ES482075A1 - Procedimiento para la preparacion de carbonilaminofenoxilicosustituidos con biciclo -3.1.0-hexilo. - Google Patents

Procedimiento para la preparacion de carbonilaminofenoxilicosustituidos con biciclo -3.1.0-hexilo.

Info

Publication number
ES482075A1
ES482075A1 ES482075A ES482075A ES482075A1 ES 482075 A1 ES482075 A1 ES 482075A1 ES 482075 A ES482075 A ES 482075A ES 482075 A ES482075 A ES 482075A ES 482075 A1 ES482075 A1 ES 482075A1
Authority
ES
Spain
Prior art keywords
preparation
hexyl
procedure
endobicyclo
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482075A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES482075A1 publication Critical patent/ES482075A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/136—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de carbonilaminofenoxílicos sustituidos con biciclo [3.1.0]HEXILO. Este invento se refiere a un procedimiento para la preparación de 1-alcohilamino-3-(4- [endobiciclo[3.1.0]hex-6-il)alcohilureido]-1-fenoxi)-2- propanol y a sus sales farmacéuticamente aceptables; de 1- alcohilamino-3-(4-[endobiciclo[3.1.0]hex-6- il)alcohilcarbonilamino]-1-fenoxi)-2-propanol y a sus sales farmacéuticamente aceptables. Este invento se refiere además a un procedimiento para la preparación de 5-(4/[endobiciclo[3.1.0]hex-6- il)alcohilureido]-metil-3-alcohil-oxazolidinas opcionalmente sustituidas en posición 2 y a sus sales farmacéuticamente aceptables; de 5-(4-/[endobiciclo[3.1.0]nex-6- il)alcohilcarbnilamino]-1-fenoxi)-metil-3-alcohil-oxazolidinas opcionalmente sustituidas en posición 2 y a sus sales farmacéuticamente aceptables.
ES482075A 1978-07-03 1979-06-29 Procedimiento para la preparacion de carbonilaminofenoxilicosustituidos con biciclo -3.1.0-hexilo. Expired ES482075A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/921,371 US4177280A (en) 1978-07-03 1978-07-03 Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents

Publications (1)

Publication Number Publication Date
ES482075A1 true ES482075A1 (es) 1980-03-01

Family

ID=25445332

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482075A Expired ES482075A1 (es) 1978-07-03 1979-06-29 Procedimiento para la preparacion de carbonilaminofenoxilicosustituidos con biciclo -3.1.0-hexilo.

Country Status (13)

Country Link
US (1) US4177280A (es)
EP (1) EP0007710A1 (es)
JP (1) JPS559074A (es)
AU (1) AU4852379A (es)
CA (1) CA1105054A (es)
DD (1) DD148215A5 (es)
DK (1) DK276479A (es)
ES (1) ES482075A1 (es)
IL (1) IL57705A0 (es)
NZ (1) NZ190880A (es)
PL (1) PL116994B1 (es)
SU (1) SU854271A3 (es)
ZA (1) ZA793292B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402976A (en) * 1981-04-24 1983-09-06 E. R. Squibb & Sons, Inc. Method for treating glaucoma with systemic nadolol compositions
DE3887544T2 (de) * 1987-03-09 1994-06-01 Procter & Gamble Beta-aminoethyl-substituierte Phenyl-Verbindungen, diese enthaltende entzündungshemmende oder analgetische Zusammensetzungen.
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA3047002A1 (en) * 2017-01-17 2018-07-26 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1078852A (en) * 1964-09-30 1967-08-09 Ici Ltd Alkanolamine derivatives
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
CA1149819A (en) * 1970-01-08 1983-07-12 Max Wilhelm Process for the manufacture of new amines
US4038414A (en) * 1972-06-08 1977-07-26 Ciba-Geigy Corporation Amines and processes for their manufacture
US4035420A (en) * 1972-07-06 1977-07-12 Aktiebolaget Hassle Substituted ureido alkylene phenoxy propanolamines
AT334385B (de) * 1973-12-20 1976-01-10 Chemie Linz Ag Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen
US4063025A (en) * 1975-02-05 1977-12-13 Yamanouchi Pharmaceutical Co., Ltd. 4-Substituted amino-α-aminomethylbenzyl alcohol derivatives
US4064258A (en) * 1976-07-19 1977-12-20 Syntex (U.S.A.) Inc. Thiazole cardiovascular agents

Also Published As

Publication number Publication date
DD148215A5 (de) 1981-05-13
AU4852379A (en) 1980-01-10
IL57705A0 (en) 1979-11-30
DK276479A (da) 1980-01-04
EP0007710A1 (en) 1980-02-06
PL116994B1 (en) 1981-07-31
CA1105054A (en) 1981-07-14
JPS559074A (en) 1980-01-22
PL216661A1 (es) 1980-03-24
SU854271A3 (ru) 1981-08-07
NZ190880A (en) 1981-04-24
ZA793292B (en) 1981-02-25
US4177280A (en) 1979-12-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001