ES475976A1 - Un procedimiento para la preparacion del 2,6-dimetil-4-(3- nitrofenil)-3-metoxicarbonil-1,4-dihidropiridin-5-carboxila-to de 2-(n-bencil-n-metilamino)etilo. - Google Patents
Un procedimiento para la preparacion del 2,6-dimetil-4-(3- nitrofenil)-3-metoxicarbonil-1,4-dihidropiridin-5-carboxila-to de 2-(n-bencil-n-metilamino)etilo.Info
- Publication number
- ES475976A1 ES475976A1 ES475976A ES475976A ES475976A1 ES 475976 A1 ES475976 A1 ES 475976A1 ES 475976 A ES475976 A ES 475976A ES 475976 A ES475976 A ES 475976A ES 475976 A1 ES475976 A1 ES 475976A1
- Authority
- ES
- Spain
- Prior art keywords
- nitrophenyl
- dimethyl
- methylamino
- benzyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000005809 transesterification reaction Methods 0.000 title abstract 2
- 229940124549 vasodilator Drugs 0.000 title abstract 2
- 239000003071 vasodilator agent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-(N-benzyl-N-methylamino)-ethyl Chemical group 0.000 abstract 1
- WOUANPHGFPAJCA-UHFFFAOYSA-N 2-[benzyl(methyl)amino]ethanol Chemical compound OCCN(C)CC1=CC=CC=C1 WOUANPHGFPAJCA-UHFFFAOYSA-N 0.000 abstract 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 abstract 1
- 229960000876 cinnarizine Drugs 0.000 abstract 1
- MCTRZKAKODSRLQ-UHFFFAOYSA-N dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC([N+]([O-])=O)=C1 MCTRZKAKODSRLQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960001789 papaverine Drugs 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la preparación del 2,6-di-metil-4-(3-nitrofenil)-3-metoxicarbonil-1,4-dihidropiridin-5-carboxilato de 2-(N-bencil-N-metilamino)etilo (I) de fórmula: ***1 (Ver fórmula)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25791/78A IT1097538B (it) | 1978-07-17 | 1978-07-17 | Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475976A1 true ES475976A1 (es) | 1979-04-16 |
Family
ID=11217752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475976A Expired ES475976A1 (es) | 1978-07-17 | 1978-12-13 | Un procedimiento para la preparacion del 2,6-dimetil-4-(3- nitrofenil)-3-metoxicarbonil-1,4-dihidropiridin-5-carboxila-to de 2-(n-bencil-n-metilamino)etilo. |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR218549A1 (es) |
| BE (1) | BE877311A (es) |
| DE (1) | DE2928022C2 (es) |
| ES (1) | ES475976A1 (es) |
| FR (1) | FR2431488A1 (es) |
| IT (1) | IT1097538B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH655110A5 (de) * | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| JPS61212561A (ja) * | 1985-03-16 | 1986-09-20 | Toyo Pharma- Kk | １，４−ジヒドロピリジン誘導体の製造方法 |
| ES2332168B1 (es) * | 2008-04-30 | 2010-10-27 | Consejo Superior De Investigaciones Cientificas (Csic) (75%) | Forma pseudopolimorfica de hidrocloruro de nicardipina, procedimiento para su preparacion y formulacion que la contiene. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1430961A (en) * | 1972-01-22 | 1976-04-07 | Yamanouchi Pharma Co Ltd | 1-substituted-1,4-dihyddrypyridine derivatives |
| FR2218107A1 (en) * | 1973-02-20 | 1974-09-13 | Yamanouchi Pharma Co Ltd | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents |
| GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
| JPS5611702B2 (es) * | 1974-01-21 | 1981-03-16 | ||
| JPS5720952B2 (es) * | 1974-04-10 | 1982-05-04 |
-
1978
- 1978-07-17 IT IT25791/78A patent/IT1097538B/it active
- 1978-12-13 ES ES475976A patent/ES475976A1/es not_active Expired
-
1979
- 1979-06-27 BE BE0/195999A patent/BE877311A/xx not_active IP Right Cessation
- 1979-07-05 FR FR7917473A patent/FR2431488A1/fr active Granted
- 1979-07-05 AR AR277193A patent/AR218549A1/es active
- 1979-07-11 DE DE2928022A patent/DE2928022C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE877311A (fr) | 1979-10-15 |
| AR218549A1 (es) | 1980-06-13 |
| IT1097538B (it) | 1985-08-31 |
| DE2928022C2 (de) | 1986-11-27 |
| FR2431488A1 (fr) | 1980-02-15 |
| IT7825791A0 (it) | 1978-07-17 |
| FR2431488B1 (es) | 1983-05-27 |
| DE2928022A1 (de) | 1980-01-31 |
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