ES472290A1 - Un procedimiento para preparar un compuesto de benceno di- sustituido en orto - Google Patents
Un procedimiento para preparar un compuesto de benceno di- sustituido en ortoInfo
- Publication number
- ES472290A1 ES472290A1 ES472290A ES472290A ES472290A1 ES 472290 A1 ES472290 A1 ES 472290A1 ES 472290 A ES472290 A ES 472290A ES 472290 A ES472290 A ES 472290A ES 472290 A1 ES472290 A1 ES 472290A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group containing
- diorthosubstituted
- therapy
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- -1 ortho-disubstituted benzene compound Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para preparar un compuesto de benceno disustituido en orto, caracterizado por el hecho de que un compuesto de la fórmula general: **(Fórmula)** en la que R1 y R2 representan cada uno de ellos independientemente un grupo alcohilo que contiene 1 a 4 átomos de carbono o un grupo alcoxi que contiene 1 a 3 átomos de carbono, halógeno, R3 representa hidrógeno, halógeno, un grupo alcohilo que contiene 1 a 4 átomos de carbono, un grupo alcoxi que contiene 1 a 3 átomos de carbono, un grupo amino o un grupo nitro, A representa -SO2NR4, que está unido al anillo de benceno por su átomo de azufre o de nitrógeno y en el que R4 es hidrógeno o un grupo alcohilo que contiene 1 a 4 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3294677 | 1977-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES472290A1 true ES472290A1 (es) | 1979-02-16 |
Family
ID=10346357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472290A Expired ES472290A1 (es) | 1977-08-05 | 1978-08-02 | Un procedimiento para preparar un compuesto de benceno di- sustituido en orto |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4218476A (es) |
| EP (1) | EP0000826A1 (es) |
| JP (1) | JPS5444635A (es) |
| AU (1) | AU3857778A (es) |
| DK (1) | DK340178A (es) |
| ES (1) | ES472290A1 (es) |
| FI (1) | FI782383A7 (es) |
| IT (1) | IT1099585B (es) |
| NO (1) | NO782650L (es) |
| NZ (1) | NZ188038A (es) |
| PT (1) | PT68382A (es) |
| ZA (1) | ZA784348B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396628A (en) * | 1981-06-18 | 1983-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Antiviral activities of dansylcadaverine and closely related compounds |
| US4968494A (en) * | 1987-03-27 | 1990-11-06 | Merck & Co., Inc. | Methods and compositions for thrombolytic therapy |
| US5185149A (en) * | 1987-03-27 | 1993-02-09 | Merck & Co., Inc. | Methods for thrombolytic therapy |
| EP0294016A3 (en) * | 1987-03-27 | 1991-06-26 | Merck & Co. Inc. | Factor xiiia inhibitor compounds useful for thrombolytic therapy |
| DE3821540A1 (de) * | 1988-06-25 | 1989-12-28 | Boehringer Mannheim Gmbh | Neue sulfonamide, verfahren zu ihrer herstellung sowie solche sulfonamide enthaltende arzneimittel |
| US5019572A (en) * | 1990-02-07 | 1991-05-28 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| US5077285A (en) * | 1989-07-31 | 1991-12-31 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| US4968713A (en) * | 1989-07-31 | 1990-11-06 | Merck & Co., Inc. | Certain imidazole compounds as transglutaminase inhibitors |
| US5021440A (en) * | 1989-07-31 | 1991-06-04 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| US5047416A (en) * | 1989-07-31 | 1991-09-10 | Merck & Co., Inc. | Triazole compounds and their use as transglutaminase inhibitors |
| US5030644A (en) * | 1989-07-31 | 1991-07-09 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| RU2662308C1 (ru) * | 2017-12-25 | 2018-07-25 | Феркат Адельзянович Халиуллин | Средство для лечения и профилактики тромбоза |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1238350A (fr) * | 1959-06-30 | 1960-08-12 | Inst Nat Rech Chimique | Procédé d'obtention d'amines sulfurées |
| US3895010A (en) * | 1972-12-13 | 1975-07-15 | Dow Chemical Co | 1-(Arylthio)methanesulfonamides |
| JPS5829784B2 (ja) * | 1975-08-22 | 1983-06-24 | 萬有製薬株式会社 | オメガ − （ アリ−ルスルホンアミド ）− アルキルアミンノ セイホウ |
| US4098889A (en) * | 1977-09-01 | 1978-07-04 | The Dow Chemical Company | Antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides |
-
1978
- 1978-08-01 DK DK340178A patent/DK340178A/da unknown
- 1978-08-01 ZA ZA00784348A patent/ZA784348B/xx unknown
- 1978-08-01 EP EP78300227A patent/EP0000826A1/en not_active Withdrawn
- 1978-08-02 NZ NZ188038A patent/NZ188038A/xx unknown
- 1978-08-02 IT IT26405/78A patent/IT1099585B/it active
- 1978-08-02 ES ES472290A patent/ES472290A1/es not_active Expired
- 1978-08-02 NO NO782650A patent/NO782650L/no unknown
- 1978-08-02 AU AU38577/78A patent/AU3857778A/en active Pending
- 1978-08-02 FI FI782383A patent/FI782383A7/fi not_active Application Discontinuation
- 1978-08-03 JP JP9500178A patent/JPS5444635A/ja active Pending
- 1978-08-03 US US05/930,614 patent/US4218476A/en not_active Expired - Lifetime
- 1978-08-03 PT PT68382A patent/PT68382A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3857778A (en) | 1980-02-07 |
| IT7826405A0 (it) | 1978-08-02 |
| IT1099585B (it) | 1985-09-18 |
| NO782650L (no) | 1979-02-06 |
| EP0000826A1 (en) | 1979-02-21 |
| NZ188038A (en) | 1981-02-11 |
| FI782383A7 (fi) | 1979-02-06 |
| JPS5444635A (en) | 1979-04-09 |
| US4218476A (en) | 1980-08-19 |
| ZA784348B (en) | 1979-07-25 |
| PT68382A (en) | 1978-09-01 |
| DK340178A (da) | 1979-02-06 |
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