ES498793A0 - Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril--4-piperidincarboxilico. - Google Patents

Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril--4-piperidincarboxilico.

Info

Publication number
ES498793A0
ES498793A0 ES498793A ES498793A ES498793A0 ES 498793 A0 ES498793 A0 ES 498793A0 ES 498793 A ES498793 A ES 498793A ES 498793 A ES498793 A ES 498793A ES 498793 A0 ES498793 A0 ES 498793A0
Authority
ES
Spain
Prior art keywords
piperidincarboxilico
ciclohexil
aril
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES498793A
Other languages
English (en)
Other versions
ES8204421A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES498793A0 publication Critical patent/ES498793A0/es
Publication of ES8204421A1 publication Critical patent/ES8204421A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES498793A 1980-01-24 1981-01-23 Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril--4-piperidincarboxilico. Expired ES8204421A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (2)

Publication Number Publication Date
ES498793A0 true ES498793A0 (es) 1982-05-01
ES8204421A1 ES8204421A1 (es) 1982-05-01

Family

ID=26812674

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498793A Expired ES8204421A1 (es) 1980-01-24 1981-01-23 Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril--4-piperidincarboxilico.
ES508441A Expired ES8307219A1 (es) 1980-01-24 1981-12-30 Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril-4-piperidincarboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES508441A Expired ES8307219A1 (es) 1980-01-24 1981-12-30 Un procedimiento para la preparacion de nuevos derivados del acido 1-(ciclohexil)-4-aril-4-piperidincarboxilico.

Country Status (25)

Country Link
US (1) US4369184A (es)
EP (1) EP0034415B1 (es)
AU (1) AU538130B2 (es)
BG (2) BG35465A3 (es)
CA (1) CA1187080A (es)
CS (1) CS221818B2 (es)
DE (1) DE3163787D1 (es)
DK (1) DK152670C (es)
ES (2) ES8204421A1 (es)
FI (1) FI76562C (es)
GR (1) GR71898B (es)
HK (1) HK81088A (es)
HU (1) HU183293B (es)
IE (1) IE50706B1 (es)
IL (1) IL61968A (es)
LU (1) LU88220I2 (es)
MA (1) MA19046A1 (es)
MY (1) MY8700593A (es)
NL (1) NL930017I2 (es)
NO (1) NO1994012I1 (es)
NZ (1) NZ196117A (es)
PH (1) PH16611A (es)
PL (2) PL127679B1 (es)
SU (1) SU1230467A3 (es)
YU (1) YU48446B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk 1−ハイドロキシ−5−オキソ−5H−ピリド〔3,2−a〕フエノキサジン−3−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
AU1716995A (en) * 1994-03-18 1995-10-09 Ciba-Geigy Ag Aqueous solution of levocabastine for ophthalmic use
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
DE69733664T3 (de) 1996-04-19 2011-04-14 Grifols Inc. (n.d. Ges.d.Staates Delaware), Los Angeles Verfahren zur INaktivierung von Viren und Lyophilisierung von Blutproteinen
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
CA2495830C (en) 2002-08-30 2012-08-21 Altana Pharma Ag The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
KR101294014B1 (ko) * 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
CA2653953C (en) 2006-06-01 2015-12-08 Schering-Plough Healthcare Products, Inc. Phenylephrine pharmaceutical formulations and compositions for colonic absorption
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
BRPI0821647A2 (pt) * 2007-12-21 2015-06-16 Schering Plough Healthcare Realce da fotosestabillização de oximetazolina
ES2619829T3 (es) 2011-11-18 2017-06-27 Heptares Therapeutics Limited Agonistas del receptor muscarínico M1
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (es) * 1965-06-29

Also Published As

Publication number Publication date
IE810125L (en) 1981-07-24
DE3163787D1 (en) 1984-07-05
YU48446B (sh) 1998-07-10
PL233921A1 (es) 1982-06-21
ES508441A0 (es) 1983-07-01
HK81088A (en) 1988-10-14
BG60472B2 (bg) 1995-04-28
HU183293B (en) 1984-04-28
DK152670C (da) 1988-08-22
PL229365A1 (es) 1982-03-29
NZ196117A (en) 1984-05-31
DK29381A (da) 1981-07-25
EP0034415B1 (en) 1984-05-30
AU538130B2 (en) 1984-08-02
LU88220I2 (es) 1994-02-03
ES8204421A1 (es) 1982-05-01
GR71898B (es) 1983-08-11
CA1187080A (en) 1985-05-14
FI810193L (fi) 1981-07-25
NL930017I1 (nl) 1993-05-03
EP0034415A1 (en) 1981-08-26
NO1994012I1 (no) 1994-08-30
US4369184A (en) 1983-01-18
PL127679B1 (en) 1983-11-30
PL127483B1 (en) 1983-10-31
YU18381A (en) 1983-10-31
FI76562B (fi) 1988-07-29
PH16611A (en) 1983-11-24
NL930017I2 (nl) 1993-07-16
SU1230467A3 (ru) 1986-05-07
AU6625581A (en) 1981-07-30
MA19046A1 (fr) 1981-10-01
BG35465A3 (en) 1984-04-15
IL61968A0 (en) 1981-02-27
IL61968A (en) 1984-09-30
DK152670B (da) 1988-04-11
CS221818B2 (en) 1983-04-29
FI76562C (fi) 1988-11-10
IE50706B1 (en) 1986-06-25
ES8307219A1 (es) 1983-07-01
MY8700593A (en) 1987-12-31

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