ES8301962A1 - Un procedimiento para la produccion de un derivado de carboslivilo. - Google Patents

Un procedimiento para la produccion de un derivado de carboslivilo.

Info

Publication number
ES8301962A1
ES8301962A1 ES500137A ES500137A ES8301962A1 ES 8301962 A1 ES8301962 A1 ES 8301962A1 ES 500137 A ES500137 A ES 500137A ES 500137 A ES500137 A ES 500137A ES 8301962 A1 ES8301962 A1 ES 8301962A1
Authority
ES
Spain
Prior art keywords
group
image
formula
same
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500137A
Other languages
English (en)
Other versions
ES500137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2880580A external-priority patent/JPS56125370A/ja
Priority claimed from JP11502280A external-priority patent/JPS5738772A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8301962A1 publication Critical patent/ES8301962A1/es
Publication of ES500137A0 publication Critical patent/ES500137A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO DE FORMULA (I), EN LA QUE B ES UN GRUPO ALQUILENO INFERIOR; R , A Y Z PUEDEN SER VARIOS TIPOS DE RADICALES; A VALE 0 O 1; Y LA LINEA DISCONTINUA INDICA UN ENLACE DOBLE O SENCILLO. CONSISTE EN LA REACCION DE SUSTITUCION ENTRE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X ES UN HALOGENO O UN DERIVADO DE SULFONILOXI, CON UN COMPUESTO DE FORMULA (III), EN LA QUE Z ES EL MISMO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO SIN DISOLVENTE O EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE COMO AGENTE ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 200<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHISTAMINICOS Y COMO CONTROLADORES DEL SISTEMA NERVIOSO CENTRAL.
ES500137A 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo. Granted ES500137A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (2)

Publication Number Publication Date
ES8301962A1 true ES8301962A1 (es) 1982-11-01
ES500137A0 ES500137A0 (es) 1982-11-01

Family

ID=26366952

Family Applications (4)

Application Number Title Priority Date Filing Date
ES500137A Granted ES500137A0 (es) 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo.
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Granted ES509658A0 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Granted ES518667A0 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Granted ES509658A0 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Granted ES518667A0 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Country Status (21)

Country Link
US (4) US4460593A (es)
AT (1) AT381307B (es)
AU (1) AU523005B2 (es)
BE (1) BE887800A (es)
CA (1) CA1155119A (es)
CH (1) CH647775A5 (es)
DE (2) DE3107601A1 (es)
DK (1) DK155282C (es)
ES (4) ES500137A0 (es)
FI (1) FI76323C (es)
FR (1) FR2477542A1 (es)
GB (1) GB2071094B (es)
IT (1) IT1144315B (es)
MX (1) MX6980E (es)
NL (1) NL184364C (es)
NO (1) NO159531C (es)
PH (1) PH17194A (es)
PT (1) PT72622B (es)
RU (1) RU1779249C (es)
SE (1) SE447255B (es)
SU (1) SU1367857A3 (es)

Families Citing this family (57)

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PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3509131A1 (de) * 1985-03-14 1986-09-18 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zur justierten montage der optischen bauteile eines optischen geraetes
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4886809A (en) * 1986-07-31 1989-12-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
DE3802030A1 (de) * 1988-01-25 1989-07-27 Hoechst Ag Makroporoese, asymmetrische, hydrophile membran aus polyaramid
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
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FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
CZ284133B6 (cs) * 1991-07-17 1998-08-12 Pfizer Inc. 2-/4-Hydroxypiperidino/-1-alkanolové deriváty jako antiischemická činidla. způsob jejich přípravy a použití.
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
CN1052224C (zh) * 1993-04-07 2000-05-10 大塚制药株式会社 哌啶衍生物、含有它的外周血管舒张剂及其应用
DE59504622D1 (de) * 1994-10-31 1999-02-04 Merck Patent Gmbh Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
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FR2823749B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
AU2003218737B2 (en) 2002-03-13 2008-04-10 Janssen Pharmaceutica N.V. Inhibitors of histone deacetylase
ES2306880T3 (es) 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa.
EA007270B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н.В. Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы
CA2476067C (en) 2002-03-13 2011-09-20 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
PL1781639T3 (pl) * 2004-07-28 2012-07-31 Janssen Pharmaceutica Nv Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej
PL1776358T3 (pl) * 2004-07-28 2009-10-30 Janssen Pharmaceutica Nv Pochodne podstawionej propenylopiperazyny jako nowe inhibitory deacetylazy histonowej
UA86066C2 (ru) * 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AU2006248938B2 (en) 2005-05-18 2011-09-29 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
CA2635015C (en) * 2006-01-19 2014-06-03 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
DE602007001190D1 (de) * 2006-01-19 2009-07-09 Janssen Pharmaceutica Nv Aminophenylderivate als neue inhibitoren von histondeacetylase
US8101616B2 (en) * 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
JP5247470B2 (ja) * 2006-01-19 2013-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
WO2007099828A1 (ja) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. 環式基で置換された含窒素複素環誘導体
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
DK2400968T3 (da) 2009-02-26 2017-01-02 Reviva Pharmaceuticals Inc Sammensætninger, syntese og fremgangsmåder til anvendelse af arylpiperazinderivater
CA2872883A1 (en) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN108031471A (zh) * 2017-10-27 2018-05-15 苏州盖德精细材料有限公司 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用
CN114409680B (zh) * 2018-01-19 2023-11-21 上海怡立舍生物技术有限公司 Ppar激动剂及其应用
CN116554127B (zh) * 2022-01-28 2025-03-21 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途

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Also Published As

Publication number Publication date
DE3152880C2 (es) 1990-03-22
NL184364C (nl) 1989-07-03
BE887800A (fr) 1981-09-07
NL8101099A (nl) 1981-10-01
SU1367857A3 (ru) 1988-01-15
US4567187A (en) 1986-01-28
IT1144315B (it) 1986-10-29
GB2071094A (en) 1981-09-16
SE447255B (sv) 1986-11-03
AU523005B2 (en) 1982-07-08
DE3107601A1 (de) 1982-02-04
ES8405782A1 (es) 1984-06-16
DK155282B (da) 1989-03-20
FI76323B (fi) 1988-06-30
MX6980E (es) 1987-01-19
NO810765L (no) 1981-09-07
NO159531C (no) 1989-01-11
DK155282C (da) 1989-08-07
FR2477542B1 (es) 1983-09-09
US4460593A (en) 1984-07-17
NO159531B (no) 1988-10-03
US4619932A (en) 1986-10-28
ES8305356A1 (es) 1983-04-01
RU1779249C (ru) 1992-11-30
US4455422A (en) 1984-06-19
AU6797381A (en) 1981-09-10
ES509659A0 (es) 1983-05-01
AT381307B (de) 1986-09-25
FI810669L (fi) 1981-09-07
DK99781A (da) 1981-09-07
ES8306141A1 (es) 1983-05-01
FI76323C (fi) 1988-10-10
GB2071094B (en) 1984-09-26
ATA98481A (de) 1986-02-15
DE3107601C2 (es) 1989-07-20
ES518667A0 (es) 1984-06-16
SE8101409L (sv) 1981-09-07
CA1155119A (en) 1983-10-11
PT72622A (en) 1981-04-01
ES509658A0 (es) 1983-04-01
PT72622B (en) 1982-06-15
CH647775A5 (de) 1985-02-15
NL184364B (nl) 1989-02-01
PH17194A (en) 1984-06-19
FR2477542A1 (fr) 1981-09-11
IT8167311A0 (it) 1981-03-05
ES500137A0 (es) 1982-11-01

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