DK330378A - Fremgangsmaade til fremstilling af terapeutisk aktive 6,7-dihydro-5h, 13h-chinazolino (3,2-a)-(1,4) benzodiazepin-5,13-dioner - Google Patents

Fremgangsmaade til fremstilling af terapeutisk aktive 6,7-dihydro-5h, 13h-chinazolino (3,2-a)-(1,4) benzodiazepin-5,13-dioner

Info

Publication number
DK330378A
DK330378A DK330378A DK330378A DK330378A DK 330378 A DK330378 A DK 330378A DK 330378 A DK330378 A DK 330378A DK 330378 A DK330378 A DK 330378A DK 330378 A DK330378 A DK 330378A
Authority
DK
Denmark
Prior art keywords
chinazolino
dioner
benzodiazepine
dihydro
procedure
Prior art date
Application number
DK330378A
Other languages
English (en)
Inventor
K H Mayer
H Heitzer
F Hoffmeister
A Heise
S Kazda
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772733681 external-priority patent/DE2733681A1/de
Priority claimed from DE19772758875 external-priority patent/DE2758875A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK330378A publication Critical patent/DK330378A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK330378A 1977-07-26 1978-07-25 Fremgangsmaade til fremstilling af terapeutisk aktive 6,7-dihydro-5h, 13h-chinazolino (3,2-a)-(1,4) benzodiazepin-5,13-dioner DK330378A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772733681 DE2733681A1 (de) 1977-07-26 1977-07-26 6,7-dihydro-5h, 13h-chinazolino eckige klammer auf 3,2-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-5,13-dione, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE19772758875 DE2758875A1 (de) 1977-12-30 1977-12-30 6,7-dihydro-5h,13h-chinazolino eckige klammer auf 3,2-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-5,13-dione, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK330378A true DK330378A (da) 1979-01-27

Family

ID=25772398

Family Applications (1)

Application Number Title Priority Date Filing Date
DK330378A DK330378A (da) 1977-07-26 1978-07-25 Fremgangsmaade til fremstilling af terapeutisk aktive 6,7-dihydro-5h, 13h-chinazolino (3,2-a)-(1,4) benzodiazepin-5,13-dioner

Country Status (9)

Country Link
US (1) US4187306A (da)
EP (1) EP0000538A1 (da)
JP (1) JPS5424896A (da)
AU (1) AU3828478A (da)
DK (1) DK330378A (da)
ES (1) ES471985A1 (da)
FI (1) FI782318A7 (da)
IL (1) IL55207A0 (da)
IT (1) IT7826042A0 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530790A (en) * 1982-12-27 1985-07-23 Merck & Co., Inc. Cholecystokinin antagonists
US4563451A (en) * 1985-01-25 1986-01-07 Merck & Co., Inc. Quinazolino-1,4-benzodiazepin-5,13-diones
US4559338A (en) * 1985-01-25 1985-12-17 Merck & Co., Inc. Soluble quinazolino-1,4-benzodiazepin-5,13-dione derivatives
US4554272A (en) * 1985-01-25 1985-11-19 Merck & Co., Inc. Substituted quinazolino-1,4-benzodiazepin-6,9-diones and their preparation
US4735941A (en) * 1986-12-23 1988-04-05 Merck & Co., Inc. 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
EP0272868A1 (en) * 1986-12-23 1988-06-29 Merck & Co. Inc. 1,4-Benzodiazepines with 6-membered heterocyclic rings
US5670640A (en) * 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
TWI707859B (zh) * 2017-09-07 2020-10-21 日商衛材R&D企管股份有限公司 五環化合物
MX2021009685A (es) * 2019-03-05 2021-09-10 Eisai R&D Man Co Ltd Compuesto heterociclo pentaciclico.
TWI870286B (zh) * 2019-03-05 2025-01-11 日商衛材R&D企管股份有限公司 五環化合物之鹽及其等之結晶

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280117A (en) * 1964-04-20 1966-10-18 Sandoz Ag Tricyclic quinazolinones
US3651046A (en) * 1969-01-30 1972-03-21 Hoffmann La Roche Quinazolino-benzodiazepines and methods for the preparation thereof

Also Published As

Publication number Publication date
FI782318A7 (fi) 1979-01-27
JPS5424896A (en) 1979-02-24
US4187306A (en) 1980-02-05
EP0000538A1 (de) 1979-02-07
IT7826042A0 (it) 1978-07-24
AU3828478A (en) 1980-01-31
ES471985A1 (es) 1979-10-01
IL55207A0 (en) 1978-09-29

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