ES473121A1 - Un procedimiento para preparar productos de copulacion entrecitidina-difosfocolina y de compuestos aminados - Google Patents
Un procedimiento para preparar productos de copulacion entrecitidina-difosfocolina y de compuestos aminadosInfo
- Publication number
- ES473121A1 ES473121A1 ES473121A ES473121A ES473121A1 ES 473121 A1 ES473121 A1 ES 473121A1 ES 473121 A ES473121 A ES 473121A ES 473121 A ES473121 A ES 473121A ES 473121 A1 ES473121 A1 ES 473121A1
- Authority
- ES
- Spain
- Prior art keywords
- cytidine
- diphosphocholine
- amino compounds
- pharmaceutical
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 title abstract 3
- 229960001284 citicoline Drugs 0.000 title abstract 3
- 230000008878 coupling Effects 0.000 title abstract 3
- 238000010168 coupling process Methods 0.000 title abstract 3
- 238000005859 coupling reaction Methods 0.000 title abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 244000045947 parasite Species 0.000 abstract 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
- NJNWCIAPVGRBHO-UHFFFAOYSA-N 2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical group OCC[N+](C)(C)C#P=O NJNWCIAPVGRBHO-UHFFFAOYSA-N 0.000 abstract 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- -1 amino compound Chemical class 0.000 abstract 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/822—Protozoa
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/857—Fish; fish eggs; shell fish; crustacea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedimiento para preparar productos de copulación entre citidina-difosfocolina y compuestos aminados, estando caracterizado dicho procedimiento porque consiste en: a) oxidar la citidina-difosfocolina; b) fijar el dialdehido, obtenido por la oxidación precedente de la ribosa de la citidina, sobre los grupos NH2 del compuesto aminado en solución acuosa alcalina; c) estabilizar la copulación así obtenida por reducción; d) recuperar el producto macromolecular así obtenido en forma de una solución acuosa, la cual puede ser liofilizada para proporcionar un polvo apto para la conservación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7727151A FR2402664A1 (fr) | 1977-09-07 | 1977-09-07 | Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473121A1 true ES473121A1 (es) | 1979-04-01 |
Family
ID=9195150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473121A Expired ES473121A1 (es) | 1977-09-07 | 1978-09-06 | Un procedimiento para preparar productos de copulacion entrecitidina-difosfocolina y de compuestos aminados |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4203893A (es) |
| EP (1) | EP0001197B1 (es) |
| AR (1) | AR225735A1 (es) |
| AU (1) | AU517557B2 (es) |
| BR (1) | BR7805863A (es) |
| CA (1) | CA1127985A (es) |
| DE (1) | DE2861284D1 (es) |
| DK (1) | DK393678A (es) |
| ES (1) | ES473121A1 (es) |
| FR (1) | FR2402664A1 (es) |
| IE (1) | IE47742B1 (es) |
| IT (1) | IT1160631B (es) |
| NZ (1) | NZ188353A (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| FR2523311B1 (fr) * | 1982-03-12 | 1985-12-27 | Pasteur Institut | Produit de couplage entre une albumine et un ligand specifique, obtention et applications dans le domaine biologique |
| US4470967A (en) * | 1982-10-05 | 1984-09-11 | Iowa State University Research Foundation | Lectin-containing anti-viral vaccines for domestic animals and method of preparation |
| FR2557458B1 (fr) * | 1983-12-30 | 1987-09-04 | Centre Nat Rech Scient | Nouveaux anticorps capables de reconnaitre specifiquement des groupements hapteniques, leur preparation et leur application, et nouveaux antigenes permettant de les preparer |
| IT1201474B (it) * | 1985-10-01 | 1989-02-02 | Vincenzo Zappia | Derivati macromolecolarizzati di cdp-colina,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| CA1330378C (en) * | 1986-05-08 | 1994-06-21 | Daniel J. Coughlin | Amine derivatives of folic acid analogs |
| US4968742A (en) * | 1987-11-09 | 1990-11-06 | Miles Inc. | Preparation of ligand-polymer conjugate having a controlled number of introduced ligands |
| WO1990012632A1 (en) * | 1989-04-19 | 1990-11-01 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Process for removing c-reactive protein and anti-phosphorylcholine antibodies from biological fluids |
| DD298884A5 (de) * | 1990-07-10 | 1992-03-19 | Charite Der Humboldt-Universitaet,De | Impfstoffe gegen virale antigene und verfahren zu ihrer herstellung |
| JP4245336B2 (ja) * | 2002-11-25 | 2009-03-25 | 株式会社資生堂 | ホスホリルコリン基を有するポリシロキサン及びその製造方法 |
| ATE463254T1 (de) | 2004-04-15 | 2010-04-15 | Athera Biotechnologies Ab | Antikörper gegen phosphorylcholinkonjugate |
| CN103906532B (zh) | 2011-08-09 | 2018-01-26 | 阿瑟拉生物技术公司 | 结合磷酰胆碱（pc）和/或pc结合物的抗体 |
| HUE045163T2 (hu) | 2011-08-09 | 2019-12-30 | Athera Biotechnologies Ab | Új ellenanyagok foszforilkolin ellen |
-
1977
- 1977-09-07 FR FR7727151A patent/FR2402664A1/fr active Granted
-
1978
- 1978-08-30 US US05/937,972 patent/US4203893A/en not_active Expired - Lifetime
- 1978-09-04 IE IE1779/78A patent/IE47742B1/en unknown
- 1978-09-05 AR AR273580A patent/AR225735A1/es active
- 1978-09-05 EP EP78400090A patent/EP0001197B1/fr not_active Expired
- 1978-09-05 IT IT69041/78A patent/IT1160631B/it active
- 1978-09-05 DE DE7878400090T patent/DE2861284D1/de not_active Expired
- 1978-09-06 BR BR7805863A patent/BR7805863A/pt unknown
- 1978-09-06 AU AU39617/78A patent/AU517557B2/en not_active Expired
- 1978-09-06 DK DK393678A patent/DK393678A/da not_active Application Discontinuation
- 1978-09-06 NZ NZ188353A patent/NZ188353A/xx unknown
- 1978-09-06 CA CA310,742A patent/CA1127985A/en not_active Expired
- 1978-09-06 ES ES473121A patent/ES473121A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU517557B2 (en) | 1981-08-06 |
| BR7805863A (pt) | 1979-05-02 |
| DK393678A (da) | 1979-03-08 |
| AU3961778A (en) | 1980-03-13 |
| US4203893A (en) | 1980-05-20 |
| DE2861284D1 (en) | 1982-01-14 |
| IT7869041A0 (it) | 1978-09-05 |
| AR225735A1 (es) | 1982-04-30 |
| IE781779L (en) | 1979-03-07 |
| EP0001197B1 (fr) | 1981-11-04 |
| FR2402664A1 (fr) | 1979-04-06 |
| EP0001197A2 (fr) | 1979-03-21 |
| IE47742B1 (en) | 1984-06-13 |
| FR2402664B1 (es) | 1980-12-26 |
| NZ188353A (en) | 1981-03-16 |
| IT1160631B (it) | 1987-03-11 |
| CA1127985A (en) | 1982-07-20 |
| EP0001197A3 (en) | 1979-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971201 |