ES476955A1 - Un procedimiento para la preparacion de derivados se imida- zoquinazolina. - Google Patents

Un procedimiento para la preparacion de derivados se imida- zoquinazolina.

Info

Publication number
ES476955A1
ES476955A1 ES476955A ES476955A ES476955A1 ES 476955 A1 ES476955 A1 ES 476955A1 ES 476955 A ES476955 A ES 476955A ES 476955 A ES476955 A ES 476955A ES 476955 A1 ES476955 A1 ES 476955A1
Authority
ES
Spain
Prior art keywords
preparation
derivatives
zoquinazoline
imida
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476955A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES476955A1 publication Critical patent/ES476955A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de derivados de imidazoquinazolina de la fórmula general.
ES476955A 1977-07-25 1979-01-18 Un procedimiento para la preparacion de derivados se imida- zoquinazolina. Expired ES476955A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (1)

Publication Number Publication Date
ES476955A1 true ES476955A1 (es) 1979-10-16

Family

ID=25698353

Family Applications (2)

Application Number Title Priority Date Filing Date
ES471981A Expired ES471981A1 (es) 1977-07-25 1978-07-24 Un procedimiento para la preparacion de derivados de imida- zoquinazolina
ES476955A Expired ES476955A1 (es) 1977-07-25 1979-01-18 Un procedimiento para la preparacion de derivados se imida- zoquinazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES471981A Expired ES471981A1 (es) 1977-07-25 1978-07-24 Un procedimiento para la preparacion de derivados de imida- zoquinazolina

Country Status (29)

Country Link
US (1) US4256748A (es)
EP (1) EP0000718B1 (es)
JP (1) JPS5441894A (es)
AR (1) AR218500A1 (es)
AT (1) AT363479B (es)
AU (1) AU519688B2 (es)
BR (1) BR7804763A (es)
CA (1) CA1094555A (es)
CS (1) CS203014B2 (es)
DE (2) DE2832138A1 (es)
DK (1) DK144128C (es)
ES (2) ES471981A1 (es)
FI (1) FI63409C (es)
FR (1) FR2398748A1 (es)
GB (1) GB2001638B (es)
GR (1) GR72968B (es)
HU (1) HU177643B (es)
IE (1) IE47280B1 (es)
IL (1) IL55183A (es)
IT (1) IT1097337B (es)
MC (1) MC1199A1 (es)
MY (1) MY8500249A (es)
NL (1) NL7807507A (es)
NO (1) NO150800C (es)
NZ (1) NZ187921A (es)
PH (1) PH14642A (es)
PT (1) PT68342A (es)
SE (1) SE7808111L (es)
YU (1) YU177578A (es)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
CA1131631A (en) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
EP0029559A3 (en) * 1979-11-24 1981-09-30 Sandoz Ag 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (de) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung eines Imidazochinazolinonderivates
JPS57178234U (es) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
NO164654C (no) * 1984-02-15 1990-10-31 Syntex Inc Analogifremgangsmaate for fremstilling av terapeutisk aktive (2-okso-1,2,3,5-tetrahydroimidazo (2,1-b)kinazolinyl)-oksylakylamider.
GB8514207D0 (en) * 1985-06-05 1985-07-10 Pfizer Ltd Cardiac stimulants
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
JPH06509576A (ja) * 1991-07-29 1994-10-27 ワーナー−ランバート・コンパニー アセチルコリンエステラーゼ阻害剤としてのキナゾリン誘導体
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
AU7604400A (en) * 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
AU2004206783B2 (en) * 2003-01-23 2009-03-26 Shire Holdings Ag Formulation and methods for the treatment of thrombocythemia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
EP3492106B1 (en) 2013-08-09 2021-02-17 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
EP4201403A1 (en) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445430A1 (de) 1962-10-26 1969-01-23 American Home Prod Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen
GB1037375A (en) * 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
AR218500A1 (es) 1980-06-13
GB2001638A (en) 1979-02-07
MY8500249A (en) 1985-12-31
ATA535178A (de) 1981-01-15
FI63409B (fi) 1983-02-28
DK144128B (da) 1981-12-14
IL55183A (en) 1981-11-30
JPS5441894A (en) 1979-04-03
AU519688B2 (en) 1981-12-17
CS203014B2 (en) 1981-02-27
FR2398748A1 (fr) 1979-02-23
US4256748A (en) 1981-03-17
AT363479B (de) 1981-08-10
DK144128C (da) 1982-05-17
GB2001638B (en) 1982-02-10
CA1094555A (en) 1981-01-27
DE2861688D1 (en) 1982-04-29
NO150800C (no) 1984-12-27
FR2398748B1 (es) 1981-09-04
PT68342A (en) 1978-08-01
NL7807507A (nl) 1979-01-29
IT7826019A0 (it) 1978-07-24
ES471981A1 (es) 1979-10-16
BR7804763A (pt) 1979-04-10
HU177643B (en) 1981-11-28
FI63409C (fi) 1983-06-10
NO150800B (no) 1984-09-10
DK328978A (da) 1979-01-26
EP0000718A3 (en) 1979-06-13
YU177578A (en) 1983-01-21
IE781478L (en) 1979-01-25
IL55183A0 (en) 1978-09-29
DE2832138A1 (de) 1979-02-08
IE47280B1 (en) 1984-02-08
EP0000718A2 (de) 1979-02-21
IT1097337B (it) 1985-08-31
FI782248A7 (fi) 1979-01-26
NZ187921A (en) 1981-03-16
AU3812778A (en) 1980-01-24
PH14642A (en) 1981-10-12
MC1199A1 (fr) 1979-03-19
EP0000718B1 (de) 1982-03-24
GR72968B (es) 1984-01-20
NO782541L (no) 1979-01-26
SE7808111L (sv) 1979-01-26

Similar Documents

Publication Publication Date Title
ES476955A1 (es) Un procedimiento para la preparacion de derivados se imida- zoquinazolina.
AR218326A1 (es) Un procedimiento para la fabricacion de derivados de 1,1,2-trifenilalqueno
AR222796A1 (es) Un procedimiento para la preparacion de compuestos 2-fenil-3-benzoil-benzotiofeno
IT1107496B (it) Procedimento per la produzione di chinazoline sostituite mediante ciclizzazione di cianocarbossamidine
ES478200A1 (es) Un procedimiento para la preparacion de ftalazinas.
AR230270A1 (es) Procedimiento para preparar nuevos derivados de 2-alquiltio-3(-alcanoil alcoxicarbonil)-5-halogeno-6-fenoxi-bencimidazol substituidos
BG31945A3 (bg) Метод за получаване на 4-ациламино-фенил-етаноламини
MX148042A (es) Procedimiento mejorado para la produccion de urea-amoniaco
AR221251A1 (es) Un procedimiento para la preparacion de derivados de 4-piperidino-6,7-dialcoxi-quinazolina
IT7827903A0 (it) Procedimento per la produzione dicomposti eterociclici.
ES480112A1 (es) Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
ES462173A1 (es) Procedimiento para la preparacion de derivados de acido 7-a-cilamino-8-oxo-3-oxa-1-azabiciclo-(4,2,0)-octan-2-carboxili-co.
AR222792A1 (es) Un procedimiento de preparacion de derivados de la tienopiridina
RO76721A (ro) Procedeu pentru prepararea 3.12.-hidroxi-4-fenil-cicloalcanonei
AR218296A1 (es) Procedimiento para la preparacion de nuevos derivados de 14-beta-amino-morfina
AR224734A1 (es) Procedimiento para la obtencion de nuevos derivados de disulfuro de bis-(5-halogen-6-sustituido-fenoxi)-2-bencimidazolilo)
ES465896A1 (es) Procedimiento para la preparacion de nuevas ditienilalcohi- laminas.
AR223465A1 (es) Procedimiento para obtener derivados de 5-bencil-2,4-diamino-pirimidinas
IT1099068B (it) Procedimento per la produzione di poliisobuteni
TR19681A (tr) 2,1,3-tiadizain-4-on-2,2 sioksit tuerevlerinin ueretilmesini mahsus usul
ES462849A1 (es) Un procedimiento para la preparacion de nuevos derivados de 3,5-diona-4,4-dimetil-pirrolidina.
RO76088A (ro) Procedeu pentru prepararea de tiocarbamati
OA05675A (fr) Procédé de préparation de dérivés de méthylamine.
IT7851891A0 (it) Procedimento per la produzione di ammino-idrossi-composti aromatici
MX5454E (es) Procedimiento para preparar derivados de la 1,2,4-triazin-5-ona

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201