ES476837A1 - Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno. - Google Patents

Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno.

Info

Publication number
ES476837A1
ES476837A1 ES476837A ES476837A ES476837A1 ES 476837 A1 ES476837 A1 ES 476837A1 ES 476837 A ES476837 A ES 476837A ES 476837 A ES476837 A ES 476837A ES 476837 A1 ES476837 A1 ES 476837A1
Authority
ES
Spain
Prior art keywords
antiallergic
nitrogen bridge
compounds
head
head compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476837A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES476837A1 publication Critical patent/ES476837A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la preparación de nuevos compuestos pirimidínicos condensados con cabeza de puente de nitrógeno. Los nuevos compuestos pueden utilizarse en terapia principalmente como composiciones anti alérgicas o antiasmáticas. Es conocido que los derivados pirido (1,2-a) pirimidina poseen valiosas propiedades de influencia sobre el sistema nervioso central, entre las que destacan las analgésica. El represente más favorable de los anteriores compuestos es el analgésico metosulfato de 1,6- dimetil-3-etoxicarbonil-6-metil-4-xo-4H-pirido(1,2-a)-pirimidino (probonR,Rimazolium) [Arzneimittelforschung 22, 815 (1972)]. Los derivados pirido (1,2-a)pirimidina se preparan por cierre del anillo de los adecuados dialquilésteres del ácido (2-piridilaminometilen)- malónico. Otros derivados pirido (1,2-a)pirimidina
ES476837A 1977-12-29 1978-12-29 Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno. Expired ES476837A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1795A HU180439B (en) 1977-12-29 1977-12-29 Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ES476837A1 true ES476837A1 (es) 1979-06-16

Family

ID=10994684

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476837A Expired ES476837A1 (es) 1977-12-29 1978-12-29 Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno.

Country Status (28)

Country Link
US (1) US4260612A (es)
JP (1) JPS54112895A (es)
AR (1) AR221712A1 (es)
AT (1) AT374476B (es)
AU (1) AU520803B2 (es)
BE (1) BE873141A (es)
CA (1) CA1154766A (es)
CH (1) CH641800A5 (es)
CS (1) CS241014B2 (es)
DD (1) DD143910A5 (es)
DE (1) DE2854112A1 (es)
DK (1) DK585478A (es)
ES (1) ES476837A1 (es)
FI (1) FI65620C (es)
FR (1) FR2413390A1 (es)
GB (1) GB2011408B (es)
GR (1) GR67312B (es)
HU (1) HU180439B (es)
IL (1) IL56132A (es)
IT (1) IT7869932A0 (es)
LU (1) LU80659A1 (es)
NL (1) NL7812479A (es)
NO (1) NO150280C (es)
PL (1) PL119517B1 (es)
PT (1) PT68924A (es)
SE (1) SE434056B (es)
SU (1) SU906379A3 (es)
YU (2) YU296378A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178452B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives
HU183330B (en) * 1981-02-13 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new of 2,4,8-triazaphenalenium-salts
US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5252572A (en) * 1988-02-03 1993-10-12 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786056A (en) * 1954-05-03 1957-03-19 Merck & Co Inc Acylamido-hydroxy pteridines and preparation thereof
GB1147759A (en) * 1965-06-17 1969-04-10 Sterling Drug Inc Aromatic derivatives and preparation thereof
DE1670480C2 (de) * 1966-11-02 1983-06-01 Chinoin Gyógyszer és Vegyészeti Termékek Gyára R.T., 1045 Budapest Pyrido[1,2-a]pyrimidinderivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende pharmazeutische Präparate
GB1141249A (en) * 1967-05-25 1969-01-29 Parke Davis & Co New quinazoline compounds and methods for their production
US3642797A (en) * 1968-06-10 1972-02-15 Sterling Drug Inc 4h-pyrido(1 2-a)pyrimidin-4-ones
JPS50149698A (es) * 1974-05-25 1975-11-29
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones

Also Published As

Publication number Publication date
PL212205A1 (es) 1980-02-25
FR2413390A1 (fr) 1979-07-27
PT68924A (en) 1979-01-01
JPS54112895A (en) 1979-09-04
IL56132A0 (en) 1979-03-12
AT374476B (de) 1984-04-25
CS241014B2 (en) 1986-03-13
US4260612A (en) 1981-04-07
SE7813225L (sv) 1979-06-30
LU80659A1 (de) 1979-04-13
AR221712A1 (es) 1981-03-13
PL119517B1 (en) 1982-01-30
GB2011408A (en) 1979-07-11
CS909078A2 (en) 1985-06-13
NO150280B (no) 1984-06-12
CH641800A5 (de) 1984-03-15
DK585478A (da) 1979-06-30
DE2854112A1 (de) 1979-07-12
GR67312B (es) 1981-06-29
IL56132A (en) 1982-02-28
AU4262878A (en) 1981-06-18
NO150280C (no) 1984-09-19
GB2011408B (en) 1982-06-30
FR2413390B1 (es) 1982-06-11
CA1154766A (en) 1983-10-04
NO784392L (no) 1979-07-02
FI65620C (fi) 1984-06-11
NL7812479A (nl) 1979-07-03
DD143910A5 (de) 1980-09-17
IT7869932A0 (it) 1978-12-22
YU278082A (en) 1983-10-31
YU296378A (en) 1983-10-31
AU520803B2 (en) 1982-02-25
HU180439B (en) 1983-03-28
FI65620B (fi) 1984-02-29
SU906379A3 (ru) 1982-02-15
SE434056B (sv) 1984-07-02
BE873141A (fr) 1979-04-17
ATA901078A (de) 1983-09-15
FI784014A7 (fi) 1979-06-30

Similar Documents

Publication Publication Date Title
IE781878L (en) Imidazole derivatives
ES8801277A1 (es) Procedimiento para preparar (1,2,4) triazolo (1,5-c) quinazolinas
ES8102561A1 (es) Procedimiento de preparacion de los aril-1 arilsulfonil-4 a amino-propoxi-3 1h pirazoles
ES481745A1 (es) Procedimiento de fabricar derivados pirimidinicos con cabe- za de puente de nitrogeno.
NO163331C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 6,7-disubstituerte 1-cyklopropyl-1,4-dihydro-4-okso-1,8-naftyridin-3-karboksylsyrer.
ES8704491A1 (es) Procedimiento para la obtencion de nuevas piridopirimidinas
ES477785A1 (es) Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas.
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
ES476837A1 (es) Procedimientos de preparar derivados pirimidinicos condensa-dos con cabeza de puente de nitrogeno.
DK330378A (da) Fremgangsmaade til fremstilling af terapeutisk aktive 6,7-dihydro-5h, 13h-chinazolino (3,2-a)-(1,4) benzodiazepin-5,13-dioner
NO153137C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte pyrido(1,2-a)pyrimidiner.
ES462755A1 (es) Procedimiento para la preparacion de esteres bencilicos del acido 2-isopropil-4-fenil-3-butenico.
NO871575L (no) Fremgangsmaate for fremstilling av 1,5-benztiazepin-derivater.
ES8706138A1 (es) Procedimiento para la obtencion de nuevas benzoilureas
ES482280A1 (es) Un procedimiento para la preparacion de nuevos derivados 2- (1h-imidazol-1-il)etoxi de pirazolo-3,4-b-piridina-5-metano-les.
PH24207A (en) 2-acylamino-6-amino-4,5,6,7-tetrahydrobenzothiazoles
IE791930L (en) Cyclohexadienes.
ES8605247A1 (es) Procedimiento para la obtencion de arisulfonilguanidinas sustituidas
DE3268605D1 (en) 3,7a-diazacyclohepta(j,k)fluorene derivatives, their preparation and therapeutical use
ES8703847A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinopirimidina
JPS6485998A (en) Acylated splenopentine, manufacture and use
ES8703855A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinotriazina
ES480379A1 (es) Procedimiento para preparar un nuevo n-metilcarbamato n-car-boxilado.
NO903585L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
IE780829L (en) (3,4-dichlorophenylsulphinyl)-acetamideoxime and its¹addition salts, cns therapeutic.