DK318885A - Polynukleotider, der er bundet kovalent til en fast baerer, fremgangsmaade til deres fremstilling samt anvendelsen heraf - Google Patents

Polynukleotider, der er bundet kovalent til en fast baerer, fremgangsmaade til deres fremstilling samt anvendelsen heraf Download PDF

Info

Publication number: DK318885A
Authority: DK; Denmark
Prior art keywords: fixed; group; base; oligo; polynucleotide
Prior art date: 1984-07-12

Application number

DK318885A

Other languages

English (en)

Other versions

DK318885D0 (da

Inventor

Tam Huynh-Dinh

Sylvie Pochet

Jean Igolen

Original Assignee

Pasteur Institut

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-12

Filing date

1985-07-12

Publication date

1986-01-13

1985-07-12 Application filed by Pasteur Institut, Centre Nat Rech Scient filed Critical Pasteur Institut

1985-07-12 Publication of DK318885D0 publication Critical patent/DK318885D0/da

1986-01-13 Publication of DK318885A publication Critical patent/DK318885A/da

Links

108091033319 polynucleotide Proteins 0.000 title abstract 5
239000002157 polynucleotide Substances 0.000 title abstract 5
102000040430 polynucleotide Human genes 0.000 title abstract 5
108091034117 Oligonucleotide Proteins 0.000 abstract 5
-1 methyl-5-uracil Chemical compound 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
229910019142 PO4 Inorganic materials 0.000 abstract 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
229940104302 cytosine Drugs 0.000 abstract 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
239000010452 phosphate Substances 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
229940035893 uracil Drugs 0.000 abstract 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
229930024421 Adenine Natural products 0.000 abstract 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
229960000643 adenine Drugs 0.000 abstract 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000295 complement effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
229940075420 xanthine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Immunology (AREA)
Saccharide Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Glass Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK318885A 1984-07-12 1985-07-12 Polynukleotider, der er bundet kovalent til en fast baerer, fremgangsmaade til deres fremstilling samt anvendelsen heraf DK318885A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8411101A FR2567523B1 (fr)	1984-07-12	1984-07-12	Polynucleotides lies de facon covalente a un support solide, et procede pour leur obtention

Publications (2)

Publication Number	Publication Date
DK318885D0 DK318885D0 (da)	1985-07-12
DK318885A true DK318885A (da)	1986-01-13

Family

ID=9306072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK318885A DK318885A (da)	1984-07-12	1985-07-12	Polynukleotider, der er bundet kovalent til en fast baerer, fremgangsmaade til deres fremstilling samt anvendelsen heraf

Country Status (9)

Country	Link
EP (1)	EP0174879B1 (da)
JP (1)	JPS61130305A (da)
AT (1)	ATE56724T1 (da)
DE (1)	DE3579776D1 (da)
DK (1)	DK318885A (da)
ES (1)	ES8604259A1 (da)
FR (1)	FR2567523B1 (da)
GR (1)	GR851739B (da)
PT (1)	PT80807B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734363A (en) *	1984-11-27	1988-03-29	Molecular Diagnostics, Inc.	Large scale production of DNA probes
US4818681A (en) *	1985-02-22	1989-04-04	Molecular Diagnostics, Inc.	Fast and specific immobilization of nucleic acids to solid supports
EP0209996A3 (en) *	1985-06-25	1987-09-02	Siska Diagnostics,Inc.	Nucleic acid probes comprising n4 -(substituted amino)cytidines
US4868105A (en) *	1985-12-11	1989-09-19	Chiron Corporation	Solution phase nucleic acid sandwich assay
JPH084519B2 (ja) *	1987-12-25	1996-01-24	エフ・ホフマン―ラロシュアーゲー	ハイブリッド形成用担体およびその調整方法
US5744101A (en)	1989-06-07	1998-04-28	Affymax Technologies N.V.	Photolabile nucleoside protecting groups
US6955915B2 (en)	1989-06-07	2005-10-18	Affymetrix, Inc.	Apparatus comprising polymers
US6919211B1 (en)	1989-06-07	2005-07-19	Affymetrix, Inc.	Polypeptide arrays
US5215882A (en) *	1989-11-30	1993-06-01	Ortho Diagnostic Systems, Inc.	Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
GB0326073D0 (en)	2003-11-07	2003-12-10	Solexa Ltd	Improvements in or relating to polynucleotide arrays
KR20240027158A (ko) *	2018-05-15	2024-02-29	일루미나, 인코포레이티드	표면-결합 올리고뉴클레오타이드의 화학적 절단 및 탈보호를 위한 조성물 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2841414C2 (de) *	1978-09-22	1980-04-03	Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig	Verfahren zur Herstellung von an Makromoleküle gebundenen, ein Adeninringsystem enthaltenden Koenzymen
US4259232A (en) *	1979-10-23	1981-03-31	Miles Laboratories, Inc.	Flavin adenine dinucleotide-labeled protein and polypeptide conjugates
CA1219824A (en) *	1981-04-17	1987-03-31	David C. Ward	Modified nucleotides and methods of preparing and using same
CA1309672C (en) *	1983-01-27	1992-11-03	Jannis G. Stavrianopoulos	Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
WO1985001051A1 (en) *	1983-09-02	1985-03-14	Molecular Biosystems, Inc.	Oligonucleotide polymeric support system

1984
- 1984-07-12 FR FR8411101A patent/FR2567523B1/fr not_active Expired
1985
- 1985-07-11 ES ES545431A patent/ES8604259A1/es not_active Expired
- 1985-07-12 DK DK318885A patent/DK318885A/da not_active Application Discontinuation
- 1985-07-12 JP JP60153941A patent/JPS61130305A/ja active Pending
- 1985-07-12 AT AT85401433T patent/ATE56724T1/de not_active IP Right Cessation
- 1985-07-12 EP EP85401433A patent/EP0174879B1/fr not_active Expired - Lifetime
- 1985-07-12 GR GR851739A patent/GR851739B/el unknown
- 1985-07-12 DE DE8585401433T patent/DE3579776D1/de not_active Expired - Lifetime
- 1985-07-12 PT PT80807A patent/PT80807B/pt unknown

Also Published As

Publication number	Publication date
ATE56724T1 (de)	1990-10-15
DE3579776D1 (de)	1990-10-25
ES545431A0 (es)	1986-02-01
GR851739B (da)	1985-11-26
PT80807A (fr)	1985-08-01
EP0174879A1 (fr)	1986-03-19
FR2567523B1 (fr)	1987-11-13
ES8604259A1 (es)	1986-02-01
EP0174879B1 (fr)	1990-09-19
PT80807B (fr)	1987-03-26
DK318885D0 (da)	1985-07-12
FR2567523A1 (fr)	1986-01-17
JPS61130305A (ja)	1986-06-18

Legal Events

Date	Code	Title	Description
1992-03-30	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK318885D0 (da)	1985-07-12	Polynukleotider, der er bundet kovalent til en fast baerer, fremgangsmaade til deres fremstilling samt anvendelsen heraf
DK0679657T3 (da)	2003-10-27	Nukleosider og oligonukleotider med 2'-ethergrupper
RU2227143C2 (ru)	2004-04-20	Новые бициклонуклеозидные аналоги
Dempcy et al.	1995	Synthesis of the polycation thymidyl DNG, its fidelity in binding polyanionic DNA/RNA, and the stability and nature of the hybrid complexes
CA2080231A1 (en)	1991-10-10	2'-o-alkylnucleotides as well as polymers which contain such nucleotides
IL100298A (en)	1997-03-18	3(-(2()-amino- or thiol- modified, fluorescent dye- coupled nucleosides, nucleotides and oligonucleotides, and a process for the preparation and the use thereof
EP0637314B1 (en)	1998-06-24	N-acylated 2'-deoxycytidines useful in oligonucleotide synthesis
CA2124814C (en)	2000-10-24	2'-deoxy-isoquanosines, isosteric analogues and isoquanosine derivatives as well as their use
NZ507913A (en)	2003-02-28	Novel nucleosides having bicyclic sugar moiety
DE552178T1 (de)	1994-02-03	Abgeänderte ribozyme.
EP0977767A4 (en)	2003-04-23	AMINOOXY MODIFIED OLIGONUCLEOTIDES
ATE126060T1 (de)	1995-08-15	Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
IL97804A0 (en)	1992-06-21	Oligonucleotide analogs
KR890008161A (ko)	1989-07-10	2',3'-디데옥시-2'-플루오로뉴클레오사이드류
EP0314500A3 (en)	1989-07-26	Diagnostic probe for diabetes type 1 predisposition
AU2890497A (en)	1997-12-09	Nucleoside derivatives with photolabile protective groups
EP0391411A3 (en)	1991-04-10	3'-substituted methyl nucleosides as antiviral agents
DK0862628T3 (da)	2004-11-01	Receptor og nukleinsyremolekyle, der koder for receptoren
ATE284894T1 (de)	2005-01-15	L-pyranosyl-nukleoside
Naval et al.	2002	2-Amino-α-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-Oligodeoxynucleotides with RNA target
De Clercq	1987	Antiviral nucleoside analogs.
EP0353268A4 (en)	1990-05-14	ANTI-TUMOR PURINES OF 6-SULFENAMIDE, 6-SULFINAMIDE AND 6-SULFONAMIDE, PURINE NUCLEOSIDES, PURINE NUCLEOTIDES AND RELATED COMPOUNDS.
EP0320807A3 (en)	1991-05-08	Novel polynucleotide analogs, methods for inhibiting nucleic acid polymerases and methods for inducing synthesis of interferon
Repkova et al.	2002	Oligoribonucleotides containing an aminoalkyl group at the N (4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers
WO1994001445B1 (en)	1994-04-14	Base-protected nucleotide analogs with protected thiol groups