ES465384A1 - Procedimiento para la obtencion de ciclopentan-1-aminas - Google Patents

Procedimiento para la obtencion de ciclopentan-1-aminas

Info

Publication number
ES465384A1
ES465384A1 ES465384A ES465384A ES465384A1 ES 465384 A1 ES465384 A1 ES 465384A1 ES 465384 A ES465384 A ES 465384A ES 465384 A ES465384 A ES 465384A ES 465384 A1 ES465384 A1 ES 465384A1
Authority
ES
Spain
Prior art keywords
atoms
alkyl
hydrogen
cyclopentan
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465384A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES465384A1 publication Critical patent/ES465384A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C07D303/06—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos de fórmula contienen 4 átomos de carbono asimétricos en el penta-anillo. Sin embargo, también se pueden presentar ulteriores centros de asimetría, por ejemplo cuando R3 significa un resto alquilo ramificado con 5 - 10 átomos de carbono, ó 2-hidroxialquilo con 5 - 10 átomos de carbono, o cuando R5 significa alquilo ramificado con 5 - 10 átomos de carbono, o -CnH2nC00R6 ramificado. Los compuestos de fórmula I se pueden presentar por lo tanto en un gran número de formas esterecisómeras; se presentan por regla general como mezcla racémicas junto con sus imágenes simétricas.
ES465384A 1976-12-23 1977-12-23 Procedimiento para la obtencion de ciclopentan-1-aminas Expired ES465384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762658401 DE2658401A1 (de) 1976-12-23 1976-12-23 Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel

Publications (1)

Publication Number Publication Date
ES465384A1 true ES465384A1 (es) 1979-01-01

Family

ID=5996379

Family Applications (2)

Application Number Title Priority Date Filing Date
ES465384A Expired ES465384A1 (es) 1976-12-23 1977-12-23 Procedimiento para la obtencion de ciclopentan-1-aminas
ES476343A Expired ES476343A1 (es) 1976-12-23 1978-12-26 Procedimiento para la obtencion de ciclopentan-1-aminas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES476343A Expired ES476343A1 (es) 1976-12-23 1978-12-26 Procedimiento para la obtencion de ciclopentan-1-aminas

Country Status (13)

Country Link
US (1) US4188403A (es)
JP (1) JPS5379844A (es)
AT (1) ATA922877A (es)
AU (1) AU3191677A (es)
BE (1) BE862231A (es)
DE (1) DE2658401A1 (es)
ES (2) ES465384A1 (es)
FR (1) FR2375187A1 (es)
GB (1) GB1547127A (es)
IL (1) IL53650A0 (es)
NL (1) NL7714258A (es)
SE (1) SE7714592L (es)
ZA (1) ZA777611B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3162659D1 (en) * 1980-07-22 1984-04-19 Ono Pharmaceutical Co 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof
CH646148A5 (de) * 1981-05-12 1984-11-15 Gyogyszerkutato Intezet 16-amino-prostaglandin-derivate und verfahren zu ihrer herstellung.
AU580777B2 (en) * 1984-05-18 1989-02-02 Glaxo Group Limited Aminocyclopentyl ethers and their preparation and pharmaceutical formulation
US5066824A (en) * 1990-05-15 1991-11-19 Mobay Corporation Novel process for the preparation of amine-terminated compounds
US5449830A (en) * 1994-03-11 1995-09-12 Marck & Co., Inc. Regiospecific processes to make CIS-1-Amino-2-Alkanol from Diol or Halohydrin
CN1217918C (zh) 1998-04-01 2005-09-07 卡迪欧梅制药公司 氨基环己基醚化合物和其用途
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
DE60305200T2 (de) 2003-05-02 2007-05-10 Cardiome Pharma Corp. Aminocyclohexylether-verbindungen und deren verwendung
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005097087A2 (en) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
CA2561819A1 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
JP5583325B2 (ja) 2004-11-08 2014-09-03 カーディオム ファーマ コーポレイション イオンチャネル調節化合物の投与レジメ
CN101321725B (zh) * 2005-12-22 2012-04-18 巴斯夫欧洲公司 制备o-烷基化氨基醇的方法
EP1966126A1 (de) * 2005-12-22 2008-09-10 Basf Se Verfahren zur herstellung von zyklischen o-alkylierten aminoalkoholen
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
DK3019503T3 (da) 2013-07-12 2017-11-20 Gilead Sciences Inc Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner
NO2865735T3 (es) 2013-07-12 2018-07-21
NO2717902T3 (es) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2244778C3 (de) * 1972-09-13 1975-02-20 Th. Goldschmidt Ag, 4300 Essen 1 -n-Dodecylaminomethyl-2-aminocyclopentan, dessen Herstellung und Verwendung als mikrobicider Wirkstoff
DE2259260A1 (de) * 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine

Also Published As

Publication number Publication date
US4188403A (en) 1980-02-12
JPS5379844A (en) 1978-07-14
IL53650A0 (en) 1978-03-10
FR2375187B1 (es) 1980-04-04
GB1547127A (en) 1979-06-06
ES476343A1 (es) 1979-10-16
NL7714258A (nl) 1978-06-27
FR2375187A1 (fr) 1978-07-21
AU3191677A (en) 1979-06-28
DE2658401A1 (de) 1978-07-06
BE862231A (nl) 1978-06-23
ZA777611B (en) 1978-10-25
ATA922877A (de) 1980-07-15
SE7714592L (sv) 1978-06-24

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