MA19046A1 - Nouveau derive d'acides i-(cyclohexyl) -4-aryl-4-piperidinecarboxylique . - Google Patents

Nouveau derive d'acides i-(cyclohexyl) -4-aryl-4-piperidinecarboxylique .

Info

Publication number
MA19046A1
MA19046A1 MA19247A MA19247A MA19046A1 MA 19046 A1 MA19046 A1 MA 19046A1 MA 19247 A MA19247 A MA 19247A MA 19247 A MA19247 A MA 19247A MA 19046 A1 MA19046 A1 MA 19046A1
Authority
MA
Morocco
Prior art keywords
piperidinecarboxylique
cyclohexyl
aryl
acids
new derivative
Prior art date
Application number
MA19247A
Other languages
English (en)
Inventor
Luyckx M
Stockbroeks R
Willems J
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA19046A1 publication Critical patent/MA19046A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA19247A 1980-01-24 1981-01-22 Nouveau derive d'acides i-(cyclohexyl) -4-aryl-4-piperidinecarboxylique . MA19046A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
MA19046A1 true MA19046A1 (fr) 1981-10-01

Family

ID=26812674

Family Applications (1)

Application Number Title Priority Date Filing Date
MA19247A MA19046A1 (fr) 1980-01-24 1981-01-22 Nouveau derive d'acides i-(cyclohexyl) -4-aryl-4-piperidinecarboxylique .

Country Status (25)

Country Link
US (1) US4369184A (fr)
EP (1) EP0034415B1 (fr)
AU (1) AU538130B2 (fr)
BG (2) BG35465A3 (fr)
CA (1) CA1187080A (fr)
CS (1) CS221818B2 (fr)
DE (1) DE3163787D1 (fr)
DK (1) DK152670C (fr)
ES (2) ES8204421A1 (fr)
FI (1) FI76562C (fr)
GR (1) GR71898B (fr)
HK (1) HK81088A (fr)
HU (1) HU183293B (fr)
IE (1) IE50706B1 (fr)
IL (1) IL61968A (fr)
LU (1) LU88220I2 (fr)
MA (1) MA19046A1 (fr)
MY (1) MY8700593A (fr)
NL (1) NL930017I2 (fr)
NO (1) NO1994012I1 (fr)
NZ (1) NZ196117A (fr)
PH (1) PH16611A (fr)
PL (2) PL127679B1 (fr)
SU (1) SU1230467A3 (fr)
YU (1) YU48446B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk 1−ハイドロキシ−5−オキソ−5H−ピリド〔3,2−a〕フエノキサジン−3−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
WO1995025518A1 (fr) * 1994-03-18 1995-09-28 Ciba-Geigy Ag Solution aqueuse de levocabastine a usage ophtalmique
US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
JP2000509374A (ja) 1996-04-19 2000-07-25 アルファ セラピュティック コーポレイション 凍結乾燥した血液タンパク質のウイルス不活性化方法
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
PL373433A1 (en) * 2002-08-30 2005-08-22 Altana Pharma Ag The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
EP1976513B1 (fr) * 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamines inhibiteurs du recaptage des monoamines
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
CN104161736A (zh) 2006-06-01 2014-11-26 Msd消费保健品公司 包含去氧肾上腺素的缓释药物制剂
AU2008343045A1 (en) * 2007-12-21 2009-07-09 Msd Consumer Care, Inc. Enhancing photostabilization of oxymetazoline
CN104039321B (zh) 2011-11-18 2017-02-22 赫普泰雅治疗有限公司 药物化合物
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (fr) * 1965-06-29

Also Published As

Publication number Publication date
YU48446B (sh) 1998-07-10
CA1187080A (fr) 1985-05-14
NL930017I1 (nl) 1993-05-03
GR71898B (fr) 1983-08-11
SU1230467A3 (ru) 1986-05-07
HK81088A (en) 1988-10-14
ES8307219A1 (es) 1983-07-01
PH16611A (en) 1983-11-24
ES508441A0 (es) 1983-07-01
DE3163787D1 (en) 1984-07-05
LU88220I2 (fr) 1994-02-03
FI76562C (fi) 1988-11-10
PL233921A1 (fr) 1982-06-21
IE810125L (en) 1981-07-24
PL127483B1 (en) 1983-10-31
CS221818B2 (en) 1983-04-29
BG60472B2 (bg) 1995-04-28
NO1994012I1 (no) 1994-08-30
AU538130B2 (en) 1984-08-02
HU183293B (en) 1984-04-28
NL930017I2 (nl) 1993-07-16
IL61968A0 (en) 1981-02-27
BG35465A3 (en) 1984-04-15
MY8700593A (en) 1987-12-31
PL229365A1 (fr) 1982-03-29
YU18381A (en) 1983-10-31
IL61968A (en) 1984-09-30
FI810193L (fi) 1981-07-25
DK29381A (da) 1981-07-25
EP0034415B1 (fr) 1984-05-30
FI76562B (fi) 1988-07-29
ES498793A0 (es) 1982-05-01
DK152670C (da) 1988-08-22
US4369184A (en) 1983-01-18
PL127679B1 (en) 1983-11-30
ES8204421A1 (es) 1982-05-01
DK152670B (da) 1988-04-11
EP0034415A1 (fr) 1981-08-26
NZ196117A (en) 1984-05-31
IE50706B1 (en) 1986-06-25
AU6625581A (en) 1981-07-30

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