ES545431A0 - Procedimiento de fabricacion de una molecula soportada - Google Patents

Procedimiento de fabricacion de una molecula soportada

Info

Publication number: ES545431A0
Authority: ES; Spain
Prior art keywords: group; fixed; base; oligo; polynucleotide
Prior art date: 1984-07-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES545431A

Other languages

English (en)

Other versions

ES8604259A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Centre National de la Recherche Scientifique CNRS

Institut Pasteur

Original Assignee

Centre National de la Recherche Scientifique CNRS

Institut Pasteur

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-12

Filing date

1985-07-11

Publication date

1986-02-01

1985-07-11 Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur filed Critical Centre National de la Recherche Scientifique CNRS

1986-02-01 Publication of ES545431A0 publication Critical patent/ES545431A0/es

1986-02-01 Publication of ES8604259A1 publication Critical patent/ES8604259A1/es

Status Expired legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 5
-1 methyl-5-uracil Chemical compound 0.000 abstract 4
108091033319 polynucleotide Proteins 0.000 abstract 4
239000002157 polynucleotide Substances 0.000 abstract 4
102000040430 polynucleotide Human genes 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
229910019142 PO4 Inorganic materials 0.000 abstract 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
229940104302 cytosine Drugs 0.000 abstract 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
239000010452 phosphate Substances 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
229940035893 uracil Drugs 0.000 abstract 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000295 complement effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
229940075420 xanthine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Immunology (AREA)
Saccharide Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Glass Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

ES545431A 1984-07-12 1985-07-11 Procedimiento de fabricacion de una molecula soportada Expired ES8604259A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8411101A FR2567523B1 (fr)	1984-07-12	1984-07-12	Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention

Publications (2)

Publication Number	Publication Date
ES545431A0 true ES545431A0 (es)	1986-02-01
ES8604259A1 ES8604259A1 (es)	1986-02-01

Family

ID=9306072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES545431A Expired ES8604259A1 (es)	1984-07-12	1985-07-11	Procedimiento de fabricacion de una molecula soportada

Country Status (9)

Country	Link
EP (1)	EP0174879B1 (es)
JP (1)	JPS61130305A (es)
AT (1)	ATE56724T1 (es)
DE (1)	DE3579776D1 (es)
DK (1)	DK318885A (es)
ES (1)	ES8604259A1 (es)
FR (1)	FR2567523B1 (es)
GR (1)	GR851739B (es)
PT (1)	PT80807B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734363A (en) *	1984-11-27	1988-03-29	Molecular Diagnostics, Inc.	Large scale production of DNA probes
US4818681A (en) *	1985-02-22	1989-04-04	Molecular Diagnostics, Inc.	Fast and specific immobilization of nucleic acids to solid supports
JPS622164A (ja) *	1985-06-25	1987-01-08	シスカ・ダイアグノステイツクス・インコ−ポレ−テツド	Ｎ４−（置換アミノ）シチジンを含む核酸プロ−ブ
US4868105A (en) *	1985-12-11	1989-09-19	Chiron Corporation	Solution phase nucleic acid sandwich assay
JPH084519B2 (ja) *	1987-12-25	1996-01-24	エフ・ホフマン―ラロシュアーゲー	ハイブリッド形成用担体およびその調整方法
US5744101A (en)	1989-06-07	1998-04-28	Affymax Technologies N.V.	Photolabile nucleoside protecting groups
US6955915B2 (en)	1989-06-07	2005-10-18	Affymetrix, Inc.	Apparatus comprising polymers
US6919211B1 (en)	1989-06-07	2005-07-19	Affymetrix, Inc.	Polypeptide arrays
US5215882A (en) *	1989-11-30	1993-06-01	Ortho Diagnostic Systems, Inc.	Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
GB0326073D0 (en)	2003-11-07	2003-12-10	Solexa Ltd	Improvements in or relating to polynucleotide arrays
FI3794012T3 (fi) *	2018-05-15	2024-01-08	Illumina Inc	Koostumuksia ja menetelmiä pintaan sitoutuneiden oligonukleotidien kemiallista pilkkomista ja suojauksen poistoa varten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2841414C2 (de) *	1978-09-22	1980-04-03	Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig	Verfahren zur Herstellung von an Makromoleküle gebundenen, ein Adeninringsystem enthaltenden Koenzymen
US4259232A (en) *	1979-10-23	1981-03-31	Miles Laboratories, Inc.	Flavin adenine dinucleotide-labeled protein and polypeptide conjugates
CA1219824A (en) *	1981-04-17	1987-03-31	David C. Ward	Modified nucleotides and methods of preparing and using same
IL70765A (en) *	1983-01-27	1988-07-31	Enzo Biochem Inc	Substrates containing non-radioactive chemically-labeled polynucleotides and methods using them
DE3481060D1 (de) *	1983-09-02	1990-02-22	Molecular Biosystems Inc	Oligonukleotid-polymer-tragsystem.

1984
- 1984-07-12 FR FR8411101A patent/FR2567523B1/fr not_active Expired
1985
- 1985-07-11 ES ES545431A patent/ES8604259A1/es not_active Expired
- 1985-07-12 DK DK318885A patent/DK318885A/da not_active Application Discontinuation
- 1985-07-12 PT PT80807A patent/PT80807B/pt unknown
- 1985-07-12 AT AT85401433T patent/ATE56724T1/de not_active IP Right Cessation
- 1985-07-12 JP JP60153941A patent/JPS61130305A/ja active Pending
- 1985-07-12 GR GR851739A patent/GR851739B/el unknown
- 1985-07-12 EP EP85401433A patent/EP0174879B1/fr not_active Expired - Lifetime
- 1985-07-12 DE DE8585401433T patent/DE3579776D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2567523A1 (fr)	1986-01-17
DE3579776D1 (de)	1990-10-25
ATE56724T1 (de)	1990-10-15
PT80807A (fr)	1985-08-01
GR851739B (es)	1985-11-26
PT80807B (fr)	1987-03-26
FR2567523B1 (fr)	1987-11-13
JPS61130305A (ja)	1986-06-18
DK318885A (da)	1986-01-13
EP0174879A1 (fr)	1986-03-19
ES8604259A1 (es)	1986-02-01
DK318885D0 (da)	1985-07-12
EP0174879B1 (fr)	1990-09-19

Legal Events

Date	Code	Title	Description
1996-06-01	MM4A	Patent lapsed	Effective date: 19960401

Publication	Publication Date	Title
ES545431A0 (es)	1986-02-01	Procedimiento de fabricacion de una molecula soportada
DK0679657T3 (da)	2003-10-27	Nukleosider og oligonukleotider med 2'-ethergrupper
BG95575A (bg)	1993-12-24	3'-(2')-амино-и тиолмодифицирани, свързани с флуоресциращо багрило нуклеозиди,нуклеотиди и олигонуклеотиди и метод за тяхното получаване и приложението им
Dempcy et al.	1995	Synthesis of the polycation thymidyl DNG, its fidelity in binding polyanionic DNA/RNA, and the stability and nature of the hybrid complexes
DE59102512D1 (de)	1994-09-15	2'-o-alkylnukleotide sowie polymere, die solche nukleotide enthalten.
RU2227143C2 (ru)	2004-04-20	Новые бициклонуклеозидные аналоги
CA2124814C (en)	2000-10-24	2'-deoxy-isoquanosines, isosteric analogues and isoquanosine derivatives as well as their use
NZ507913A (en)	2003-02-28	Novel nucleosides having bicyclic sugar moiety
DE3854297D1 (de)	1995-09-14	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
DE552178T1 (de)	1994-02-03	Abgeänderte ribozyme.
DE3670293D1 (de)	1990-05-17	Adenosin-nukleosid-derivate, ihre herstellung und biologische verwendung.
EP0977767A4 (en)	2003-04-23	AMINOOXY MODIFIED OLIGONUCLEOTIDES
DK0626387T3 (da)	1999-09-27	Nukleosider og oligonukleotider med 2'-ethergrupper
ATE432284T1 (de)	2009-06-15	Einen starren linker enthaltende nukleotide
IL97804A0 (en)	1992-06-21	Oligonucleotide analogs
KR920701230A (ko)	1992-08-11	엑소뉴클레아제-내성 올리고뉴클레오티드 및 그 제조방법
KR890008161A (ko)	1989-07-10	2',3'-디데옥시-2'-플루오로뉴클레오사이드류
WO2000030629A3 (en)	2001-06-07	Method of promoting cervical and vaginal secretions
TW341574B (en)	1998-10-01	METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.
IL98702A0 (en)	1992-07-15	9-purinyl phosphonic acid derivatives
ES8707971A1 (es)	1987-09-01	Un metodo para producir un nucleosido de citosina
EP0314500A3 (en)	1989-07-26	Diagnostic probe for diabetes type 1 predisposition
DE69533856D1 (de)	2005-01-20	L-pyranosyl-nukleoside
Naval et al.	2002	2-Amino-α-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-Oligodeoxynucleotides with RNA target
EP0353268A4 (en)	1990-05-14	ANTI-TUMOR PURINES OF 6-SULFENAMIDE, 6-SULFINAMIDE AND 6-SULFONAMIDE, PURINE NUCLEOSIDES, PURINE NUCLEOTIDES AND RELATED COMPOUNDS.