ES486556A1 - Procedimiento de preparacion de nuevos poli (h-) sulfatos derutina y sales de los mismos - Google Patents
Procedimiento de preparacion de nuevos poli (h-) sulfatos derutina y sales de los mismosInfo
- Publication number
- ES486556A1 ES486556A1 ES486556A ES486556A ES486556A1 ES 486556 A1 ES486556 A1 ES 486556A1 ES 486556 A ES486556 A ES 486556A ES 486556 A ES486556 A ES 486556A ES 486556 A1 ES486556 A1 ES 486556A1
- Authority
- ES
- Spain
- Prior art keywords
- sulfates
- preparation
- pharmaceutical compositions
- compositions containing
- rutin poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 title abstract 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 title abstract 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 title abstract 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 title abstract 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 title abstract 2
- 235000005493 rutin Nutrition 0.000 title abstract 2
- 229960004555 rutoside Drugs 0.000 title abstract 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- -1 salt cation Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedimiento para la preparación de nuevos poli (H-) sulfatos de rutina y sales de los mismos de fórmula: **(formula)** en donde R se selecciona del grupo que consiste en hidrógeno y -30 3A; en donde A es un catión de sal farmaceuticamente aceptable; con la condición de que por lo menos seis de los grupos R son -SO 3A; caracterizado porque comprende hacer reaccionar rutina en un solvente apropiado con un complejo de trialquilamina-trioxido de azufre a 50º -90º C, aislar la sal de sulfato de trialquilamina, seguido por tratamiento con un acetato de metal alcalino en solución acuosa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96642378A | 1978-12-04 | 1978-12-04 | |
| US6258779A | 1979-07-31 | 1979-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES486556A1 true ES486556A1 (es) | 1980-09-16 |
Family
ID=26742453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES486556A Expired ES486556A1 (es) | 1978-12-04 | 1979-12-03 | Procedimiento de preparacion de nuevos poli (h-) sulfatos derutina y sales de los mismos |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0013470B1 (es) |
| KR (1) | KR830001687B1 (es) |
| AR (1) | AR221383A1 (es) |
| AU (1) | AU530460B2 (es) |
| CA (1) | CA1139749A (es) |
| DD (1) | DD147544A5 (es) |
| DE (1) | DE2965524D1 (es) |
| DK (1) | DK513479A (es) |
| ES (1) | ES486556A1 (es) |
| IL (1) | IL58513A (es) |
| PL (1) | PL220109A1 (es) |
| YU (1) | YU285579A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0075626A1 (en) * | 1981-09-29 | 1983-04-06 | American Cyanamid Company | Novel rutin nona- and deca(H-)sulfate salts, methods of preparing novel salts, and use of novel salts of complement inhibitors |
| US4708949A (en) * | 1985-09-24 | 1987-11-24 | Yaguang Liu | Therapeutic composition from plant extracts |
| IT1245371B (it) * | 1991-03-28 | 1994-09-20 | Geymonat Spa | Derivati di flavoni, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |
| ES2041216B1 (es) * | 1992-02-25 | 1994-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2043455A1 (en) * | 1969-05-02 | 1971-02-19 | Melle Usine De | Water soluble propylsulphonates of rutin |
| DE1956016A1 (de) * | 1969-11-07 | 1971-05-13 | Blendax Werke Schneider Co | Praeparat zur Zahn- und Mundpflege |
-
1979
- 1979-10-21 IL IL58513A patent/IL58513A/xx unknown
- 1979-10-22 AU AU52025/79A patent/AU530460B2/en not_active Ceased
- 1979-10-26 DE DE7979302349T patent/DE2965524D1/de not_active Expired
- 1979-10-26 EP EP79302349A patent/EP0013470B1/en not_active Expired
- 1979-11-05 CA CA000339178A patent/CA1139749A/en not_active Expired
- 1979-11-08 AR AR278819A patent/AR221383A1/es active
- 1979-11-22 YU YU02855/79A patent/YU285579A/xx unknown
- 1979-11-30 DD DD79217287A patent/DD147544A5/de unknown
- 1979-12-03 DK DK513479A patent/DK513479A/da not_active Application Discontinuation
- 1979-12-03 ES ES486556A patent/ES486556A1/es not_active Expired
- 1979-12-03 KR KR1019790004248A patent/KR830001687B1/ko not_active Expired
- 1979-12-03 PL PL22010979A patent/PL220109A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1139749A (en) | 1983-01-18 |
| IL58513A0 (en) | 1980-01-31 |
| KR830001687B1 (ko) | 1983-08-29 |
| EP0013470A1 (en) | 1980-07-23 |
| DE2965524D1 (en) | 1983-07-07 |
| DK513479A (da) | 1980-06-05 |
| DD147544A5 (de) | 1981-04-08 |
| KR830001308A (ko) | 1983-04-30 |
| YU285579A (en) | 1983-02-28 |
| AU5202579A (en) | 1980-06-12 |
| AR221383A1 (es) | 1981-01-30 |
| AU530460B2 (en) | 1983-07-14 |
| EP0013470B1 (en) | 1983-05-25 |
| IL58513A (en) | 1982-11-30 |
| PL220109A1 (es) | 1981-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY103850A (en) | Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them. | |
| DE3473763D1 (en) | Novel 4'-demethyl-4-epipodophyllotoxin derivatives, a process for their preparation and their use as medicaments | |
| MY109669A (en) | N,o-sulphated heparosans, process for, preparing them and pharmaceutical compositions containing them | |
| IL66271A (en) | Substituted imidazole derivatives and their preparation and pharmaceutical compositions containing them | |
| ES8305285A1 (es) | Procedimiento para la obtencion de polimerizados lineales basicos. | |
| ES8604258A1 (es) | Un procedimiento para preparar una adenosina sustituida en n6 | |
| FR2412565A1 (fr) | Nouveaux derives de type n-acyl-2', n-alkyl-2', di-n-acyl-4,2', di-n-alkyl-4,2', n-acyl-4 n-alkyl-2' et n-alkyl-4 n-acyl-2', desoxy-2 fortimicine b | |
| ES425303A1 (es) | Un procedimiento de fabricacion de sales de heparina sim- ples. | |
| FR2412567A1 (fr) | N-acyl-2' et n-alkyl-2' o-demethyl-3 fortimicines a et b, utiles notamment comme antibiotiques | |
| JO1406B1 (en) | Chemical compounds | |
| FR2572399B1 (fr) | Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant | |
| DE3164763D1 (en) | Anthracycline glycosides, process for the preparation thereof, intermediate compounds and their preparation and pharmaceutical compositions | |
| FR2432520A1 (fr) | Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant | |
| ES8600261A1 (es) | Un compuesto fenoxi | |
| GB1506664A (en) | Antiviral compositions | |
| DE3170623D1 (en) | Guanidine derivatives and pharmaceutical compositions containing them | |
| WO1992009574A3 (en) | Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them | |
| ES8103112A1 (es) | Procedimiento para la obtencion de pseudo-trisacaridos | |
| ES8304152A1 (es) | Procedimiento para la obtencion de derivzados de aminociclitol. | |
| HUT43614A (en) | Process for producing isohexide-nucleosides and pharmaceutical compositions containing them | |
| HUT41022A (en) | Process for preparing 2-halogen-6-methyl-ergol-9-ene derivatives and acid additional salts thereof | |
| IL63132A0 (en) | Novel adenine nucleoside derivatives,their preparation andand pharmaceutical compositions containing them | |
| ES8202332A1 (es) | Un metodo para la preparacion de sales de 4'-(9-acridinila- mino)-metanosulfon-m-anisidida | |
| ES8800198A1 (es) | Procedimiento para preparar derivados de acidos aziridin-2- carboxilicos substituidos en n | |
| MY101765A (en) | Benzopyran derivatives, compositions containing them and processes for their production |