ES472297A1 - 1-Methylisoguanosin, processes and intermediates for its preparation, its pharmaceutical compositions and their preparation. - Google Patents

1-Methylisoguanosin, processes and intermediates for its preparation, its pharmaceutical compositions and their preparation.

Info

Publication number
ES472297A1
ES472297A1 ES472297A ES472297A ES472297A1 ES 472297 A1 ES472297 A1 ES 472297A1 ES 472297 A ES472297 A ES 472297A ES 472297 A ES472297 A ES 472297A ES 472297 A1 ES472297 A1 ES 472297A1
Authority
ES
Spain
Prior art keywords
preparation
isoguanosine
methyl
sponges
methylisoguanosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472297A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/876,768 external-priority patent/US4148993A/en
Priority claimed from GB7826761A external-priority patent/GB2001955A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES472297A1 publication Critical patent/ES472297A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se ha descubierto que la 1-metil-isoguanosina está contenida en bajas cantidades en organismos marinos, particularmente en esponjas pertenecientes al género Tedania, que pueden recogerse en las costas marítimas australianas. Por consiguiente, el invento se refiere en un aspecto al aislamiento de 1-metil-isoguanosina de fuentes naturales, particularmente de organismos marinos, especialmente esponjas del género Tedania. Por consiguiente constituye una característica adicional del presente invento la 1-metil-isoguanosina en forma sustancialmente pura, o sea libre de sub-productos que se encuentran en estado natural. La 1-metil-isoguanosina puede aislarse de la fuente natural, por ejemplo de esponjas, por ejemplo mediante extracción con DMSO, agua y/o un disolvente hidroxílico orgánico, tal como un alcanol inferior, por ejemplo metanol o etanol.1-Methyl-isoguanosine has been found to be contained in low amounts in marine organisms, particularly sponges belonging to the genus Tedania, which can be collected from Australian seacoasts. Accordingly, the invention relates in one aspect to the isolation of 1-methyl-isoguanosine from natural sources, particularly from marine organisms, especially sponges of the genus Tedania. Therefore, an additional feature of the present invention is 1-methyl-isoguanosine in substantially pure form, that is, free of naturally occurring by-products. 1-Methyl-isoguanosine can be isolated from the natural source, eg from sponges, for example by extraction with DMSO, water and/or an organic hydroxyl solvent, such as a lower alkanol, eg methanol or ethanol.

ES472297A 1977-08-03 1978-08-02 1-Methylisoguanosin, processes and intermediates for its preparation, its pharmaceutical compositions and their preparation. Expired ES472297A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU77910 1977-08-03
US87676978A 1978-02-10 1978-02-10
US05/876,768 US4148993A (en) 1978-02-10 1978-02-10 Process to produce 1-methyl isoguanosine
GB7826761A GB2001955A (en) 1977-08-03 1978-06-13 1-Methyl-isoguanine

Publications (1)

Publication Number Publication Date
ES472297A1 true ES472297A1 (en) 1979-02-16

Family

ID=27449076

Family Applications (1)

Application Number Title Priority Date Filing Date
ES472297A Expired ES472297A1 (en) 1977-08-03 1978-08-02 1-Methylisoguanosin, processes and intermediates for its preparation, its pharmaceutical compositions and their preparation.

Country Status (14)

Country Link
EP (1) EP0000770A3 (en)
JP (1) JPS5448794A (en)
AU (1) AU3840678A (en)
DE (1) DE2833887A1 (en)
DK (1) DK343578A (en)
ES (1) ES472297A1 (en)
FI (1) FI782298A7 (en)
FR (1) FR2399441A1 (en)
IL (1) IL55240A0 (en)
IT (1) IT1202760B (en)
MC (1) MC1200A1 (en)
NO (1) NO782648L (en)
PT (1) PT68377A (en)
SE (1) SE7808350L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108864234B (en) * 2018-07-06 2020-06-26 厦门医学院 A method for isolating inosine from sea squirt

Also Published As

Publication number Publication date
SE7808350L (en) 1979-02-04
FI782298A7 (en) 1979-02-04
IT7826445A0 (en) 1978-08-03
DK343578A (en) 1979-02-04
EP0000770A2 (en) 1979-02-21
DE2833887A1 (en) 1979-02-22
IL55240A0 (en) 1978-09-29
AU3840678A (en) 1980-01-31
EP0000770A3 (en) 1979-06-13
IT1202760B (en) 1989-02-09
FR2399441A1 (en) 1979-03-02
MC1200A1 (en) 1979-03-19
PT68377A (en) 1978-09-01
NO782648L (en) 1979-02-06
JPS5448794A (en) 1979-04-17

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