ES478430A1 - Procedimiento para preparar derivados de isoquinolina. - Google Patents

Procedimiento para preparar derivados de isoquinolina.

Info

Publication number
ES478430A1
ES478430A1 ES478430A ES478430A ES478430A1 ES 478430 A1 ES478430 A1 ES 478430A1 ES 478430 A ES478430 A ES 478430A ES 478430 A ES478430 A ES 478430A ES 478430 A1 ES478430 A1 ES 478430A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkoxy
formula
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478430A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH264378A external-priority patent/CH636859A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES478430A1 publication Critical patent/ES478430A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedimiento para preparar derivados de isoquinolina, de fórmula I **(Fórmula)** en donde R1, R2 y R3 se seleccionan de los significados siguientes (i), (ii) y (iii):- (i) R1 y R2, independientemente, son hidrógeno, alquilo (C1- 6),trifluometilo, halógeno, o alcoxi (C1-4), y R3 es hidrógeno, o (ii) (a) R1 y R2, independientemente, son hidrógeno, alquilo (C1-6), trifluometilo o halógeno, o (b) R1 es alcoxi (C1-4) y R2 es alquilo (C1-6), trifluometilo, halógeno o alcoxi (C1-4), y R3 es alquilo (C1-6), un radical de fórmula II, -CH2.CH=CR4R5 II
ES478430A 1978-03-10 1979-03-08 Procedimiento para preparar derivados de isoquinolina. Expired ES478430A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH264378A CH636859A5 (en) 1978-03-10 1978-03-10 Substituted cis-4a-phenyldecahydroisoquinolines, their preparation and drugs containing them
CH628378 1978-06-08

Publications (1)

Publication Number Publication Date
ES478430A1 true ES478430A1 (es) 1979-05-16

Family

ID=25691019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478430A Expired ES478430A1 (es) 1978-03-10 1979-03-08 Procedimiento para preparar derivados de isoquinolina.

Country Status (15)

Country Link
JP (1) JPS54128585A (es)
AU (1) AU529350B2 (es)
CA (1) CA1118775A (es)
DE (1) DE2907461A1 (es)
DK (1) DK88279A (es)
ES (1) ES478430A1 (es)
FI (1) FI790701A7 (es)
FR (1) FR2419286A2 (es)
GB (1) GB2016012B (es)
IL (1) IL56823A0 (es)
IT (1) IT7948220A0 (es)
NL (1) NL7901764A (es)
NZ (1) NZ189856A (es)
PH (1) PH14162A (es)
SE (1) SE7901848L (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600649B1 (fr) * 1986-06-26 1989-02-24 Rhone Poulenc Sante Procede de preparation du maleate acide de levomepromazine
DE69602248T4 (de) * 1995-07-20 2000-10-26 Toray Industries, Inc. 4a-aryldecahydroisochinolin-verbindungen und ihre medizinische verwendungen
CN105473554B (zh) * 2013-07-10 2019-08-13 沃泰克斯药物股份有限公司 作为离子通道调节剂的稠合的哌啶酰胺类

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655150A1 (de) * 1975-12-16 1977-06-23 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung

Also Published As

Publication number Publication date
NL7901764A (nl) 1979-09-12
JPS54128585A (en) 1979-10-05
FR2419286B1 (es) 1982-03-05
FI790701A7 (fi) 1979-09-11
DE2907461A1 (de) 1979-09-20
CA1118775A (en) 1982-02-23
AU529350B2 (en) 1983-06-02
DK88279A (da) 1979-09-11
IL56823A0 (en) 1979-05-31
FR2419286A2 (fr) 1979-10-05
AU4495679A (en) 1979-09-13
NZ189856A (en) 1981-12-15
GB2016012B (en) 1982-07-21
IT7948220A0 (it) 1979-03-06
SE7901848L (sv) 1979-09-11
PH14162A (en) 1981-03-19
GB2016012A (en) 1979-09-19

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