ES476428A1 - Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. - Google Patents

Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.

Info

Publication number
ES476428A1
ES476428A1 ES476428A ES476428A ES476428A1 ES 476428 A1 ES476428 A1 ES 476428A1 ES 476428 A ES476428 A ES 476428A ES 476428 A ES476428 A ES 476428A ES 476428 A1 ES476428 A1 ES 476428A1
Authority
ES
Spain
Prior art keywords
formula
preparing
triazina
dionas
tetrahidro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476428A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES476428A1 publication Critical patent/ES476428A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6-dionas de fórmula **fórmula** , donde R1 es un radical isopropilo o n-propilo; y R2 es un radical pent-2-ilo, pent-3-ilo, hex-3-ilo o ciclohexilo; o una sal de adición de base farmacéuticamente aceptable; caracterizado porque comprende acetilar un compuesto de fórmula: **fórmula** en la que R1 R2 se definen como anteriormente, por reacción con un agente acetilante elegido entre cloruro de acetilo, bromuro de acetilo y anhídrido acético; tras lo cual cuando se requiere una sal de adición de base farmacéuticamente aceptable, se hace reaccionar el compuesto de fórmula I con una base adecuada.
ES476428A 1977-02-21 1978-12-28 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas. Expired ES476428A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7183/77A GB1599518A (en) 1977-02-21 1977-02-21 1,3,5-triazine-2,6-diones and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ES476428A1 true ES476428A1 (es) 1979-05-01

Family

ID=9828208

Family Applications (3)

Application Number Title Priority Date Filing Date
ES467170A Expired ES467170A1 (es) 1977-02-21 1978-02-21 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas
ES476427A Expired ES476427A1 (es) 1977-02-21 1978-12-28 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.
ES476428A Expired ES476428A1 (es) 1977-02-21 1978-12-28 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES467170A Expired ES467170A1 (es) 1977-02-21 1978-02-21 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas
ES476427A Expired ES476427A1 (es) 1977-02-21 1978-12-28 Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.

Country Status (32)

Country Link
US (1) US4156002A (es)
JP (1) JPS53105487A (es)
AR (1) AR220120A1 (es)
AT (1) AT358592B (es)
AU (1) AU519803B2 (es)
BE (1) BE864124A (es)
CA (1) CA1117867A (es)
CH (1) CH637646A5 (es)
CS (2) CS208463B2 (es)
DD (1) DD134091A5 (es)
DE (1) DE2807381A1 (es)
DK (1) DK67978A (es)
ES (3) ES467170A1 (es)
FI (1) FI64152C (es)
FR (1) FR2381034A1 (es)
GB (1) GB1599518A (es)
GR (1) GR62157B (es)
HU (2) HU176980B (es)
IE (1) IE46650B1 (es)
IL (1) IL54026A (es)
IT (1) IT1158652B (es)
LU (1) LU79092A1 (es)
MW (1) MW478A1 (es)
NL (1) NL7801921A (es)
NO (1) NO780576L (es)
NZ (1) NZ186406A (es)
PL (2) PL107871B1 (es)
PT (1) PT67668B (es)
SE (1) SE440775B (es)
SU (2) SU890976A3 (es)
ZA (1) ZA78671B (es)
ZM (1) ZM1878A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005911B1 (en) * 1978-05-26 1982-02-17 Imperial Chemical Industries Plc Analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives, pharmaceutical compositions thereof, and process for their manufacture
GB8629567D0 (en) * 1986-12-10 1987-01-21 Boots Co Plc Therapeutic agents
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
MX2011008362A (es) 2009-02-13 2011-08-24 Shionogi & Co Derivado novedoso de triazina y composicion farmaceutica que comprende el mismo.
DK2604595T3 (en) * 2010-08-10 2016-05-23 Shionogi & Co TRIAZINE DERIVATIVES AND PHARMACEUTICAL RELATIONSHIP CONTAINING THIS AND PROVIDING ANALGETIC ACTIVITY
EP2604260B1 (en) 2010-08-10 2017-05-10 Shionogi&Co., Ltd. Novel heterocyclic derivatives and pharmaceutical composition containing same
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
TW202302541A (zh) * 2021-03-17 2023-01-16 美商翰森生物有限責任公司 含氮雜環酮、其製備方法和醫藥用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK117230B (da) * 1965-07-21 1970-03-31 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 1-phenyl- eller -cyclohexyl-5-(γ-carboxypropyl-, γ-hydroxy-n-butyl-, β-acetylethyl- eller γ-hydroxy-n-butyl)-barbitursyrer eller salte deraf.
GB1543037A (en) * 1975-02-05 1979-03-28 Ici Ltd Selective herbicidal triazine-diones
US4035365A (en) * 1973-11-01 1977-07-12 Imperial Chemical Industries Limited Triazinediones
JPS5623425B2 (es) * 1973-11-09 1981-05-30

Also Published As

Publication number Publication date
AU3311278A (en) 1979-08-16
ES467170A1 (es) 1979-08-16
IE780217L (en) 1978-08-21
DE2807381A1 (de) 1978-08-24
IL54026A (en) 1983-06-15
ATA127178A (de) 1980-02-15
US4156002A (en) 1979-05-22
FR2381034B1 (es) 1980-09-19
DK67978A (da) 1978-08-22
MW478A1 (en) 1980-02-13
PT67668B (en) 1979-09-20
PT67668A (en) 1978-03-01
PL107871B1 (pl) 1980-03-31
CH637646A5 (de) 1983-08-15
IE46650B1 (en) 1983-08-10
AT358592B (de) 1980-09-25
ZA78671B (en) 1978-12-27
GR62157B (en) 1979-03-01
CS208464B2 (en) 1981-09-15
BE864124A (fr) 1978-08-21
FI64152C (fi) 1983-10-10
HU182653B (en) 1984-02-28
IT1158652B (it) 1987-02-25
FI64152B (fi) 1983-06-30
CA1117867A (en) 1982-02-09
AR220120A1 (es) 1980-10-15
PL204641A1 (pl) 1978-12-04
NZ186406A (en) 1984-08-24
GB1599518A (en) 1981-10-07
PL109995B1 (en) 1980-06-30
FR2381034A1 (fr) 1978-09-15
DD134091A5 (de) 1979-02-07
SU867303A3 (ru) 1981-09-23
NL7801921A (nl) 1978-08-23
CS208463B2 (en) 1981-09-15
ES476427A1 (es) 1979-04-16
NO780576L (no) 1978-08-22
ZM1878A1 (en) 1981-06-22
SU890976A3 (ru) 1981-12-15
AU519803B2 (en) 1981-12-24
IT7820500A0 (it) 1978-02-21
JPS53105487A (en) 1978-09-13
SE440775B (sv) 1985-08-19
LU79092A1 (fr) 1979-05-25
SE7801930L (sv) 1978-08-22
HU176980B (hu) 1981-06-28
FI780529A7 (fi) 1978-08-22

Similar Documents

Publication Publication Date Title
ATE85790T1 (de) Verfahren und herstellung von adamantan-1derivaten.
FI864150A0 (fi) Kemiska foereningar.
ES476428A1 (es) Procedimiento para preparar tetrahidro-1,3,5-triazina-2,6- dionas.
PE64996A1 (es) Purin-6-ona bisustituida en 2,9
ES8603497A1 (es) Procedimiento para preparar derivados de cefalosporina
ES8801222A1 (es) Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina
CO4700291A1 (es) Compuestos quimicos
AR247205A1 (es) Procedimiento para la obtencion de compuestos de acidos carboxi-3-alquiloxi-9-oxo-9h-fluoreno o 9h-xanteno alcanoicos y sus sales.
KR920016420A (ko) 치환된 테트라하이드로피리딘의 제조방법
ES2039272T3 (es) Sales opticamente activas a base de un tiazolidin-4-carboxilato sustituido y 3-cloro-2-hidroxipropiltrimetilamonio, su preparacion y empleo.
HUT71513A (en) 2-substituted-(3-chlorophenyl)-3,6-diazahexanoic acid derivatives for producing alkil-trazodone derivatives and process for producing them
ES8801660A1 (es) Un procedimiento para preparar derivados de penem
ES2055089T3 (es) Procedimiento para preparar 4-metilpirazoles.
FR2464937B1 (es)
ES2098370T3 (es) Derivado del acido epoxisuccinamico.
RU95106778A (ru) Применение бензотрихлорида в качестве добавки при термическом разложении дихлорэтана
KR850002477A (ko) 4-(3-알키닐옥시-2-하이드록시-프로필)-피퍼라진-1-일-n-페닐-아세트아미드 유도체의 제조방법
SE7701834L (sv) 4-hydroxi-2-kinolinon-3-karboxylsyraestrar
DK82583A (da) Furyloxazolyleddikesyrederivater og fremgangsmaader til fremstilling deraf
ES2118845T3 (es) Proceso para la preparacion de trimetilaluminio por reaccion de cloruros de metilaluminio con sodio en reactores de estado solido.
ES2037004T3 (es) Metodo para producir un compuesto relacionado con el antibiotico tan-749.
AU2474488A (en) Photochromatic composition and photochromatic articles which contain it
ES8503660A1 (es) Procedimiento para la produccion de un n-oxido del ester del acido piridilcarboxilico
KR890002011A (ko) 5-할로 게노-6-아미노-니코틴산 할라이드. 이의 제조방법 및 용도
AR245722A1 (es) Procedimiento para preparar un derivado 23-desoxi-27-halo de compuestos ll-f28249 y composicion para controlar insectos de las plantas excluyendo su aplicacion en animales y el hombre.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405