ES476427A1 - Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. - Google Patents
Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.Info
- Publication number
- ES476427A1 ES476427A1 ES476427A ES476427A ES476427A1 ES 476427 A1 ES476427 A1 ES 476427A1 ES 476427 A ES476427 A ES 476427A ES 476427 A ES476427 A ES 476427A ES 476427 A1 ES476427 A1 ES 476427A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- alkyl
- propyl
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para preparar tetrahidro- 1,3,5-triazina-2,6-diona, de fórmula **fórmula** dónde R1 es un radical alquilo C1-6; y R2 es un radical alquilo C1-4, un radical cicloalquilo C3-8 o alquenilo C3-6, un radical alquilo C5-10 en donde el átomo de carbono alfa de enlace es secundario, un radical bencilo ó 1-(fenil)etilo ó un radical fenilo portando opcionalmente un sustituyente aromático seleccionado entre átomos de halógeno , radicales alquilo C1-4 y alcoxi C1-4; o en donde R1 es un radical n-propilo o etilo y R2 es un radical n-propilo; o en donde R1 es un radical isopropilo y R2 es un radical n-propilo; o en donde R1 es un radical isopropilo y R2 es un radical 3,3-dimetilbutilo; o una sal farmacéuticamente aceptable de las mismas; caracterizado porque se transpone un compuesto de fórmula** fórmula** bajo la influencia de calor a una temperatura de 60 a 200ºC, tras lo cual cuando se requiera una sal de adición de base farmaceúticamente aceptable, se hace reaccionar un compuesto de fórmula I con una base adecuada..
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7183/77A GB1599518A (en) | 1977-02-21 | 1977-02-21 | 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476427A1 true ES476427A1 (es) | 1979-04-16 |
Family
ID=9828208
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467170A Expired ES467170A1 (es) | 1977-02-21 | 1978-02-21 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas |
| ES476427A Expired ES476427A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
| ES476428A Expired ES476428A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467170A Expired ES467170A1 (es) | 1977-02-21 | 1978-02-21 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476428A Expired ES476428A1 (es) | 1977-02-21 | 1978-12-28 | Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4156002A (es) |
| JP (1) | JPS53105487A (es) |
| AR (1) | AR220120A1 (es) |
| AT (1) | AT358592B (es) |
| AU (1) | AU519803B2 (es) |
| BE (1) | BE864124A (es) |
| CA (1) | CA1117867A (es) |
| CH (1) | CH637646A5 (es) |
| CS (2) | CS208463B2 (es) |
| DD (1) | DD134091A5 (es) |
| DE (1) | DE2807381A1 (es) |
| DK (1) | DK67978A (es) |
| ES (3) | ES467170A1 (es) |
| FI (1) | FI64152C (es) |
| FR (1) | FR2381034A1 (es) |
| GB (1) | GB1599518A (es) |
| GR (1) | GR62157B (es) |
| HU (2) | HU182653B (es) |
| IE (1) | IE46650B1 (es) |
| IL (1) | IL54026A (es) |
| IT (1) | IT1158652B (es) |
| LU (1) | LU79092A1 (es) |
| MW (1) | MW478A1 (es) |
| NL (1) | NL7801921A (es) |
| NO (1) | NO780576L (es) |
| NZ (1) | NZ186406A (es) |
| PL (2) | PL107871B1 (es) |
| PT (1) | PT67668B (es) |
| SE (1) | SE440775B (es) |
| SU (2) | SU890976A3 (es) |
| ZA (1) | ZA78671B (es) |
| ZM (1) | ZM1878A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2962124D1 (en) * | 1978-05-26 | 1982-03-25 | Ici Plc | Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture |
| GB8629567D0 (en) * | 1986-12-10 | 1987-01-21 | Boots Co Plc | Therapeutic agents |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| SG173647A1 (en) * | 2009-02-13 | 2011-10-28 | Shionogi & Co | Novel triazine derivative and pharmaceutical composition containing same |
| US9718790B2 (en) | 2010-08-10 | 2017-08-01 | Shionogi & Co., Ltd. | Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same |
| WO2012020742A1 (ja) | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| TW202302541A (zh) * | 2021-03-17 | 2023-01-16 | 美商翰森生物有限責任公司 | 含氮雜環酮、其製備方法和醫藥用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE347973B (es) * | 1965-07-21 | 1972-08-21 | Takeda Chemical Industries Ltd | |
| US4035365A (en) * | 1973-11-01 | 1977-07-12 | Imperial Chemical Industries Limited | Triazinediones |
| GB1543037A (en) * | 1975-02-05 | 1979-03-28 | Ici Ltd | Selective herbicidal triazine-diones |
| JPS5623425B2 (es) * | 1973-11-09 | 1981-05-30 |
-
1977
- 1977-02-21 GB GB7183/77A patent/GB1599518A/en not_active Expired
-
1978
- 1978-02-02 IE IE217/78A patent/IE46650B1/en unknown
- 1978-02-03 ZA ZA00780671A patent/ZA78671B/xx unknown
- 1978-02-07 NZ NZ186406A patent/NZ186406A/en unknown
- 1978-02-07 CA CA000296415A patent/CA1117867A/en not_active Expired
- 1978-02-08 AU AU33112/78A patent/AU519803B2/en not_active Expired
- 1978-02-09 ZM ZM18/78A patent/ZM1878A1/xx unknown
- 1978-02-12 IL IL54026A patent/IL54026A/xx unknown
- 1978-02-13 US US05/877,391 patent/US4156002A/en not_active Expired - Lifetime
- 1978-02-15 DK DK67978A patent/DK67978A/da not_active Application Discontinuation
- 1978-02-15 HU HU78IE836A patent/HU182653B/hu unknown
- 1978-02-15 HU HU78IE826A patent/HU176980B/hu unknown
- 1978-02-15 PL PL1978204641A patent/PL107871B1/pl unknown
- 1978-02-15 PL PL1978211162A patent/PL109995B1/pl unknown
- 1978-02-16 PT PT67668A patent/PT67668B/pt unknown
- 1978-02-16 GR GR55469A patent/GR62157B/el unknown
- 1978-02-17 CS CS781045A patent/CS208463B2/cs unknown
- 1978-02-17 FI FI780529A patent/FI64152C/fi not_active IP Right Cessation
- 1978-02-20 FR FR7804760A patent/FR2381034A1/fr active Granted
- 1978-02-20 NO NO780576A patent/NO780576L/no unknown
- 1978-02-20 BE BE185309A patent/BE864124A/xx not_active IP Right Cessation
- 1978-02-20 SU SU782587045A patent/SU890976A3/ru active
- 1978-02-20 LU LU79092A patent/LU79092A1/xx unknown
- 1978-02-20 SE SE7801930A patent/SE440775B/sv not_active IP Right Cessation
- 1978-02-21 DE DE19782807381 patent/DE2807381A1/de not_active Ceased
- 1978-02-21 JP JP1898978A patent/JPS53105487A/ja active Pending
- 1978-02-21 DD DD78203776A patent/DD134091A5/xx unknown
- 1978-02-21 AT AT127178A patent/AT358592B/de not_active IP Right Cessation
- 1978-02-21 NL NL7801921A patent/NL7801921A/xx not_active Application Discontinuation
- 1978-02-21 AR AR271164A patent/AR220120A1/es active
- 1978-02-21 MW MW4/78A patent/MW478A1/xx unknown
- 1978-02-21 CH CH186378A patent/CH637646A5/de not_active IP Right Cessation
- 1978-02-21 ES ES467170A patent/ES467170A1/es not_active Expired
- 1978-02-21 IT IT20500/78A patent/IT1158652B/it active
- 1978-12-28 ES ES476427A patent/ES476427A1/es not_active Expired
- 1978-12-28 ES ES476428A patent/ES476428A1/es not_active Expired
-
1979
- 1979-02-13 SU SU792723300A patent/SU867303A3/ru active
-
1980
- 1980-05-22 CS CS803610A patent/CS208464B2/cs unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |