ES482755A1 - Anionic ion exchange resins with cholesterol-decreasing properties - Google Patents
Anionic ion exchange resins with cholesterol-decreasing propertiesInfo
- Publication number
- ES482755A1 ES482755A1 ES482755A ES482755A ES482755A1 ES 482755 A1 ES482755 A1 ES 482755A1 ES 482755 A ES482755 A ES 482755A ES 482755 A ES482755 A ES 482755A ES 482755 A1 ES482755 A1 ES 482755A1
- Authority
- ES
- Spain
- Prior art keywords
- cholesterol
- ion exchange
- exchange resins
- anionic ion
- decreasing properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000129 anionic group Chemical group 0.000 title abstract 2
- 239000003456 ion exchange resin Substances 0.000 title abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 title abstract 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000003431 cross linking reagent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000001451 organic peroxides Chemical class 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
- C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Steroid Compounds (AREA)
Abstract
Anionic ion exchange resins having cholesterol-reducing properties are characterised by an apparent density in water of 0.18 to 0.20 g of dry material/ ml and a water absorption capacity of 69 to 73% by weight. Non-toxic styrene, acrylic or epichlorohydrin resins are suitable but require different degrees of regular cross-linking within critical limits. They can be produced by polymerization at a low rate using organic peroxides as catalysts and divinyl compounds as cross-linking agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2601478A IT1097396B (en) | 1978-07-24 | 1978-07-24 | Hypocholesterolaemic anion exchange resins - comprise slightly crosslinked styrene! acrylic! or epoxy! polymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES482755A1 true ES482755A1 (en) | 1980-04-16 |
Family
ID=11218412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482755A Expired ES482755A1 (en) | 1978-07-24 | 1979-07-23 | Anionic ion exchange resins with cholesterol-decreasing properties |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5521480A (en) |
| AU (1) | AU529979B2 (en) |
| BE (1) | BE877101A (en) |
| CA (1) | CA1141892A (en) |
| DE (1) | DE2924893C2 (en) |
| ES (1) | ES482755A1 (en) |
| FR (1) | FR2432032A1 (en) |
| GB (1) | GB2026501B (en) |
| IT (1) | IT1097396B (en) |
| NL (1) | NL182568C (en) |
| NZ (1) | NZ190878A (en) |
| YU (1) | YU179079A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1213397A (en) * | 1980-10-20 | 1986-10-28 | Judith L. Page | Weight control with alkyl styrene polymers |
| US5230885A (en) * | 1987-12-23 | 1993-07-27 | Smith Kline & French Laboratories Limited | Polystyrene anion exchange polymer pharmaceutical composition |
| GB8730010D0 (en) * | 1987-12-23 | 1988-02-03 | Smith Kline French Lab | Compounds |
| GB8911719D0 (en) * | 1989-05-22 | 1989-07-05 | Smith Kline French Lab | Compounds |
| GB8913700D0 (en) * | 1989-06-14 | 1989-08-02 | Smith Kline French Lab | Compounds |
| GB8913699D0 (en) * | 1989-06-14 | 1989-08-02 | Smith Kline French Lab | Compounds |
| GB8928278D0 (en) * | 1989-12-14 | 1990-02-21 | Smith Kline French Lab | Compounds |
-
1978
- 1978-07-24 IT IT2601478A patent/IT1097396B/en active
-
1979
- 1979-02-14 FR FR7903703A patent/FR2432032A1/en active Granted
- 1979-04-25 GB GB7914457A patent/GB2026501B/en not_active Expired
- 1979-06-19 BE BE0/195841A patent/BE877101A/en not_active IP Right Cessation
- 1979-06-20 DE DE2924893A patent/DE2924893C2/en not_active Expired
- 1979-06-25 AU AU48341/79A patent/AU529979B2/en not_active Ceased
- 1979-06-29 NZ NZ190878A patent/NZ190878A/en unknown
- 1979-07-09 NL NLAANVRAGE7905353,A patent/NL182568C/en not_active IP Right Cessation
- 1979-07-23 CA CA000332338A patent/CA1141892A/en not_active Expired
- 1979-07-23 ES ES482755A patent/ES482755A1/en not_active Expired
- 1979-07-23 JP JP9270379A patent/JPS5521480A/en active Granted
- 1979-07-23 YU YU01790/79A patent/YU179079A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2026501A (en) | 1980-02-06 |
| NL182568C (en) | 1988-04-05 |
| BE877101A (en) | 1979-10-15 |
| DE2924893C2 (en) | 1983-08-04 |
| NZ190878A (en) | 1982-05-31 |
| GB2026501B (en) | 1982-12-08 |
| IT7826014A0 (en) | 1978-07-24 |
| DE2924893A1 (en) | 1980-02-14 |
| CA1141892A (en) | 1983-02-22 |
| IT1097396B (en) | 1985-08-31 |
| JPS5521480A (en) | 1980-02-15 |
| FR2432032B1 (en) | 1983-11-18 |
| YU179079A (en) | 1982-10-31 |
| FR2432032A1 (en) | 1980-02-22 |
| AU529979B2 (en) | 1983-06-30 |
| AU4834179A (en) | 1980-02-07 |
| JPS6218218B2 (en) | 1987-04-22 |
| NL182568B (en) | 1987-11-02 |
| NL7905353A (en) | 1980-01-28 |
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