ES472699A1 - Un procedimiento para la preparacion de 5-(p-hidroxifenil)- hidantoina - Google Patents
Un procedimiento para la preparacion de 5-(p-hidroxifenil)- hidantoinaInfo
- Publication number
- ES472699A1 ES472699A1 ES472699A ES472699A ES472699A1 ES 472699 A1 ES472699 A1 ES 472699A1 ES 472699 A ES472699 A ES 472699A ES 472699 A ES472699 A ES 472699A ES 472699 A1 ES472699 A1 ES 472699A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxyphenyl
- hydantoin
- compounds
- preparation
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940091173 hydantoin Drugs 0.000 title abstract 2
- KKLMJYDGZSAIQX-UHFFFAOYSA-N 2-(n-hydroxyanilino)acetic acid Chemical compound OC(=O)CN(O)C1=CC=CC=C1 KKLMJYDGZSAIQX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- -1 hydroxyphenyl hydantoin Chemical compound 0.000 title 1
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 abstract 2
- UMTNMIARZPDSDI-UHFFFAOYSA-N 5-(4-hydroxyphenyl)imidazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1C1C(=O)NC(=O)N1 UMTNMIARZPDSDI-UHFFFAOYSA-N 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- WRUZLCLJULHLEY-UHFFFAOYSA-N N-(p-hydroxyphenyl)glycine Chemical compound OC(=O)CNC1=CC=C(O)C=C1 WRUZLCLJULHLEY-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000007073 chemical hydrolysis Effects 0.000 abstract 1
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la preparación de 5-(p-hidroxifenil)hidantoina de fórmula (I): **fórmula** cuyo procedimiento consiste en hacer reaccionar fenol con ácido glioxílico y urea, en presencia de un catalizador ácido en un medio acuoso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3480377 | 1977-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES472699A1 true ES472699A1 (es) | 1979-11-01 |
Family
ID=10370121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472699A Expired ES472699A1 (es) | 1977-08-18 | 1978-08-18 | Un procedimiento para la preparacion de 5-(p-hidroxifenil)- hidantoina |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0001319A1 (es) |
| JP (1) | JPS5441876A (es) |
| DK (1) | DK364578A (es) |
| ES (1) | ES472699A1 (es) |
| IL (1) | IL55343A0 (es) |
| IT (1) | IT1106888B (es) |
| ZA (1) | ZA784416B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2104894B (en) * | 1981-08-26 | 1985-10-16 | Pacific Chem Ind Co | 5-(4-hydroxyphenyl) hydantoin derivatives |
| ES2018743A6 (es) * | 1989-11-29 | 1991-05-01 | Etilo Derivados | Un procedimiento para la preparacion de 5-(4-hidroxifenil) hidantoina. |
| AU6612990A (en) * | 1989-12-14 | 1991-07-18 | Hoechst Celanese Corporation | Production of 5-(4'-hydroxyphenyl)hydantoin and d-p-hydroxyphenylglycine from 4-hydroxyacetophenone |
| ES2108350T3 (es) * | 1993-10-06 | 1997-12-16 | Showa Denko Kk | Procedimiento para la preparacion de 5-arilhidantoinas. |
| CN105562082B (zh) * | 2016-02-04 | 2018-07-24 | 吕梁学院 | 磺化醋糟、及其制备方法与应用 |
| PL3429622T3 (pl) | 2016-03-14 | 2021-11-02 | Biotest Ag | Leczenie ciężkiego pozaszpitalnego zapalenia płuc |
| CN112457256B (zh) * | 2020-11-20 | 2022-08-05 | 杭州新桂实业有限公司 | 一种dl-对羟基苯海因的制备方法 |
| CN119707825A (zh) * | 2024-12-24 | 2025-03-28 | 合肥菁科生物科技有限公司 | 一种对羟基苯海因的晶型及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3668221A (en) * | 1966-07-28 | 1972-06-06 | Sumitomo Chemical Co | A process for producing {60 -amino acids |
| GB1310510A (en) * | 1969-06-10 | 1973-03-21 | Zundel J | Preparation of alpha-aminoacids from hydantoins |
| GB1353612A (en) * | 1970-07-11 | 1974-05-22 | Sterling Winthrop Group Ltd | Process for the preparation of a glycine derivative |
| IT1046399B (it) * | 1975-05-12 | 1980-06-30 | Snam Progetti | Procedimento per la preparazione di d carbamil amminoacidi e dei corrispondenti d amminoacidi |
| IT1039757B (it) * | 1975-07-10 | 1979-12-10 | Snam Progetti | Complessi enzimatici atti a trasformare idantoine raceme in am minoacidi otticamente attivi e loro applicazione |
-
1978
- 1978-07-31 EP EP78300214A patent/EP0001319A1/en not_active Withdrawn
- 1978-08-03 ZA ZA00784416A patent/ZA784416B/xx unknown
- 1978-08-11 IL IL7855343A patent/IL55343A0/xx unknown
- 1978-08-16 IT IT50741/78A patent/IT1106888B/it active
- 1978-08-17 DK DK364578A patent/DK364578A/da unknown
- 1978-08-18 ES ES472699A patent/ES472699A1/es not_active Expired
- 1978-08-18 JP JP10137378A patent/JPS5441876A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL55343A0 (en) | 1978-10-31 |
| ZA784416B (en) | 1979-07-25 |
| DK364578A (da) | 1979-02-19 |
| IT7850741A0 (it) | 1978-08-16 |
| IT1106888B (it) | 1985-11-18 |
| JPS5441876A (en) | 1979-04-03 |
| EP0001319A1 (en) | 1979-04-04 |
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