ES465217A1 - Un procedimiento para la preparacion de un nucleosido piri- midinico. - Google Patents

Un procedimiento para la preparacion de un nucleosido piri- midinico.

Info

Publication number
ES465217A1
ES465217A1 ES465217A ES465217A ES465217A1 ES 465217 A1 ES465217 A1 ES 465217A1 ES 465217 A ES465217 A ES 465217A ES 465217 A ES465217 A ES 465217A ES 465217 A1 ES465217 A1 ES 465217A1
Authority
ES
Spain
Prior art keywords
deoxy
fluorocytidine
fluorouridine
pharmaceutically acceptable
fluoropyrimidine nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465217A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES465217A1 publication Critical patent/ES465217A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la preparación de un nucleósido pirimidínico elegido del grupo constituido por 5¿-deoxi-5-fluorocitidina, 5¿-deoxi-5-fluorouridina y sus sales de adición de ácido aceptables en farmacia que se caracteriza porque se separa mediante hidrólisis el grupo 2¿,3¿-O-protector de la 5¿-deoxi-5-fluorocitidina o la 5¿-deoxi-5-fluorouridina 2¿,3¿-cetalizada, y porque, si se desea, se hace reaccionar la 5¿-deoxi-5-fluorocitidina o ¿uridina resultante con un ácido aceptable en farmacia.
ES465217A 1976-12-20 1977-12-19 Un procedimiento para la preparacion de un nucleosido piri- midinico. Expired ES465217A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/752,510 US4071680A (en) 1976-12-20 1976-12-20 5'-Deoxy-5-fluoropyrimidine nucleosides

Publications (1)

Publication Number Publication Date
ES465217A1 true ES465217A1 (es) 1978-12-01

Family

ID=25026612

Family Applications (2)

Application Number Title Priority Date Filing Date
ES465217A Expired ES465217A1 (es) 1976-12-20 1977-12-19 Un procedimiento para la preparacion de un nucleosido piri- midinico.
ES471584A Expired ES471584A1 (es) 1976-12-20 1978-07-10 Un procedimiento para la preparacion de un nucleosido piri- midinico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES471584A Expired ES471584A1 (es) 1976-12-20 1978-07-10 Un procedimiento para la preparacion de un nucleosido piri- midinico

Country Status (30)

Country Link
US (1) US4071680A (es)
JP (2) JPS5834479B2 (es)
AR (2) AR220692A1 (es)
AT (1) AT355733B (es)
AU (1) AU515446B2 (es)
BE (1) BE861984A (es)
CA (1) CA1085390A (es)
DE (1) DE2756653C2 (es)
DK (2) DK147858C (es)
ES (2) ES465217A1 (es)
FI (1) FI63946C (es)
FR (1) FR2374334A1 (es)
GB (1) GB1589688A (es)
GR (1) GR70039B (es)
HK (1) HK78284A (es)
HU (1) HU177104B (es)
IE (1) IE46107B1 (es)
IL (2) IL53589A (es)
IT (1) IT1089318B (es)
LU (1) LU78717A1 (es)
MC (1) MC1174A1 (es)
MY (1) MY8500246A (es)
NL (1) NL178878C (es)
NO (1) NO145307C (es)
NZ (1) NZ185965A (es)
PH (1) PH12784A (es)
PT (1) PT67429B (es)
SE (1) SE440361B (es)
YU (2) YU40688B (es)
ZA (1) ZA777238B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU724533A1 (ru) * 1977-08-02 1980-03-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср 1-(5-Фторурацилил-1) - - глюкофурануронова кислота или ее ацилзамещенный лактон,обладающие антибластическим действием
FR2428638A1 (fr) * 1978-06-15 1980-01-11 Aec Chim Organ Biolog Nouveau derive de la xylidine-3,4, sa preparation et son utilisation
CA1135258A (en) 1979-06-15 1982-11-09 Richard D'souza Process for the preparation of 5'deoxy-5-fluorouridine
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
US5141943A (en) * 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
US6593467B2 (en) 1997-05-23 2003-07-15 Clariant Finance (Bvi) Limited Process for the preparation of a deoxyuridine derivative
IT1291983B1 (it) * 1997-05-23 1999-01-25 Pro Bio Sint Srl Prodcedimento per la preparazione di un derivato della desossiuridina
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
DE69813231T2 (de) * 1997-06-03 2003-12-04 Itochu Techno-Chemical Inc., Tokio/Tokyo Natürliche antitumor- oder antivirale substanzen und ihre anwendung
CN1931869B (zh) * 2005-09-14 2011-05-11 上海瑞广生化科技开发有限公司 5’-脱氧-5-氟胞苷类衍生物，它的制备方法及其用途
CN105343029B (zh) * 2015-12-08 2018-10-12 上海朝晖药业有限公司 一种去氧氟尿苷胶囊及其制备方法
CA3108362A1 (en) * 2018-08-03 2020-02-06 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
CN113788839A (zh) * 2020-08-21 2021-12-14 诺茗(北京)生物医药有限公司 一种水溶性抗肿瘤前药及其药物组合物和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
JPS5545560B2 (es) * 1972-11-28 1980-11-18
JPS5726278B2 (es) * 1973-03-13 1982-06-03
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore

Also Published As

Publication number Publication date
GR70039B (es) 1982-07-26
BE861984A (fr) 1978-06-19
ZA777238B (en) 1978-09-27
DE2756653C2 (de) 1982-06-24
DK148745B (da) 1985-09-16
AU3149177A (en) 1979-06-21
US4071680A (en) 1978-01-31
IT1089318B (it) 1985-06-18
NL178878C (nl) 1986-06-02
MY8500246A (en) 1985-12-31
AU515446B2 (en) 1981-04-02
IL61311A0 (en) 1980-12-31
DK566777A (da) 1978-06-21
LU78717A1 (es) 1979-02-02
YU44478B (en) 1990-08-31
PT67429A (en) 1978-01-01
AR225410A1 (es) 1982-03-31
JPS5395982A (en) 1978-08-22
SE440361B (sv) 1985-07-29
DK531781A (da) 1981-11-30
FI773804A7 (fi) 1978-06-21
NZ185965A (en) 1979-03-28
FR2374334B1 (es) 1981-11-27
DK148745C (da) 1986-03-17
JPS5834479B2 (ja) 1983-07-27
JPS5936999B2 (ja) 1984-09-06
NO774375L (no) 1978-06-21
HU177104B (en) 1981-07-28
DK147858C (da) 1985-06-10
IL53589A0 (en) 1978-03-10
SE7714462L (sv) 1978-06-21
HK78284A (en) 1984-10-26
IE46107L (en) 1978-06-20
YU204984A (en) 1985-08-31
MC1174A1 (fr) 1978-09-25
CA1085390A (en) 1980-09-09
PH12784A (en) 1979-08-17
ES471584A1 (es) 1979-01-16
FI63946C (fi) 1983-09-12
NO145307C (no) 1982-02-24
IL53589A (en) 1981-05-20
YU302277A (en) 1983-01-21
ATA909577A (de) 1979-08-15
FR2374334A1 (fr) 1978-07-13
NL7714069A (nl) 1978-06-22
AR220692A1 (es) 1980-11-28
YU40688B (en) 1986-04-30
PT67429B (en) 1979-12-19
DK147858B (da) 1984-12-24
JPS5747000A (en) 1982-03-17
FI63946B (fi) 1983-05-31
IE46107B1 (en) 1983-02-23
DE2756653A1 (de) 1978-06-22
GB1589688A (en) 1981-05-20
NO145307B (no) 1981-11-16
AT355733B (de) 1980-03-25

Similar Documents

Publication Publication Date Title
ES471584A1 (es) Un procedimiento para la preparacion de un nucleosido piri- midinico
AR199463A1 (es) Sintesis de nucleosidos de 1,2,4-triazol-3-sustituidos
IT1085423B (it) Accumulatore termico per serre'
AR224097A1 (es) Colorantes 2,6-dioxo-2,6-dihidrobenzo(1,2-b:4,5-b1)-difuranos o dipirroles substitutidos y procedimientos para producirlos
DE3671896D1 (de) Herstellung von cytosin-nukleosiden.
DK130685B (da) Analogifremgangsmåde til fremstilling af purinnucleosid- eller -nucleotidderivater.
DK125247B (da) Fremgangsmåde til fremstilling af 9-(β-D-arabinofuranosyl)-adenin-5'-phospat eller salte heraf.
BE781791A (fr) Derives d'adenosine
ES492456A0 (es) Un procedimiento para la preparacion de 5'-deoxi-5-fluo- rouridina
DK630589D0 (da) 2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor-sammensaetning
JPS5325583A (en) Production of novel 5*66 dihydroocin *s**triazine nucleoside and nucleotide
TR19873A (tr) Deri ueretiminde,ince kisimli,suda coezuelmeyen alkali aluminyum silikat'larin kullanilmasi
ZA776519B (en) Process for the production of 9-(b-d-arabinofuranosyl)adenine,5'-phosphate
OA05351A (fr) Médicament à base de 5'thioéthers de l'adénosine.
IT1065395B (it) Processo per la preparazione di 1,1-dialogeno-4-metil-1,3-pentadieni
CH521973A (de) Verfahren zur Herstellung von cytostatisch wirksamen 2',3'-Didesoxy-3'-fluor-pyrimidin-nucleosiden
DK105061C (da) Fremgangsmåde til fremstilling af 5'-purin-nucleotider.
FR2883M (fr) Médicament a base de 3',5'-phosphate cyclique d'adénosine.
BE810629A (fr) Derives de monophosphate d'adenosine cyclique 2-substitues
CH555843A (de) Verfahren zur herstellung von s-substituierten 2-mercaptopyrido(2,3-d)-pyrimidin-4(3h)-onen.
IT7924044A0 (it) Dispositivo per sincronizzare il movimento di due o piu' organi.
SU582942A1 (ru) Устройство дл ориентации деталей по фаске
JPS5225088A (en) Process for preparing a novel thermoresistant acetate kinase
SU550435A1 (ru) Глиссажна опора
IT7819796A0 (it) Processo per produrre ceramiche policristalline d'alta densita'.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981107