ES477217A1 - A PROCEDURE FOR THE PREPARATION OF A LIPOSOMIC FOOD CARRIER SYSTEM. - Google Patents

A PROCEDURE FOR THE PREPARATION OF A LIPOSOMIC FOOD CARRIER SYSTEM.

Info

Publication number
ES477217A1
ES477217A1 ES477217A ES477217A ES477217A1 ES 477217 A1 ES477217 A1 ES 477217A1 ES 477217 A ES477217 A ES 477217A ES 477217 A ES477217 A ES 477217A ES 477217 A1 ES477217 A1 ES 477217A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
carrier system
sterol
liposomic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477217A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES477217A1 publication Critical patent/ES477217A1/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de un sistema portador de medicamentos liposómico, donde un medicamente se encapsula dentro de liposomas constituido por un esterol y un lípido alifático capaz de formar micelas en agua, cuyo procedimiento comprende: a) poner en contacto los cristales sólidos de esterol con una solución micelar acuosa del lípido alifático y del medicamento a una temperatura de hasta 60ºC, en atmósfera inerte, durante un tiempo comprendido entre 2 y 60 minutos, para permitir la penetración de los cristales de esterol por las micelas; y b) someter a irradiación ultrasónica los cristales líquidos procedentes de la etapa anterior, para convertirlos en liposomas.Procedure for the preparation of a liposomal drug carrier system, where a drug is encapsulated within liposomes made up of a sterol and an aliphatic lipid capable of forming micelles in water, which procedure comprises: a) contacting the solid crystals of sterol with an aqueous micellar solution of the aliphatic lipid and the drug at a temperature of up to 60ºC, in an inert atmosphere, for a time between 2 and 60 minutes, to allow the penetration of the sterol crystals through the micelles; and b) subjecting the liquid crystals from the previous stage to ultrasonic irradiation, to convert them into liposomes.

ES477217A 1978-01-27 1979-01-26 A PROCEDURE FOR THE PREPARATION OF A LIPOSOMIC FOOD CARRIER SYSTEM. Expired ES477217A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87283578A 1978-01-27 1978-01-27

Publications (1)

Publication Number Publication Date
ES477217A1 true ES477217A1 (en) 1980-04-01

Family

ID=25360392

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477217A Expired ES477217A1 (en) 1978-01-27 1979-01-26 A PROCEDURE FOR THE PREPARATION OF A LIPOSOMIC FOOD CARRIER SYSTEM.

Country Status (19)

Country Link
JP (1) JPS54113417A (en)
AT (1) AT368888B (en)
AU (1) AU524529B2 (en)
BE (1) BE873715A (en)
CA (1) CA1111347A (en)
DE (1) DE2902672A1 (en)
DK (1) DK22879A (en)
ES (1) ES477217A1 (en)
FI (1) FI790164A7 (en)
FR (1) FR2415460A1 (en)
GB (1) GB2013087B (en)
IE (1) IE790144L (en)
IL (1) IL56499A (en)
IT (1) IT1109867B (en)
NL (1) NL7900545A (en)
NZ (1) NZ189477A (en)
PT (1) PT69132A (en)
SE (1) SE7900458L (en)
ZA (1) ZA79349B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2026340B (en) * 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
JPS5874619A (en) * 1981-10-29 1983-05-06 Nippon Shinyaku Co Ltd Liposome and its preparation
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
EP0102324A3 (en) * 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipids and surfactants in an aqueous medium
DE3421468A1 (en) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim LIPID NANOPELLETS AS A CARRIER SYSTEM FOR MEDICINAL PRODUCTS FOR PERORAL USE
US4849227A (en) * 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
US5077211A (en) * 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
WO1992003123A1 (en) * 1990-08-28 1992-03-05 Liposome Technology, Inc. Liposome alternative bilayer formulations
FR2714621B1 (en) * 1994-01-06 1996-02-23 Centre Nat Rech Scient Process for the preparation of liposomes without using an organic solvent.
CA2347094C (en) 1999-08-13 2015-02-03 Suntory Limited Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms
JP4088097B2 (en) 2002-04-26 2008-05-21 サントリー株式会社 Method for producing highly unsaturated fatty acid-containing lipid
AU2013203682B2 (en) * 2011-08-25 2016-03-31 Trophos Liposome comprising at least one cholesterol derivative
FR2979239A1 (en) * 2011-08-25 2013-03-01 Trophos LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE
CN113967192A (en) * 2021-11-09 2022-01-25 陕西海斯夫生物工程有限公司 Pharmaceutical composition for accelerating wound healing, preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957951A (en) * 1974-08-23 1976-05-18 International Telephone And Telegraph Corporation Process for removing contaminants from hot waste gas streams
FR2408387A2 (en) * 1975-06-30 1979-06-08 Oreal COMPOSITIONS BASED ON AQUEOUS DISPERSIONS OF LIPID SPHERULES
FR2315991A1 (en) * 1975-06-30 1977-01-28 Oreal METHOD OF MANUFACTURING AQUEOUS DISPERSIONS OF LIPID SPHERULES AND CORRESPONDING NEW COMPOSITIONS
FR2374910A1 (en) * 1976-10-23 1978-07-21 Choay Sa PREPARATION BASED ON HEPARIN, INCLUDING LIPOSOMES, PROCESS FOR OBTAINING IT AND MEDICINAL PRODUCTS CONTAINING SUCH PREPARATIONS

Also Published As

Publication number Publication date
IL56499A0 (en) 1979-03-12
JPS54113417A (en) 1979-09-05
IT1109867B (en) 1985-12-23
FR2415460B1 (en) 1983-05-20
GB2013087A (en) 1979-08-08
ZA79349B (en) 1980-09-24
SE7900458L (en) 1979-07-28
DE2902672A1 (en) 1979-08-02
AU524529B2 (en) 1982-09-23
AT368888B (en) 1982-11-25
GB2013087B (en) 1982-07-21
IL56499A (en) 1981-09-13
IE790144L (en) 1979-07-27
NZ189477A (en) 1981-05-01
AU4367879A (en) 1979-08-02
PT69132A (en) 1979-02-01
CA1111347A (en) 1981-10-27
FR2415460A1 (en) 1979-08-24
ATA58979A (en) 1982-04-15
IT7919649A0 (en) 1979-01-26
BE873715A (en) 1979-07-25
DK22879A (en) 1979-07-28
FI790164A7 (en) 1979-07-28
NL7900545A (en) 1979-07-31

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