ES475083A1 - Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico. - Google Patents
Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico.Info
- Publication number
- ES475083A1 ES475083A1 ES475083A ES475083A ES475083A1 ES 475083 A1 ES475083 A1 ES 475083A1 ES 475083 A ES475083 A ES 475083A ES 475083 A ES475083 A ES 475083A ES 475083 A1 ES475083 A1 ES 475083A1
- Authority
- ES
- Spain
- Prior art keywords
- cpds
- amino
- analgesic
- substd
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title 1
- YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical compound OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- -1 2-phenylpropionic acid ester Chemical class 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la preparación de ésteres de aminoalcoholes y derivados del ácido 2-fenilpropiónico, que consiste esencialmente en convertir el derivado del ácido 2-fenilpropiónico en halogenuro de acilo, el cual se hace reaccionar con un aminoalcohol para obtener ésteres de fórmula general: *** ver imagen 01 en la que R1 representa un radical arilo 1 alquilo, R2 un átomo de hidrógeno y R3 un radical de cadena lineal o ramificada que contiene uno o más grupos amino o bien un radical arilo que contiene por lo menos un grupo amino y alternativamente, R1 puede representar un átomo de hidrógeno, R2 un radical arilo o alquilo y R3 un radical arilo, los cuales contienen uno o más grupos amino.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES475083A ES475083A1 (es) | 1978-11-15 | 1978-11-15 | Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico. |
| DE19792909642 DE2909642A1 (de) | 1978-11-15 | 1979-03-12 | Verfahren zur herstellung von estern aus aminoalkoholen und derivaten der 2-phenylpropionsaeure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES475083A ES475083A1 (es) | 1978-11-15 | 1978-11-15 | Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475083A1 true ES475083A1 (es) | 1979-05-01 |
Family
ID=8477099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475083A Expired ES475083A1 (es) | 1978-11-15 | 1978-11-15 | Procedimiento para la preparacion de esteres de aminoalcoho-les y derivados del acido 2-fenilpropionico. |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2909642A1 (es) |
| ES (1) | ES475083A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622858A (zh) * | 2006-07-27 | 2015-05-20 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2004447A6 (es) * | 1987-07-06 | 1989-01-01 | Sune Coma Nuria | Procedimiento de obtencion de un nuevo ester del acido 2-(p-isobutilfeni)-propionico |
| WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
| KR20150058566A (ko) * | 2007-06-04 | 2015-05-28 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도 |
| JP5997658B2 (ja) * | 2013-05-08 | 2016-09-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
| JP6153264B2 (ja) * | 2015-01-05 | 2017-06-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
-
1978
- 1978-11-15 ES ES475083A patent/ES475083A1/es not_active Expired
-
1979
- 1979-03-12 DE DE19792909642 patent/DE2909642A1/de not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622858A (zh) * | 2006-07-27 | 2015-05-20 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性酮洛芬及相关化合物的前药 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2909642A1 (de) | 1980-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |