ES544417A0 - Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas. - Google Patents

Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.

Info

Publication number: ES544417A0
Authority: ES; Spain
Prior art keywords: group; acid addition; addition salts; compounds; alkyl group
Prior art date: 1984-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES544417A

Other languages

English (en)

Other versions

ES8604590A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-22

Filing date

1985-06-21

Publication date

1986-02-01

1985-06-21 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1986-02-01 Publication of ES544417A0 publication Critical patent/ES544417A0/es

1986-02-01 Publication of ES8604590A1 publication Critical patent/ES8604590A1/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
206010027476 Metastases Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES544417A 1984-06-22 1985-06-21 Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas. Expired ES8604590A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843423092 DE3423092A1 (de)	1984-06-22	1984-06-22	Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number	Publication Date
ES544417A0 true ES544417A0 (es)	1986-02-01
ES8604590A1 ES8604590A1 (es)	1986-02-01

Family

ID=6238919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES544417A Expired ES8604590A1 (es)	1984-06-22	1985-06-21	Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.

Country Status (19)

Country	Link
US (1)	US4714698A (es)
EP (1)	EP0167817B1 (es)
JP (1)	JPH0694465B2 (es)
KR (1)	KR920007435B1 (es)
AT (1)	ATE46511T1 (es)
AU (1)	AU579869B2 (es)
CA (1)	CA1241325A (es)
DE (2)	DE3423092A1 (es)
DK (1)	DK282285A (es)
ES (1)	ES8604590A1 (es)
FI (1)	FI80455C (es)
GR (1)	GR851467B (es)
IE (1)	IE58432B1 (es)
IL (1)	IL75596A0 (es)
NO (1)	NO161620C (es)
NZ (1)	NZ212515A (es)
PH (1)	PH21319A (es)
PT (1)	PT80670B (es)
ZA (1)	ZA854683B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH075594B2 (ja) *	1986-03-25	1995-01-25	三井石油化学工業株式会社	新規ピリドピリミジン誘導体
GB8719368D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Heterocyclic compounds
US4885300A (en) *	1988-03-03	1989-12-05	Ortho Pharmaceutical Corporation	4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
DE4325900A1 (de) *	1993-08-02	1995-02-09	Thomae Gmbh Dr K	Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW414798B (en) *	1994-09-07	2000-12-11	Thomae Gmbh Dr K	Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) *	1996-03-06	1997-09-11	Thomae Gmbh Dr K	Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2006074147A2 (en)	2005-01-03	2006-07-13	Myriad Genetics, Inc.	Nitrogen containing bicyclic compounds and therapeutical use thereof
US8309562B2 (en) *	2003-07-03	2012-11-13	Myrexis, Inc.	Compounds and therapeutical use thereof
WO2005003100A2 (en)	2003-07-03	2005-01-13	Myriad Genetics, Inc.	4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8258145B2 (en) *	2005-01-03	2012-09-04	Myrexis, Inc.	Method of treating brain cancer
ATE549338T1 (de) *	2006-05-24	2012-03-15	Boehringer Ingelheim Int	Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1116676B (de) *	1955-03-14	1961-11-09	Thomae Gmbh Dr K	Verfahren zur Herstellung von Pyrimido [5, 4-d] pyrimidinen
US3031450A (en) *	1959-04-30	1962-04-24	Thomae Gmbh Dr K	Substituted pyrimido-[5, 4-d]-pyrimidines
US3322755A (en) *	1964-03-10	1967-05-30	Boehringer Sohn Ingelheim	Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
GB1190419A (en) *	1966-08-16	1970-05-06	Yamanouchi Pharma Co Ltd	Substituted Pyrimido-Pyrimidines and a process for the preparation thereof
DE2926804A1 (de) *	1979-07-03	1981-01-22	Thomae Gmbh Dr K	Neue 2-(perhydro-1,4-diazino)-pyrimido- eckige klammer auf 5,4-d eckige klammer zu pyrimidine, deren herstellung und verwendung als arzneimittel
EP0023559B1 (de) *	1979-07-03	1984-09-19	Dr. Karl Thomae GmbH	2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) *	1980-12-27	1982-07-29	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel

1984
- 1984-06-22 DE DE19843423092 patent/DE3423092A1/de not_active Withdrawn
1985
- 1985-06-04 DE DE8585106900T patent/DE3573119D1/de not_active Expired
- 1985-06-04 AT AT85106900T patent/ATE46511T1/de not_active IP Right Cessation
- 1985-06-04 EP EP85106900A patent/EP0167817B1/de not_active Expired
- 1985-06-17 GR GR851467A patent/GR851467B/el unknown
- 1985-06-17 US US06/745,095 patent/US4714698A/en not_active Expired - Fee Related
- 1985-06-20 PT PT80670A patent/PT80670B/pt not_active IP Right Cessation
- 1985-06-20 FI FI852445A patent/FI80455C/fi not_active IP Right Cessation
- 1985-06-21 ZA ZA854683A patent/ZA854683B/xx unknown
- 1985-06-21 NZ NZ212515A patent/NZ212515A/xx unknown
- 1985-06-21 DK DK282285A patent/DK282285A/da not_active Application Discontinuation
- 1985-06-21 AU AU43968/85A patent/AU579869B2/en not_active Ceased
- 1985-06-21 PH PH32439A patent/PH21319A/en unknown
- 1985-06-21 NO NO852514A patent/NO161620C/no unknown
- 1985-06-21 ES ES544417A patent/ES8604590A1/es not_active Expired
- 1985-06-21 KR KR1019850004411A patent/KR920007435B1/ko not_active Expired
- 1985-06-21 IE IE154585A patent/IE58432B1/en not_active IP Right Cessation
- 1985-06-21 IL IL75596A patent/IL75596A0/xx not_active IP Right Cessation
- 1985-06-21 CA CA000484743A patent/CA1241325A/en not_active Expired
- 1985-06-21 JP JP60135820A patent/JPH0694465B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US4714698A (en)	1987-12-22
KR860000287A (ko)	1986-01-27
FI852445L (fi)	1985-12-23
IE851545L (en)	1985-12-22
NO852514L (no)	1985-12-23
NO161620C (no)	1989-09-06
DE3573119D1 (en)	1989-10-26
ATE46511T1 (de)	1989-10-15
KR920007435B1 (ko)	1992-09-01
IE58432B1 (en)	1993-09-22
FI80455B (fi)	1990-02-28
JPS6115883A (ja)	1986-01-23
FI80455C (fi)	1990-06-11
AU579869B2 (en)	1988-12-15
PH21319A (en)	1987-09-28
NZ212515A (en)	1988-10-28
DK282285A (da)	1985-12-23
AU4396885A (en)	1986-01-02
JPH0694465B2 (ja)	1994-11-24
NO161620B (no)	1989-05-29
EP0167817A1 (de)	1986-01-15
CA1241325A (en)	1988-08-30
PT80670A (de)	1985-07-01
FI852445A0 (fi)	1985-06-20
DE3423092A1 (de)	1986-01-02
DK282285D0 (da)	1985-06-21
EP0167817B1 (de)	1989-09-20
GR851467B (es)	1985-11-25
ES8604590A1 (es)	1986-02-01
IL75596A0 (en)	1985-10-31
PT80670B (de)	1987-05-08
ZA854683B (en)	1987-02-25

Legal Events

Date	Code	Title	Description
1997-07-16	FD1A	Patent lapsed	Effective date: 19970612

Publication	Publication Date	Title
AU550774B2 (en)	1986-04-10	1-aryl-2-aminomethyl cyclopropane carboxylates
FI852445A0 (fi)	1985-06-20	Nya 8-alkyltio-2-piperazino- pyrimido/5,4-d/pyrimidiner, deras framstaellning och dessa foereningar innehaollande laekemedel.
ES508343A0 (es)	1982-11-01	"procedimiento para la preparacion de nuevas pirimido (5,4-d) pirimidinas trisustituidas".
AU655869B2 (en)	1995-01-12	An amphoteric tricyclic compound
ES8504180A1 (es)	1985-04-01	Procedimiento para preparar nuevos derivados de piperidina
ATE70838T1 (de)	1992-01-15	Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
ZA858030B (en)	1986-06-25	Thiadiazole derivatives active on the central nervous system,process for their preparation and pharmaceutical compositions in which they are present
ES539656A0 (es)	1986-09-01	Un procedimiento para la preparacion de nuevas 3-alcoxi-2-(n-pirrolidino)-n-piridiln-furilmetil propilaminas.
DE3764918D1 (de)	1990-10-18	2,6-piperazin-dion-derivate, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE75468T1 (de)	1992-05-15	Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
SE8804696D0 (sv)	1988-12-29	Dioxazocine derivatives their preparation and compositions containing them
ES2057282T3 (es)	1994-10-16	3-aminosidnoniminas substituidas, procedimiento para su obtencion y su empleo.
NZ195217A (en)	1983-11-18	Nb-quaternary derivatives of 10-bromosandwicine or 10-bromoisosandwicine
CA1270833C (en)	1990-06-26	2,5-PYRROLIDINEDIONE DERIVATIVES USEFUL AS ANTI-ARHYTMIZING AGENTS
ES8600206A1 (es)	1985-10-01	Procedimiento de preparacion de derivados alquilenodiaminos