ES471349A1 - Un procedimiento para la preparacion de un compuesto de pi- rrolidona - Google Patents

Un procedimiento para la preparacion de un compuesto de pi- rrolidona

Info

Publication number
ES471349A1
ES471349A1 ES471349A ES471349A ES471349A1 ES 471349 A1 ES471349 A1 ES 471349A1 ES 471349 A ES471349 A ES 471349A ES 471349 A ES471349 A ES 471349A ES 471349 A1 ES471349 A1 ES 471349A1
Authority
ES
Spain
Prior art keywords
phenyl
group
tetrazol
carbon atoms
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471349A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES471349A1 publication Critical patent/ES471349A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de un compuesto de pirrolidona de la fórmula: **(Fórmula)** y el epímero de C5 del mismo, en donde: Q es un grupo de la fórmula -COOR'', tetrazol-5-ilo, N-(aciloximetil)tetrazol-5-ilo que tiene de dos a cinco átomos de carbono en el grupo aciloxi, N-(ftalidil)tetrazol-5-ilo; N-(tetrahidropiran-2-il)tetrazol-5-ilo y -CONHR"; W es un enlace sencillo o un enlace doble cis; Z es un enlace sencillo o un enlace doble trans; R es alfatienilo, fenilo, fenoxi, fenilo monosustituido y fenoxi monosustituido, en los que los sustituyentes se seleccionan del grupo que consiste en cloro, flú or, fenilo, metoxi, trifluorometilo y alquilo que tiene de uno a tres átomos de carbono; R'' es hidrógeno, alquilo que tiene de uno a cinco átomos de carbono, fenilo y p-bifenilo; y R" se selecciona del grupo que consiste en -COR'''''' y -SO2R'''''', donde R'''''' se selecciona del grupo que consiste en fenilo y alquilo que tiene de uno a cinco átomos de carbono.
ES471349A 1976-08-06 1978-07-01 Un procedimiento para la preparacion de un compuesto de pi- rrolidona Expired ES471349A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71236276A 1976-08-06 1976-08-06

Publications (1)

Publication Number Publication Date
ES471349A1 true ES471349A1 (es) 1979-09-16

Family

ID=24861795

Family Applications (2)

Application Number Title Priority Date Filing Date
ES461388A Expired ES461388A1 (es) 1976-08-06 1977-08-05 Un procedimiento para la preparacion de un compuesto de pi- rrolidona.
ES471349A Expired ES471349A1 (es) 1976-08-06 1978-07-01 Un procedimiento para la preparacion de un compuesto de pi- rrolidona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES461388A Expired ES461388A1 (es) 1976-08-06 1977-08-05 Un procedimiento para la preparacion de un compuesto de pi- rrolidona.

Country Status (31)

Country Link
JP (2) JPS5321159A (es)
AR (1) AR217080A1 (es)
AT (1) AT362887B (es)
AU (1) AU508007B2 (es)
BE (1) BE857506A (es)
BG (1) BG31073A3 (es)
CA (1) CA1077948A (es)
CH (1) CH624934A5 (es)
CS (1) CS221269B2 (es)
DD (2) DD143768A5 (es)
DE (1) DE2735904A1 (es)
DK (1) DK352077A (es)
ES (2) ES461388A1 (es)
FI (1) FI70009C (es)
FR (1) FR2369260A1 (es)
GB (2) GB1556570A (es)
GR (1) GR68688B (es)
HU (1) HU180273B (es)
IE (1) IE45505B1 (es)
IL (1) IL52615A (es)
LU (1) LU77936A1 (es)
NL (1) NL7708637A (es)
NO (1) NO772752L (es)
NZ (1) NZ184806A (es)
PH (1) PH17398A (es)
PL (2) PL112931B1 (es)
PT (1) PT66891B (es)
SE (1) SE423813B (es)
SU (3) SU703016A3 (es)
YU (1) YU192577A (es)
ZA (1) ZA774704B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5695569A (en) * 1979-12-27 1981-08-03 Canon Inc Forming method for bar lens sphere face
US4321201A (en) * 1980-09-22 1982-03-23 E. I. Du Pont De Nemours And Company Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) heptanoates
PT1132086E (pt) * 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
AU2001290250A1 (en) * 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
NZ525164A (en) * 2000-11-27 2005-04-29 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis
CN101921220B (zh) * 2001-07-23 2013-05-22 小野药品工业株式会社 治疗与骨质损失有关的疾病的含有ep4激动剂作为活性成分的药物组合物
WO2003077910A1 (en) * 2002-03-18 2003-09-25 Pfizer Products Inc. Methods of treatment with selective ep4 receptor agonists
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
WO2004065365A1 (ja) * 2003-01-21 2004-08-05 Ono Pharmaceutical Co., Ltd. ８−アザプロスタグランジン誘導体およびその医薬用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1386146A (en) * 1972-05-03 1975-03-05 Ici Ltd Cyclopentane derivatives
JPS511460A (en) * 1974-06-24 1976-01-08 Tanabe Seiyaku Co 22 piroridonjudotaino seiho
JPS514166A (ja) * 1974-06-28 1976-01-14 Tanabe Seiyaku Co 22piroridonjudotaino seiho
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
DE2528664A1 (de) * 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PT66891B (en) 1979-01-26
FI70009B (fi) 1986-01-31
GR68688B (es) 1982-02-01
SE423813B (sv) 1982-06-07
NL7708637A (nl) 1978-02-08
JPS5321159A (en) 1978-02-27
FI772376A7 (es) 1978-02-07
ES461388A1 (es) 1978-12-01
SU818480A3 (ru) 1981-03-30
GB1556569A (en) 1979-11-28
BE857506A (fr) 1978-02-06
SE7708642L (sv) 1978-02-07
IE45505L (en) 1978-02-06
DE2735904A1 (de) 1978-02-09
SU850000A3 (ru) 1981-07-23
ATA579477A (de) 1980-11-15
IL52615A0 (en) 1977-10-31
NO772752L (no) 1978-02-07
JPS5531147B2 (es) 1980-08-15
AU2751577A (en) 1979-02-08
FR2369260B1 (es) 1982-02-12
JPS585196B2 (ja) 1983-01-29
AR217080A1 (es) 1980-02-29
FI70009C (fi) 1986-09-12
CA1077948A (en) 1980-05-20
JPS5555161A (en) 1980-04-22
DK352077A (da) 1978-02-07
ZA774704B (en) 1978-06-28
HU180273B (en) 1983-02-28
DD136135A5 (de) 1979-06-20
AU508007B2 (en) 1980-03-06
AT362887B (de) 1981-06-25
BG31073A3 (bg) 1981-10-15
PL112931B1 (en) 1980-11-29
GB1556570A (en) 1979-11-28
IL52615A (en) 1981-09-13
NZ184806A (en) 1980-04-28
IE45505B1 (en) 1982-09-08
DD143768A5 (de) 1980-09-10
SU703016A3 (ru) 1979-12-05
YU192577A (en) 1983-04-30
FR2369260A1 (fr) 1978-05-26
CS221269B2 (en) 1983-04-29
PT66891A (en) 1977-09-01
LU77936A1 (es) 1978-04-27
CH624934A5 (es) 1981-08-31
PL200124A1 (pl) 1978-05-22
PH17398A (en) 1984-08-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201