ES482421A1 - Un procedimiento para la preparacion de nuevos derivados de prostaglandina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de prostaglandina.Info
- Publication number
- ES482421A1 ES482421A1 ES482421A ES482421A ES482421A1 ES 482421 A1 ES482421 A1 ES 482421A1 ES 482421 A ES482421 A ES 482421A ES 482421 A ES482421 A ES 482421A ES 482421 A1 ES482421 A1 ES 482421A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- substituent
- hydrogen
- phenyl
- vinylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la preparación de nuevos derivados de prostaglandina, de fórmula I: **(Fórmula-01)** y opcionalmente para la preparación de una sal farmacológicamente aceptable del mismo donde: A es etileno o cis-vinileno; B es etileno o trans-vinileno; Y es hidrógeno o hidroxi; G es CH2Ar, Ch2OAr o CRZ(CH2)3CH3; Ar es fenilo, fluorfenilo, clorofenilo, metilfenilo, etilfenilo, metoxifenilo, etoxifenilo, bifenilo y trifluor metilfenilo; R es hidrógeno o metilo y Z es hidrógeno o metilo; cuyo procedimiento consiste en: hacer reaccionar un intermediario de fórmula (III): **(Fórmula-02)** donde A, B y G son los definidos anteriormente, con un reactivo de grupos salientes para formar un derivado de un grupo ácido carboxílico con un grupo saliente fácilmente desplazable, seguido de desplazamiento del grupo saliente con 5-aminotetrazol; y después hacer reaccionar opcionalmente con una base metálica, una amina, amoniaco o una base amínica cuaternaria farmacológicamente aceptables para formaruna sal farmacológicamente aceptable de un compuesto de fórmula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86956978A | 1978-01-16 | 1978-01-16 | |
| US89373178A | 1978-04-05 | 1978-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES482421A1 true ES482421A1 (es) | 1980-04-01 |
Family
ID=27128123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482421A Expired ES482421A1 (es) | 1978-01-16 | 1979-07-11 | Un procedimiento para la preparacion de nuevos derivados de prostaglandina. |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS54100378A (es) |
| AR (1) | AR222817A1 (es) |
| AT (1) | AT367755B (es) |
| AU (1) | AU507853B2 (es) |
| CA (1) | CA1152502A (es) |
| CH (1) | CH635833A5 (es) |
| DD (1) | DD141155A5 (es) |
| DE (1) | DE2901476C3 (es) |
| DK (1) | DK523378A (es) |
| ES (1) | ES482421A1 (es) |
| FI (1) | FI790120A7 (es) |
| FR (1) | FR2414503A1 (es) |
| GB (1) | GB2012272B (es) |
| GR (1) | GR72747B (es) |
| IE (1) | IE48175B1 (es) |
| IL (1) | IL56433A (es) |
| IN (1) | IN150279B (es) |
| IT (1) | IT1110992B (es) |
| LU (1) | LU80789A1 (es) |
| NL (1) | NL7900292A (es) |
| NO (1) | NO790122L (es) |
| NZ (1) | NZ189377A (es) |
| PH (3) | PH15031A (es) |
| PL (1) | PL117869B1 (es) |
| PT (1) | PT69076A (es) |
| SE (1) | SE427657B (es) |
| SU (1) | SU831071A3 (es) |
| YU (1) | YU4579A (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788209A (fr) * | 1971-09-01 | 1973-02-28 | Pfizer | Derives tetrazoyliques des prostaglandines naturelles |
| DD118856A5 (es) * | 1972-11-08 | 1976-03-20 | ||
| IE43462B1 (en) * | 1975-06-23 | 1981-03-11 | Pfizer | Substituted tetranorprostaglandins |
| DE2559093C3 (de) * | 1975-12-30 | 1981-12-24 | Pfizer Inc., 10017 New York, N.Y. | 2-Desarboxy-2-[tetrazol-5-yl]-11-desoxy-ω-pentanorprostaglandine der E- oder F-Reihe und deren C↓15↓-Epimere |
| US4404372A (en) * | 1977-06-13 | 1983-09-13 | Pfizer Inc. | 15-Substituted-ω-pentanorprostaglandin derivatives |
-
1978
- 1978-11-23 IN IN841/DEL/78A patent/IN150279B/en unknown
- 1978-11-23 DK DK523378A patent/DK523378A/da not_active Application Discontinuation
- 1978-12-27 PL PL1978212183A patent/PL117869B1/pl unknown
- 1978-12-27 SU SU782715902A patent/SU831071A3/ru active
- 1978-12-27 DD DD78210198A patent/DD141155A5/de unknown
-
1979
- 1979-01-11 YU YU00045/79A patent/YU4579A/xx unknown
- 1979-01-12 CA CA000319536A patent/CA1152502A/en not_active Expired
- 1979-01-12 PH PH22056A patent/PH15031A/en unknown
- 1979-01-12 JP JP286979A patent/JPS54100378A/ja active Pending
- 1979-01-15 NZ NZ189377A patent/NZ189377A/xx unknown
- 1979-01-15 LU LU80789A patent/LU80789A1/fr unknown
- 1979-01-15 NO NO790122A patent/NO790122L/no unknown
- 1979-01-15 IE IE60/79A patent/IE48175B1/en unknown
- 1979-01-15 IL IL56433A patent/IL56433A/xx unknown
- 1979-01-15 FI FI790120A patent/FI790120A7/fi unknown
- 1979-01-15 NL NL7900292A patent/NL7900292A/xx not_active Application Discontinuation
- 1979-01-15 GR GR58098A patent/GR72747B/el unknown
- 1979-01-15 IT IT19290/79A patent/IT1110992B/it active
- 1979-01-15 FR FR7900857A patent/FR2414503A1/fr active Granted
- 1979-01-15 AU AU43359/79A patent/AU507853B2/en not_active Ceased
- 1979-01-15 GB GB791428A patent/GB2012272B/en not_active Expired
- 1979-01-15 PT PT69076A patent/PT69076A/pt unknown
- 1979-01-15 CH CH38079A patent/CH635833A5/fr not_active IP Right Cessation
- 1979-01-15 SE SE7900353A patent/SE427657B/sv not_active IP Right Cessation
- 1979-01-15 AT AT0027579A patent/AT367755B/de not_active IP Right Cessation
- 1979-01-16 AR AR275174A patent/AR222817A1/es active
- 1979-01-16 DE DE2901476A patent/DE2901476C3/de not_active Expired
- 1979-07-11 ES ES482421A patent/ES482421A1/es not_active Expired
- 1979-11-19 PH PH23301A patent/PH15643A/en unknown
- 1979-11-19 PH PH23299A patent/PH15653A/en unknown
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