ES524186A0 - Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina. - Google Patents

Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Info

Publication number
ES524186A0
ES524186A0 ES524186A ES524186A ES524186A0 ES 524186 A0 ES524186 A0 ES 524186A0 ES 524186 A ES524186 A ES 524186A ES 524186 A ES524186 A ES 524186A ES 524186 A0 ES524186 A0 ES 524186A0
Authority
ES
Spain
Prior art keywords
triacine
pirimidine
procedure
preparation
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES524186A
Other languages
English (en)
Other versions
ES8500912A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lpb Istituto Farmaceutico SpA
Original Assignee
Lpb Istituto Farmaceutico SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lpb Istituto Farmaceutico SpA filed Critical Lpb Istituto Farmaceutico SpA
Publication of ES524186A0 publication Critical patent/ES524186A0/es
Publication of ES8500912A1 publication Critical patent/ES8500912A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES524186A 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina. Expired ES8500912A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8123580A IT1211096B (it) 1981-08-20 1981-08-20 Pirimidine e s.triazinici adattivita' ipolipidemizzante.

Publications (2)

Publication Number Publication Date
ES524186A0 true ES524186A0 (es) 1984-11-16
ES8500912A1 ES8500912A1 (es) 1984-11-16

Family

ID=11208290

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515104A Granted ES515104A0 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".
ES524186A Expired ES8500912A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.
ES524185A Expired ES8504741A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515104A Granted ES515104A0 (es) 1981-08-20 1982-08-19 "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES524185A Expired ES8504741A1 (es) 1981-08-20 1983-07-16 Procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina.

Country Status (9)

Country Link
US (1) US4559345A (es)
EP (1) EP0073328A1 (es)
JP (1) JPS5869870A (es)
CA (1) CA1173036A (es)
DE (1) DE73328T1 (es)
DK (1) DK373782A (es)
ES (3) ES515104A0 (es)
IT (1) IT1211096B (es)
PH (1) PH17607A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
US4542216A (en) * 1984-03-27 1985-09-17 Ciba Geigy Corporation Process for producing fluoroalkoxyaminopyrimidines
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
JPH0631238B2 (ja) * 1985-08-01 1994-04-27 日産化学工業株式会社 ピラゾロ〔４，３−ｄ〕ピリミジン誘導体
GB8911287D0 (en) * 1989-05-17 1989-07-05 Ciba Geigy Ag Lubricant compositions
DE4104466A1 (de) * 1990-03-09 1991-09-12 Huels Chemische Werke Ag Quartaere ammoniumsalze von thiobarbitursaeuren und verfahren zu deren herstellung
AU1507199A (en) 1997-12-15 1999-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel pyrimidine-5-carboxamide derivatives
PL350050A1 (en) 1999-01-22 2002-10-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
CN1231212C (zh) 1999-01-22 2005-12-14 依兰制药公司 抑制vla－4介导的白细胞粘着的多环化合物
IL143928A0 (en) * 1999-01-22 2002-04-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
ATE264298T1 (de) 1999-03-01 2004-04-15 Elan Pharm Inc Alpha-aminoessigsäure derivate als alpha 4 beta 7-rezeptor antagonisten
IL156315A0 (en) 2000-12-07 2004-01-04 Cv Therapeutics Inc Abca-1 elevating compounds
US20030125338A1 (en) * 2001-06-12 2003-07-03 Active Pass Pharmaceuticals, Inc. Compounds, compositions and methods for modulating beta-amyloid production
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
DE102005025161A1 (de) * 2005-06-01 2006-12-07 Phenion Gmbh & Co. Kg Derivate des Pyrimidins und Triazins und deren Verwendung
CA2624524C (en) * 2005-09-29 2014-07-08 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
ATE493405T1 (de) * 2005-09-29 2011-01-15 Elan Pharm Inc Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
WO2007101165A1 (en) 2006-02-27 2007-09-07 Elan Pharmaceuticals, Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
AU2010241742A1 (en) * 2009-04-27 2011-11-17 Elan Pharmaceuticals, Inc. Pyridinone antagonists of alpha-4 integrins
JP2023551637A (ja) * 2020-11-06 2023-12-12 ペレメッド カンパニー リミテッド 新規なカプシド組み立て阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB744867A (en) * 1952-10-29 1956-02-15 American Cyanamid Co Improvements relating to 2-substituted-mercapto-4-amino-6-disubstituted-aminopyrimidines and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR1413722A (fr) * 1963-11-12 1965-10-08 Geigy Ag J R Nouveaux dérivés de la pyrimidine, leur préparation et leurs applications
CH481986A (de) * 1967-05-24 1969-11-30 Geigy Ag J R Verfahren zur Herstellung von wasserlöslichen Farbsalzen von Azopyrimidinfarbstoffen
US3814761A (en) * 1972-03-31 1974-06-04 American Home Prod (2-pyrimidinylthio)alkanoic acids,esters,amides and hydrazides
US3974162A (en) * 1972-12-21 1976-08-10 American Home Products Corporation 4-Pyrimidinylthioacetic acid derivatives
DE2549161A1 (de) * 1975-11-03 1977-05-12 Henkel & Cie Gmbh Farbentwickler fuer farbphotographische entwicklungsverfahren
IT1063074B (it) * 1976-03-17 1985-02-11 Lpb Ist Farm Ammidi di acidi(z-pirimidiniltio)al canoici quali agent antilipemici

Also Published As

Publication number Publication date
ES524185A0 (es) 1985-05-01
IT8123580A0 (it) 1981-08-20
PH17607A (en) 1984-10-05
US4559345A (en) 1985-12-17
CA1173036A (en) 1984-08-21
ES8500912A1 (es) 1984-11-16
ES8401037A1 (es) 1983-12-16
ES8504741A1 (es) 1985-05-01
ES515104A0 (es) 1983-12-16
IT1211096B (it) 1989-09-29
DK373782A (da) 1983-02-21
JPS5869870A (ja) 1983-04-26
EP0073328A1 (en) 1983-03-09
DE73328T1 (de) 1983-07-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009