ES531004A0 - Un metodo de preparar compuestos de diaminopirimidina - Google Patents
Un metodo de preparar compuestos de diaminopirimidinaInfo
- Publication number
- ES531004A0 ES531004A0 ES531004A ES531004A ES531004A0 ES 531004 A0 ES531004 A0 ES 531004A0 ES 531004 A ES531004 A ES 531004A ES 531004 A ES531004 A ES 531004A ES 531004 A0 ES531004 A0 ES 531004A0
- Authority
- ES
- Spain
- Prior art keywords
- diaminopyrimidine compounds
- preparing
- preparing diaminopyrimidine
- compounds
- diaminopyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41640482A | 1982-09-09 | 1982-09-09 | |
| US06/520,653 US4532240A (en) | 1982-09-09 | 1983-08-09 | Diaminopyrimidines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES531004A0 true ES531004A0 (es) | 1985-05-01 |
| ES8504775A1 ES8504775A1 (es) | 1985-05-01 |
Family
ID=27023342
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525490A Expired ES8502989A1 (es) | 1982-09-09 | 1983-09-08 | Un metodo de preparar compuestos de diaminopirimidina |
| ES531004A Expired ES8504775A1 (es) | 1982-09-09 | 1984-03-27 | Un metodo de preparar compuestos de diaminopirimidina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525490A Expired ES8502989A1 (es) | 1982-09-09 | 1983-09-08 | Un metodo de preparar compuestos de diaminopirimidina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4532240A (es) |
| EP (1) | EP0103464B1 (es) |
| AU (2) | AU560971B2 (es) |
| CA (1) | CA1251447A (es) |
| DE (1) | DE3378469D1 (es) |
| DK (1) | DK158310C (es) |
| ES (2) | ES8502989A1 (es) |
| GR (1) | GR79058B (es) |
| IE (1) | IE56148B1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5099019A (en) * | 1985-09-12 | 1992-03-24 | Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| USRE35053E (en) * | 1985-09-12 | 1995-10-10 | The Upjohn Company | Amines useful in producing pharmaceutically active CNS compounds |
| LU86695A1 (fr) * | 1986-12-01 | 1988-07-14 | Oreal | Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique |
| HUT64323A (en) * | 1992-06-09 | 1993-12-28 | Richter Gedeon Vegyeszet | Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives |
| ATE166347T1 (de) * | 1993-02-26 | 1998-06-15 | Max Delbrueck Centrum | Verfahren zur herstellung von c-nukleosiden und c-nukleosid-analoga, neue c-nukleoside und c- nukleosid-analoga, sowie ihre verwendung |
| DE4320570C2 (de) * | 1993-02-26 | 2002-07-11 | Max Delbrueck Centrum | Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga sowie deren Verwendung |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| AU2076299A (en) | 1998-01-30 | 1999-08-16 | Meiji Seika Kaisha Ltd. | Phenylpiperazine derivatives as integrin alphavbeta3 antagonists |
| US20040006042A1 (en) * | 1998-08-13 | 2004-01-08 | Berry David Allen | Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers |
| AU4690999A (en) * | 1998-08-13 | 2000-03-06 | Warner-Lambert Company | Diaminopyrimidines and combination therapies effective for treatment of p-glycoprotein positive cancers |
| BR0209932A (pt) * | 2001-05-22 | 2004-10-13 | Neurogen Corp | Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto |
| GB0412072D0 (en) * | 2004-05-28 | 2004-06-30 | Syngenta Participations Ag | Chemical compounds |
| JP6949055B2 (ja) * | 2016-02-05 | 2021-10-13 | ヴェラ ファーマシューティカルズ，エルエルシー | 感染症を治療するための組成物および方法 |
| WO2019032458A1 (en) * | 2017-08-07 | 2019-02-14 | Vyera Pharmaceuticals, LLC | DHFR INHIBITORS, COMPOSITIONS AND RELATED METHODS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US416404A (en) | 1889-12-03 | Automatic lath-feeder for paper-carriers | ||
| BE485737A (es) * | 1947-11-12 | |||
| US2748125A (en) * | 1954-04-26 | 1956-05-29 | American Cyanamid Co | 1-substituted-4-sulfamylpiperazine and method of preparing the same |
| AT340933B (de) * | 1973-08-20 | 1978-01-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze |
| US4166852A (en) * | 1974-08-09 | 1979-09-04 | Produits Chimiques Ugine Kuhlmann | Piperazino-pyrimidines and their use as spasmolytic agents |
| US4287338A (en) * | 1980-03-10 | 1981-09-01 | The Upjohn Company | Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts |
| US4351832A (en) * | 1980-04-18 | 1982-09-28 | American Home Products Corporation | 2-(Piperazinyl)-4-pyrimidinamines |
-
1983
- 1983-08-09 US US06/520,653 patent/US4532240A/en not_active Expired - Lifetime
- 1983-08-16 IE IE1920/83A patent/IE56148B1/en not_active IP Right Cessation
- 1983-09-05 AU AU18699/83A patent/AU560971B2/en not_active Ceased
- 1983-09-07 GR GR72395A patent/GR79058B/el unknown
- 1983-09-08 CA CA000436240A patent/CA1251447A/en not_active Expired
- 1983-09-08 EP EP83305229A patent/EP0103464B1/en not_active Expired
- 1983-09-08 DK DK407383A patent/DK158310C/da not_active IP Right Cessation
- 1983-09-08 ES ES525490A patent/ES8502989A1/es not_active Expired
- 1983-09-08 DE DE8383305229T patent/DE3378469D1/de not_active Expired
-
1984
- 1984-03-27 ES ES531004A patent/ES8504775A1/es not_active Expired
-
1987
- 1987-02-13 AU AU68787/87A patent/AU568997B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0103464A3 (en) | 1985-07-03 |
| DK407383A (da) | 1984-03-10 |
| DK158310C (da) | 1990-10-15 |
| AU6878787A (en) | 1987-05-14 |
| US4532240A (en) | 1985-07-30 |
| CA1251447A (en) | 1989-03-21 |
| GR79058B (es) | 1984-10-02 |
| EP0103464B1 (en) | 1988-11-17 |
| ES525490A0 (es) | 1985-02-01 |
| AU568997B2 (en) | 1988-01-14 |
| ES8502989A1 (es) | 1985-02-01 |
| DK158310B (da) | 1990-04-30 |
| DE3378469D1 (en) | 1988-12-22 |
| IE831920L (en) | 1984-03-09 |
| AU1869983A (en) | 1984-03-15 |
| EP0103464A2 (en) | 1984-03-21 |
| DK407383D0 (da) | 1983-09-08 |
| IE56148B1 (en) | 1991-05-08 |
| AU560971B2 (en) | 1987-04-30 |
| ES8504775A1 (es) | 1985-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20040216 |