ES482917A1 - Procedimiento para la preparacion de polialcoxifenilpirroli-donas - Google Patents

Procedimiento para la preparacion de polialcoxifenilpirroli-donas

Info

Publication number
ES482917A1
ES482917A1 ES482917A ES482917A ES482917A1 ES 482917 A1 ES482917 A1 ES 482917A1 ES 482917 A ES482917 A ES 482917A ES 482917 A ES482917 A ES 482917A ES 482917 A1 ES482917 A1 ES 482917A1
Authority
ES
Spain
Prior art keywords
image
alkoxyphenylpyrrolidones
preparation
medicaments containing
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482917A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES482917A1 publication Critical patent/ES482917A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

El procedimiento, conforme al invento, de la condensación de compuestos de la fórmula general II con compuestos de la fórmula III se efectúa conforme a métodos en sí conocidos. Si se parte de compuestos de la fórmula II, en los cuales Y significa cloro, la amina secundaria de la fórmula III es utilizada en un ligero exceso, en presencia de un agente de condensación básico, en un disolvente inerte. Disolventes inertes son, por ejemplo, hidrocarburos alifáticos y aromáticos tales como ligroina, hexano, benceno y tolueno, éteres tales como dietiléter, glicoldimetiléter, tetrahidrofurano y dioxano, alcoholes tales como metanol e isopropanol.
ES482917A 1978-08-01 1979-07-27 Procedimiento para la preparacion de polialcoxifenilpirroli-donas Expired ES482917A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782834114 DE2834114A1 (de) 1978-08-01 1978-08-01 Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ES482917A1 true ES482917A1 (es) 1980-04-16

Family

ID=6046151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482917A Expired ES482917A1 (es) 1978-08-01 1979-07-27 Procedimiento para la preparacion de polialcoxifenilpirroli-donas

Country Status (15)

Country Link
US (1) US4219551A (es)
EP (1) EP0008645B1 (es)
JP (1) JPS5522686A (es)
AT (1) ATE9221T1 (es)
AU (1) AU533442B2 (es)
CA (1) CA1115701A (es)
CS (1) CS225816B2 (es)
DD (1) DD145104B3 (es)
DE (2) DE2834114A1 (es)
DK (1) DK152426C (es)
ES (1) ES482917A1 (es)
HU (1) HU183103B (es)
IE (1) IE48915B1 (es)
IL (1) IL57926A (es)
SU (1) SU878197A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424685A1 (de) * 1984-07-05 1986-02-06 Beiersdorf Ag, 2000 Hamburg Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US4931443A (en) * 1986-10-27 1990-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compound and pharmaceutical use thereof
DE3809031A1 (de) * 1988-03-15 1989-09-28 Schering Ag Neues mittel gegen obstruktive blasenentleerungsstoerung
DE3921593A1 (de) * 1989-06-28 1991-01-10 Schering Ag Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester
KR970702276A (ko) * 1994-04-22 1997-05-13 고오사이 아끼오 에테르 화합물 및 그의 용도(ether compound and use thereof)
DE19648011A1 (de) * 1996-11-20 1998-05-28 Bayer Ag Cyclische Imine
DK1406898T3 (da) * 2001-07-19 2005-05-30 Cv Therapeutics Inc Substituerede piperazinforbindelser og anvendelse af disse som fedtsyreoxidationsinhibitorer
CA2463469A1 (en) * 2001-10-16 2003-04-24 Memory Pharmaceuticals Corporation 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
JP2006523710A (ja) * 2003-04-16 2006-10-19 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ４インヒビター
KR20060005375A (ko) * 2003-04-18 2006-01-17 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제로서의 피라졸 유도체
EP1799673A1 (en) * 2004-10-15 2007-06-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
CN101166737A (zh) * 2004-10-20 2008-04-23 记忆药物公司 磷酸二酯酶4抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577415A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-substituted phenoxypyrrolidines
DE2263211A1 (de) * 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim Neue arylpiperazine und verfahren zu ihrer herstellung
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4120969A (en) * 1975-09-23 1978-10-17 A. H. Robins Company, Incorporated Heterocyclic analgetic and antidiarrheal compounds
DE2737630A1 (de) * 1977-08-20 1979-03-01 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4096331A (en) * 1976-12-28 1978-06-20 A. H. Robins Company, Incorporated 1-Substituted-3-aminoethoxypyrrolidines

Also Published As

Publication number Publication date
DD145104B3 (de) 1990-07-18
IE48915B1 (en) 1985-06-12
HU183103B (en) 1984-04-28
JPH0371423B2 (es) 1991-11-13
EP0008645A1 (de) 1980-03-19
IL57926A0 (en) 1979-11-30
AU4944079A (en) 1980-02-07
JPS5522686A (en) 1980-02-18
IL57926A (en) 1983-10-31
AU533442B2 (en) 1983-11-24
US4219551A (en) 1980-08-26
DK152426C (da) 1988-08-29
DE2834114A1 (de) 1980-02-14
IE791453L (en) 1980-02-01
ATE9221T1 (de) 1984-09-15
CS225816B2 (en) 1984-02-13
DK323179A (da) 1980-02-02
CA1115701A (en) 1982-01-05
EP0008645B1 (de) 1984-09-05
DK152426B (da) 1988-02-29
DD145104A5 (de) 1980-11-19
DE2967204D1 (en) 1984-10-11
SU878197A3 (ru) 1981-10-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203