ES526331A0 - Procedimiento para preparar formas de mopidamol como granulados, granulos o tabletas - Google Patents

Procedimiento para preparar formas de mopidamol como granulados, granulos o tabletas

Info

Publication number: ES526331A0
Authority: ES; Spain
Prior art keywords: acid; mopidamol; addition salt; granulates; granules
Prior art date: 1982-10-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES526331A

Other languages

English (en)

Other versions

ES8500743A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-09

Filing date

1983-10-07

Publication date

1984-11-01

1983-10-07 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1984-11-01 Publication of ES526331A0 publication Critical patent/ES526331A0/es

1984-11-01 Publication of ES8500743A1 publication Critical patent/ES8500743A1/es

Status Expired legal-status Critical Current

Links

FOYWNSCCNCUEPU-UHFFFAOYSA-N mopidamol Chemical compound C12=NC(N(CCO)CCO)=NC=C2N=C(N(CCO)CCO)N=C1N1CCCCC1 FOYWNSCCNCUEPU-UHFFFAOYSA-N 0.000 title abstract 4
229950010718 mopidamol Drugs 0.000 title abstract 4
239000008187 granular material Substances 0.000 title 2
239000002253 acid Substances 0.000 abstract 9
150000003839 salts Chemical class 0.000 abstract 3
239000000126 substance Substances 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000036210 malignancy Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Detergent Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ES526331A 1982-10-09 1983-10-07 Procedimiento para preparar formas de mopidamol como granulados, granulos o tabletas Expired ES8500743A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823237575 DE3237575A1 (de)	1982-10-09	1982-10-09	Neue orale mopidamolformen

Publications (2)

Publication Number	Publication Date
ES526331A0 true ES526331A0 (es)	1984-11-01
ES8500743A1 ES8500743A1 (es)	1984-11-01

Family

ID=6175408

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES526331A Expired ES8500743A1 (es)	1982-10-09	1983-10-07	Procedimiento para preparar formas de mopidamol como granulados, granulos o tabletas

Country Status (18)

Country	Link
US (2)	US4596705A (es)
EP (1)	EP0108898B1 (es)
JP (1)	JPH07558B2 (es)
AT (1)	ATE21481T1 (es)
AU (1)	AU560251B2 (es)
CA (1)	CA1228546A (es)
DE (2)	DE3237575A1 (es)
DK (1)	DK158541C (es)
ES (1)	ES8500743A1 (es)
FI (1)	FI79650C (es)
GB (1)	GB2128088B (es)
GR (1)	GR79015B (es)
IE (1)	IE56058B1 (es)
IL (1)	IL69930A (es)
NO (1)	NO833638L (es)
NZ (1)	NZ205894A (es)
PT (1)	PT77467B (es)
ZA (1)	ZA837499B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3237575A1 (de) *	1982-10-09	1984-04-12	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue orale mopidamolformen
GB8414220D0 (en) *	1984-06-04	1984-07-11	Sterwin Ag	Medicaments in unit dose form
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
CA1323833C (en) *	1987-04-28	1993-11-02	Yatindra M. Joshi	Pharmaceutical compositions in the form of beadlets and method
US5364646A (en) *	1990-01-10	1994-11-15	Dr. Karl Thomae Gmbh	Oral pharmaceutical forms of pimobendan
CA2039742A1 (en) *	1990-04-23	1991-10-24	Andrew B. Dennis	Tablet composition and method for problem pharmaceutical materials
US5156845A (en) *	1990-05-04	1992-10-20	Colgate-Palmolive Company	Dry mouth lozenge
US5523289A (en) *	1991-04-15	1996-06-04	Abbott Laboratories	Pharmaceutical composition
WO1992020326A1 (en) *	1991-05-20	1992-11-26	Marion Laboratories, Inc.	Multi-layered controlled release formulation
EP1093814A1 (en) *	1999-10-22	2001-04-25	Boehringer Ingelheim Pharma KG	Use of dipyridamole or mopidamol in the manufacture of a medicament for the treatment and prevention of fibrin-dependent microcirculation disorders
NZ521034A (en) *	2000-02-28	2004-08-27	Vectura Ltd	Improvements in or relating to the delivery of oral drugs
US7064130B2 (en) *	2001-04-20	2006-06-20	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Use of radical-scavenging compounds for treatment and prevention of NO-dependent microcirculation disorders
US20030181488A1 (en)	2002-03-07	2003-09-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
WO2004050068A1 (en) *	2002-11-29	2004-06-17	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
JP2006516593A (ja) *	2003-02-07	2006-07-06	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｍｍｐ−９依存性疾患の治療及び予防のためのジピリダモール又はモピダモールの使用
JP2006524203A (ja)	2003-04-24	2006-10-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	トロンビンの過剰形成及び／又はトロンビンレセプターの発現上昇により生じる血栓塞栓性疾病及び疾患の治療及び予防のためのジピリダモール又はモピダモールの使用
DE602004030931D1 (es)	2003-11-04	2011-02-17	Supernus Pharmaceuticals Inc
US8709476B2 (en) *	2003-11-04	2014-04-29	Supernus Pharmaceuticals, Inc.	Compositions of quaternary ammonium compounds containing bioavailability enhancers
DE102004011512B4 (de) *	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
PT2559430E (pt)	2005-03-22	2015-10-09	Stada Arzneimittel Ag	Ibuprofeno solubilizado
EP1915137B8 (de) *	2005-08-10	2013-09-11	ADD Advanced Drug Delivery Technologies, Ltd.	Orales präparat mit kontrollierter freisetzung
KR20140088230A (ko) *	2006-01-27	2014-07-09	앱탈리스 파마테크, 인코포레이티드	약 염기성 약물과 유기산을 포함하는 약물 전달 시스템
CN101410094B (zh) *	2006-01-27	2013-04-17	阿普塔利斯制药股份有限公司	包含弱碱性选择性5-羟色胺5-ht3阻断剂和有机酸的药物递送系统
US7731604B2 (en) *	2006-10-31	2010-06-08	Taylor Made Golf Company, Inc.	Golf club iron head
EP1920785A1 (en)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Liquid preparation comprising a complex of pimobendan and cyclodextrin
UA97813C2 (uk) *	2006-12-05	2012-03-26	Янссен Фармацевтика Н.В.	Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
US8133506B2 (en) *	2008-03-12	2012-03-13	Aptalis Pharmatech, Inc.	Drug delivery systems comprising weakly basic drugs and organic acids
EP2370070B9 (en)	2008-11-25	2014-04-23	Boehringer Ingelheim Vetmedica GmbH	Pimobendan for use in the treatment of hypertrophic cardiomyopathy in cats.
US20110003005A1 (en) *	2009-07-06	2011-01-06	Gopi Venkatesh	Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions
HUE060093T2 (hu)	2012-03-15	2023-01-28	Boehringer Ingelheim Vetmedica Gmbh	Gyógyszerészeti tablettakészítmény az állatgyógyászati ágazat számára, eljárás annak elõállítására és annak alkalmazása
PL2898886T3 (pl) *	2012-09-19	2017-06-30	Taiho Pharmaceutical Co., Ltd.	Kompozycja farmaceutyczna do podawania doustnego z polepszoną elucją i/lub wchłanianiem
HUE054186T2 (hu)	2013-07-19	2021-08-30	Boehringer Ingelheim Vetmedica Gmbh	Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény
ES2883448T3 (es)	2013-12-04	2021-12-07	Boehringer Ingelheim Vetmedica Gmbh	Composiciones farmacéuticas mejoradas de pimobendán
JP6525897B2 (ja) *	2016-01-21	2019-06-05	日清オイリオグループ株式会社	タブレットの硬度調整剤
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN109942445A (zh) *	2019-02-26	2019-06-28	山东瑞弘生物科技有限公司	甜菜碱盐酸盐合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3322755A (en)	1964-03-10	1967-05-30	Boehringer Sohn Ingelheim	Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
DD146547A5 (de) *	1978-07-15	1981-02-18	Boehringer Sohn Ingelheim	Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
EP0019586A1 (de) *	1979-05-11	1980-11-26	Ciba-Geigy Ag	Neue antithrombotische Kombinationspräparate
DE2931573A1 (de) *	1979-08-03	1981-02-26	Thomae Gmbh Dr K	Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3000979A1 (de) *	1980-01-12	1981-07-23	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
DE3124090A1 (de) *	1981-06-19	1983-01-05	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue orale dipyridamolformen
DE3126703A1 (de) *	1981-07-07	1983-01-27	Dr. Karl Thomae Gmbh, 7950 Biberach	Bromhexin-retardform und verfahren zu ihrer herstellung
DE3237575A1 (de) *	1982-10-09	1984-04-12	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue orale mopidamolformen

1982
- 1982-10-09 DE DE19823237575 patent/DE3237575A1/de not_active Withdrawn
1983
- 1983-09-24 AT AT83109510T patent/ATE21481T1/de not_active IP Right Cessation
- 1983-09-24 EP EP83109510A patent/EP0108898B1/de not_active Expired
- 1983-09-24 DE DE8383109510T patent/DE3365465D1/de not_active Expired
- 1983-10-05 FI FI833605A patent/FI79650C/fi not_active IP Right Cessation
- 1983-10-06 NO NO833638A patent/NO833638L/no unknown
- 1983-10-06 DK DK460683A patent/DK158541C/da not_active IP Right Cessation
- 1983-10-07 GR GR72641A patent/GR79015B/el unknown
- 1983-10-07 ES ES526331A patent/ES8500743A1/es not_active Expired
- 1983-10-07 CA CA000438670A patent/CA1228546A/en not_active Expired
- 1983-10-07 IE IE2358/83A patent/IE56058B1/en not_active IP Right Cessation
- 1983-10-07 GB GB08326877A patent/GB2128088B/en not_active Expired
- 1983-10-07 ZA ZA837499A patent/ZA837499B/xx unknown
- 1983-10-07 PT PT77467A patent/PT77467B/pt not_active IP Right Cessation
- 1983-10-07 IL IL69930A patent/IL69930A/xx not_active IP Right Cessation
- 1983-10-07 AU AU19985/83A patent/AU560251B2/en not_active Ceased
- 1983-10-07 NZ NZ205894A patent/NZ205894A/en unknown
- 1983-10-07 JP JP58188283A patent/JPH07558B2/ja not_active Expired - Lifetime
- 1983-10-07 US US06/539,998 patent/US4596705A/en not_active Expired - Lifetime
1985
- 1985-09-03 US US06/772,166 patent/US4650664A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ZA837499B (en)	1985-06-26
US4596705A (en)	1986-06-24
JPH07558B2 (ja)	1995-01-11
FI833605A0 (fi)	1983-10-05
NZ205894A (en)	1986-08-08
IE56058B1 (en)	1991-04-10
FI79650C (fi)	1990-02-12
EP0108898B1 (de)	1986-08-20
DK158541C (da)	1990-11-05
PT77467A (de)	1983-11-01
ES8500743A1 (es)	1984-11-01
DK460683A (da)	1984-04-10
AU560251B2 (en)	1987-04-02
DE3365465D1 (en)	1986-09-25
IL69930A0 (en)	1984-01-31
GR79015B (es)	1984-10-02
GB2128088B (en)	1986-04-30
IL69930A (en)	1986-08-31
EP0108898A1 (de)	1984-05-23
PT77467B (de)	1986-05-07
CA1228546A (en)	1987-10-27
ATE21481T1 (de)	1986-09-15
DK460683D0 (da)	1983-10-06
IE832358L (en)	1984-04-09
NO833638L (no)	1984-04-10
US4650664A (en)	1987-03-17
FI79650B (fi)	1989-10-31
FI833605L (fi)	1984-04-10
GB8326877D0 (en)	1983-11-09
GB2128088A (en)	1984-04-26
JPS5989615A (ja)	1984-05-23
DE3237575A1 (de)	1984-04-12
DK158541B (da)	1990-06-05
AU1998583A (en)	1984-04-12

Publication	Publication Date	Title
ES526331A0 (es)	1984-11-01	Procedimiento para preparar formas de mopidamol como granulados, granulos o tabletas
ES8304797A1 (es)	1983-03-16	"procedimiento para la preparacion de nuevas formas orales de dipiridamol, en forma de granulados, pastillas o tabletas".
DK0754176T3 (da)	2002-04-02	Hidtil ukendte carbamater og urinstoffer som modifikatorer for multidrugsresistens
PT92821A (pt)	1990-07-31	Processo para a preparacao composicoes farmaceuticas para o combate de doencas do tipo psoriase, bem como doencas inflamatorias, incorporando azelastina como substancia activa
DE3166111D1 (en)	1984-10-25	Pharmaceutical composition for healing inflammatory and/or degenerative and/or atrophic mucous membranes
ES8609312A1 (es)	1986-09-01	Procedimiento para la preparacion de silibinina exenta de isosilibina
ATE47035T1 (de)	1989-10-15	Kit oder vorrichtung und methode zum verabreichen von gangliosiden und deren derivate durch inhalation und dafuer geeignete pharmazeutische zusammensetzungen.
JPS57122085A (en)	1982-07-29	Circulatory disease extirpenter and use
HU9401656D0 (en)	1994-09-28	Pharmaceutical composition for treating tumours, containing creatine phosphate or phospho-enol-pyruvic acid
ATE251631T1 (de)	2003-10-15	Dipohosphonsäuresalze für die behandlung von osteoporose
DE3380923D1 (de)	1990-01-11	Pharmazeutische zusammensetzungen zur behandlung von stoerungen, bedingt durch humanendrogen.
DK229984A (da)	1984-11-11	4-oxothiazolidin-2-yliden-acetamidderivater
DE3162277D1 (en)	1984-03-22	N-(4-phenyl-2-thiazolyl)-oxamidic-acid-2-ethoxyethylester, process for its preparation and pharmaceutical compositions containing this compound
DE69009765D1 (de)	1994-07-14	Kynurensäurederivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE3160018D1 (en)	1983-01-27	Use of s-benzyl-3-benzylthiopropionthioate in pharmaceutical compositions
DE3161400D1 (en)	1983-12-22	5-alkyl-3-alkylthiopropionthioates, process for their preparation and their use as pharmaceutical compositions
ATE95062T1 (de)	1993-10-15	Zusammensetzung zur behandlung von krebs, gekennzeichnet durch ueberexpression des c-fmsproto-onkogens.
DK32893A (da)	1993-03-22	Geminale cycloalkyldiphosphonsyrer og farmaceutisk acceptable salte heraf samt farmaceutisk sammensaetning omfattende samme
MX9602846A (es)	1997-12-31	Compuestos de vanadato para el tratamiento de desordenes proliferativos, metastasis, y tumores resistentes a los farmacos.