ES484112A1 - Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina - Google Patents
Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridinaInfo
- Publication number
- ES484112A1 ES484112A1 ES484112A ES484112A ES484112A1 ES 484112 A1 ES484112 A1 ES 484112A1 ES 484112 A ES484112 A ES 484112A ES 484112 A ES484112 A ES 484112A ES 484112 A1 ES484112 A1 ES 484112A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- manufacture
- processes
- pharmaceutical compositions
- platelet aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Derivado de 1-bencil-1,2,3,6-tetrahidropiridina. Las sales de adición de ácido de los compuestos de la fórmula I que son especialmente aceptables desde el punto de vista farmacéutico son, por ejemplo, sales con ácidos inorgánicos tales como sales de clorhidratos, bromhidratos, sulfatos o fosfatos, o sales con ácidos orgánicos que ofrezcan un anión farmacéuticamente aceptable, tales como sales de tartratos, citratos, lactatos, fumaratos, tolueno-p-sultonatos u oxalatos. El proceso se efectúa convenientemente en un diluyente o disolvente inerte, tal como tetrahidrofurano cuando se emplea un hidruro de aluminio como agente reductor, o por ejemplo, un alcanol C1-4, tal como etanol, cuando su emplea un borohidruro o cianoborohidruro como agente reductor. De preferencia, el proceso se efectúa a la temperatura ambiente, aproximadamente, por ejemplo, entre los 15º y 35ºC.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1432378 | 1978-04-12 | ||
| GB7840272 | 1978-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484112A1 true ES484112A1 (es) | 1980-04-16 |
Family
ID=26250483
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479561A Expired ES479561A1 (es) | 1978-04-12 | 1979-04-11 | Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. |
| ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
| ES484112A Expired ES484112A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1,23,6-tetrahidropiridina |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479561A Expired ES479561A1 (es) | 1978-04-12 | 1979-04-11 | Procedimiento para la obtencion de derivados de 1-bencil-1,2,3,6-tetrahidropiridina. |
| ES484111A Expired ES484111A1 (es) | 1978-04-12 | 1979-09-12 | Procedimiento para la obtencion de derivados de 1-bencil-1, 2,3,6-tetrahidropiridina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4645771A (es) |
| EP (1) | EP0004727B1 (es) |
| AT (1) | AT371443B (es) |
| AU (1) | AU528873B2 (es) |
| CA (1) | CA1118778A (es) |
| DE (1) | DE2960612D1 (es) |
| DK (1) | DK152979A (es) |
| ES (3) | ES479561A1 (es) |
| FI (1) | FI791189A7 (es) |
| GR (1) | GR68387B (es) |
| HU (1) | HU178589B (es) |
| IL (1) | IL57249A (es) |
| NO (1) | NO152558C (es) |
| NZ (1) | NZ190092A (es) |
| PH (1) | PH14565A (es) |
| PT (1) | PT69489A (es) |
| ZW (1) | ZW7179A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| IL81264A (en) * | 1986-01-30 | 1990-11-05 | Takeda Chemical Industries Ltd | Quinone derivatives,their production and pharmaceutical compositions containing them |
| HU209573B (en) * | 1990-12-13 | 1994-08-29 | Richter Gedeon Vegyeszet | Process for producing of 1,2,3,6-tetrahydropyridine derivatives and pharmaceutical compositions comprising these substances |
| US5136040A (en) * | 1991-02-26 | 1992-08-04 | Eli Lilly And Company | Preparation of substituted tetrahydropyridines |
| CN1346347A (zh) * | 1999-02-08 | 2002-04-24 | 盐野义制药株式会社 | 环胺衍生物和它们的用途 |
| AU2001276716A1 (en) | 2000-08-08 | 2002-02-18 | Shionogi And Co., Ltd. | Cyclic amine derivatives and use thereof |
| EP1353636A1 (en) * | 2001-01-23 | 2003-10-22 | P & G-Clairol, Inc. | Novel couplers for use in oxidative hair dyeing |
| CN101376627B (zh) * | 2008-09-26 | 2012-05-09 | 上海应用技术学院 | 4-羟基苯甲酰氯的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3125488A (en) * | 1964-03-17 | Method of inducing analgesia by | ||
| CA778383A (en) * | 1968-02-13 | Marxer Adrian | N-phenyl-lower alkyl-pyridinium compounds and process for preparing same | |
| US2609270A (en) * | 1949-11-15 | 1952-09-02 | Inst Textile Tech | Mildewproof cellulose produced by reaction with chlord-benzyl quaternary ammonium salts |
| GB754372A (en) * | 1953-05-11 | 1956-08-08 | Schering Corp | Pyridine and piperidine derivatives |
| US2967182A (en) * | 1957-08-16 | 1961-01-03 | Lilly Co Eli | Novel substituted tetrahydropyridines |
| DE1445560C3 (de) * | 1961-02-27 | 1974-05-16 | Ciba-Geigy Ag, Basel (Schweiz) | N-Dichlorbenzyl-4-alkyl-pyridiniumsalze und Verfahren zu ihrer Herstellung. |
| US3284457A (en) * | 1964-01-17 | 1966-11-08 | Degussa | 1-lower alkyl-4-substituted phenyl-1, 2, 3, 6-tetrahydropyridines and acid addition salts |
| US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
| DE2101997A1 (en) * | 1971-01-16 | 1972-08-03 | Farbenfabriken Bayer AG, 509öfLeverkusen | 1-benzyl-4-subst-tetrahydropyridines - useful as intermediates for pharmaceuticals |
| DE2101998A1 (en) * | 1971-01-16 | 1972-08-03 | Bayer Ag | Tetrahydropyridines prepn - from 1-benzyl-tetrahydropyridines |
| US3758483A (en) * | 1971-05-28 | 1973-09-11 | Hoffmann La Roche | Tetrahydropyridine derivatives |
| ES425971A1 (es) * | 1974-05-04 | 1976-09-16 | Made Labor Sa | Procedimiento para la preparacion de 1,3,4 - trimetil - 2- (3,4,5-trimetoxibencil)- 1,2,5,6-tetrahidropiridina. |
| US4028371A (en) * | 1974-05-04 | 1977-06-07 | Laboratorios Made, S.A. | The compound 1,3,4-trimethyl-1-(3,4,5-trimethoxybenzyl)-1,2,5,6-tetrahydropyridine chloride |
| EP0004726B1 (en) * | 1978-04-12 | 1981-01-28 | Imperial Chemical Industries Plc | Blood platelet aggregation inhibitory tetrahydropyridine derivative, pharmaceutical compositions thereof and processes for its manufacture |
-
1979
- 1979-03-21 DE DE7979300447T patent/DE2960612D1/de not_active Expired
- 1979-03-21 EP EP79300447A patent/EP0004727B1/en not_active Expired
- 1979-03-31 GR GR58753A patent/GR68387B/el unknown
- 1979-04-02 NZ NZ190092A patent/NZ190092A/xx unknown
- 1979-04-03 CA CA000324750A patent/CA1118778A/en not_active Expired
- 1979-04-04 AU AU45817/79A patent/AU528873B2/en not_active Ceased
- 1979-04-10 PH PH22373A patent/PH14565A/en unknown
- 1979-04-10 ZW ZW71/79A patent/ZW7179A1/xx unknown
- 1979-04-11 NO NO791237A patent/NO152558C/no unknown
- 1979-04-11 FI FI791189A patent/FI791189A7/fi not_active Application Discontinuation
- 1979-04-11 DK DK152979A patent/DK152979A/da not_active IP Right Cessation
- 1979-04-11 HU HU79IE872A patent/HU178589B/hu unknown
- 1979-04-11 ES ES479561A patent/ES479561A1/es not_active Expired
- 1979-04-12 AT AT0275379A patent/AT371443B/de not_active IP Right Cessation
- 1979-04-12 PT PT69489A patent/PT69489A/pt unknown
- 1979-05-10 IL IL57249A patent/IL57249A/xx unknown
- 1979-09-12 ES ES484111A patent/ES484111A1/es not_active Expired
- 1979-09-12 ES ES484112A patent/ES484112A1/es not_active Expired
-
1982
- 1982-09-30 US US06/428,822 patent/US4645771A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0004727A3 (en) | 1979-10-31 |
| EP0004727A2 (en) | 1979-10-17 |
| ES484111A1 (es) | 1980-04-16 |
| IL57249A (en) | 1982-12-31 |
| AU528873B2 (en) | 1983-05-19 |
| US4645771A (en) | 1987-02-24 |
| IL57249A0 (en) | 1979-09-30 |
| NO152558B (no) | 1985-07-08 |
| DK152979A (da) | 1979-10-13 |
| AU4581779A (en) | 1979-10-18 |
| ES479561A1 (es) | 1979-12-01 |
| NZ190092A (en) | 1981-05-15 |
| GR68387B (es) | 1981-12-28 |
| ATA275379A (de) | 1982-11-15 |
| PT69489A (en) | 1979-05-01 |
| EP0004727B1 (en) | 1981-08-12 |
| NO791237L (no) | 1979-10-15 |
| ZW7179A1 (en) | 1980-11-26 |
| CA1118778A (en) | 1982-02-23 |
| HU178589B (en) | 1982-05-28 |
| NO152558C (no) | 1985-10-16 |
| PH14565A (en) | 1981-09-24 |
| AT371443B (de) | 1983-06-27 |
| FI791189A7 (fi) | 1981-01-01 |
| DE2960612D1 (en) | 1981-11-12 |
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