン誘導体およびその製造法
JPS62251313A (ja) * 1986-04-25 1987-11-02 信越ポリマー株式会社 結束装置
US6355659B1 (en) 1994-07-29 2002-03-12 Laboratorios Del Dr. Esteve, S.A. 4-(4-Chlorophenyl)-1236-tetrahydro-1(1H-124-triazol-1-yl)butty)pyrideine and salts thereof; pharmaceutical compositions and method of treating psychoses utilizing same
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
RU2192848C1 (ru) * 2001-10-30 2002-11-20 Закрытое акционерное общество "ВЕРОФАРМ" Противорвотное средство
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
RU2268047C2 (ru) * 2003-12-15 2006-01-20 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Лекарственная форма, обладающая противорвотным действием, и способ ее изготовления
AU2004298448B2 (en) 2003-12-18 2010-09-09 Janssen Pharmaceutica N.V. Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
CA2654583C (en) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
EP1997805A1 (en) * 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans
AU2008281849B2 (en) 2007-07-27 2013-11-28 Janssen Pharmaceutica Nv Pyrrolopyrimidines
WO2009027820A2 (en) 2007-08-31 2009-03-05 Purdue Pharma L.P. Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
CN108697700B (zh) * 2016-02-04 2021-08-17 辛多美制药有限公司 氘代多潘立酮组合物和用于治疗病症的方法
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (es) * 1962-06-13
BE633914A (es) * 1962-06-22
US3629267A (en) * 1968-10-28 1971-12-21 Smith Kline French Lab Benzoheterocyclicalkyl derivatives of 4-(2-keto -1-benzimidazolinyl)-piperidine 4-(2-keto - 1 - benzimidazolinyl) -1 2 3 6 tetrahydropyridine 1 - phenyl - 1 3 8-triazaspiro(4 5)decan - 4 - one and 2 4 9-triazaspiro(5 5)undecan-1 3 5-trione
AU4698672A (en) * 1972-09-22 1972-11-09 Ciba-Geigy Ag Azacycloaliphatic compounds, process for their manufacture and compositions containing them
FR2218100A1 (en) * 1973-02-20 1974-09-13 Janssen Pharmaceutica Nv Neuroleptic tricyclic derivs. - of benzimidazolinones and triazaspiro-4,5-decan-4-ones
US3989707A (en) * 1974-06-21 1976-11-02 Janssen Pharmaceutica N.V. Benzimidazolinone derivatives

Also Published As

Publication number Publication date
IE43496B1 (en) 1981-03-11
NL187442B (nl) 1991-05-01
AT364358B (de) 1981-10-12
KE3215A (en) 1982-07-09
SE435621B (sv) 1984-10-08
BG26526A3 (bg) 1979-04-12
HK14180A (en) 1980-03-28
LU75354A1 (es) 1977-02-28
DK327576A (da) 1977-01-22
FI62667B (fi) 1982-10-29
GB1542514A (en) 1979-03-21
DK154950C (da) 1989-05-29
PT65387B (en) 1978-06-09
ES461630A1 (es) 1978-06-16
JPS6131109B2 (es) 1986-07-17
IE43496L (en) 1977-01-21
DE2632870C2 (es) 1989-02-16
PT65387A (en) 1976-08-01
PH13710A (en) 1980-09-09
FI762086A7 (es) 1977-01-22
NL7608023A (nl) 1977-01-25
NZ181256A (en) 1978-04-28
YU39969B (en) 1985-06-30
DK154950B (da) 1989-01-09
SE7608265L (sv) 1977-01-22
MY8100017A (en) 1981-12-31
AU1596476A (en) 1978-01-19
SE8008713L (sv) 1980-12-11
SE426490B (sv) 1983-01-24
ATA534776A (de) 1981-03-15
FI62667C (fi) 1983-02-10
YU179476A (en) 1983-01-21
DE2632870A1 (de) 1977-02-10
NL187442C (nl) 1991-10-01
CH623820A5 (en) 1981-06-30
CS202550B2 (en) 1981-01-30
RO70566A (ro) 1982-10-11
IT1062614B (it) 1984-10-20
AU511027B2 (en) 1980-07-24
JPS5217475A (en) 1977-02-09
CA1085852A (en) 1980-09-16
ES449740A1 (es) 1978-02-16

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