ES546799A0 - Procedimiento para la obtencion de formulaciones medicionales solidas de nitrendipina cristalina. - Google Patents

Procedimiento para la obtencion de formulaciones medicionales solidas de nitrendipina cristalina.

Info

Publication number: ES546799A0
Authority: ES; Spain
Prior art keywords: weight; nitrendipine; crystal; procedure; parts
Prior art date: 1984-09-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES546799A

Other languages

English (en)

Other versions

ES8800153A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-09-11

Filing date

1985-09-09

Publication date

1987-10-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6245068&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES546799(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-09-09 Application filed by Bayer AG filed Critical Bayer AG

1987-10-16 Publication of ES8800153A1 publication Critical patent/ES8800153A1/es

1987-10-16 Publication of ES546799A0 publication Critical patent/ES546799A0/es

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 3
229960005425 nitrendipine Drugs 0.000 title abstract 2
239000007787 solid Substances 0.000 title abstract 2
PVHUJELLJLJGLN-UHFFFAOYSA-N nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-UHFFFAOYSA-N 0.000 title 1
238000009472 formulation Methods 0.000 abstract 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
PVHUJELLJLJGLN-INIZCTEOSA-N (S)-nitrendipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC([N+]([O-])=O)=C1 PVHUJELLJLJGLN-INIZCTEOSA-N 0.000 abstract 1
229920002261 Corn starch Polymers 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
239000004141 Sodium laurylsulphate Substances 0.000 abstract 1
239000008120 corn starch Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
235000019359 magnesium stearate Nutrition 0.000 abstract 1
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
239000008108 microcrystalline cellulose Substances 0.000 abstract 1
229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
235000019333 sodium laurylsulphate Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)

ES546799A 1984-09-11 1985-09-09 Procedimiento para la obtencion de formulaciones medicionales solidas de nitrendipina cristalina. Expired ES8800153A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843433239 DE3433239A1 (de)	1984-09-11	1984-09-11	Feste arzneizubereitung enthaltend nitrendipin und verfahren zu ihrer herstellung

Publications (2)

Publication Number	Publication Date
ES8800153A1 ES8800153A1 (es)	1987-10-16
ES546799A0 true ES546799A0 (es)	1987-10-16

Family

ID=6245068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES546799A Expired ES8800153A1 (es)	1984-09-11	1985-09-09	Procedimiento para la obtencion de formulaciones medicionales solidas de nitrendipina cristalina.

Country Status (13)

Country	Link
US (1)	US4724141A (es)
EP (1)	EP0176773B1 (es)
JP (1)	JPH0761960B2 (es)
KR (1)	KR920006909B1 (es)
AT (1)	ATE48943T1 (es)
AU (1)	AU578114B2 (es)
CA (1)	CA1261271A (es)
DE (2)	DE3433239A1 (es)
DK (1)	DK411485A (es)
ES (1)	ES8800153A1 (es)
GR (1)	GR852176B (es)
IL (1)	IL76332A0 (es)
ZA (1)	ZA856916B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1178511B (it) *	1984-09-14	1987-09-09	Pharmatec Spa	Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
US4771057A (en) *	1986-02-03	1988-09-13	University Of Alberta	Reduced pyridyl derivatives with cardiovascular regulating properties
DE3639073A1 (de) *	1986-11-14	1988-05-26	Klinge Co Chem Pharm Fab	Feste arzneizubereitungen und verfahren zu ihrer herstellung
US5190962A (en) *	1990-03-13	1993-03-02	Sepracor, Inc.	Treating hypertension
US5571827A (en) *	1990-03-13	1996-11-05	Sepracor Inc.	Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
FR2661611B1 (fr) *	1990-05-04	1994-11-18	Theramex	Nouvelles compositions pharmaceutiques a base de polycarbophil et leur procede d'obtention.
SI9300504A (en) *	1993-09-28	1995-04-30	Krka	Process for preparation solid dispersions and deposits of calcium antagonist dihidropyrimidine derivates and pharmaceutical compositions comprising the same
JP2713549B2 (ja) *	1994-05-17	1998-02-16	財団法人工業技術研究院	防湿性漢方製剤
JP2656727B2 (ja) *	1994-05-17	1997-09-24	財団法人工業技術研究院	防湿性漢方顆粒製剤
CN1158075C (zh) *	1998-12-01	2004-07-21	诺沃挪第克公司	新药物组合物及其制备方法
EG23951A (en) *	1999-03-25	2008-01-29	Otsuka Pharma Co Ltd	Cilostazol preparation
JP4748839B2 (ja) *	1999-03-25	2011-08-17	大塚製薬株式会社	シロスタゾール製剤
CA2430288C (en) *	2000-12-01	2009-03-10	Kyowa Hakko Kogyo Co., Ltd.	A composition improved in the solubility or oral absorbability
FR2827517B1 (fr)	2001-07-23	2003-10-24	Bioalliance Pharma	Systemes therapeutiques bioadhesifs a liberation prolongee
DE10355461A1 (de)	2003-11-27	2005-06-23	Bayer Healthcare Ag	Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
EP1837020A1 (en)	2006-03-24	2007-09-26	Bioalliance Pharma	Mucosal bioadhesive slow release carrier for delivering active principles
EP3002005A1 (en) *	2014-09-30	2016-04-06	Molkerei Meggle Wasserburg GmbH & Co. Kg	Direct compression excipient based on lactose, cellulose and starch
US11883404B2 (en)	2016-03-04	2024-01-30	Taiho Pharmaceuticals Co., Ltd.	Preparation and composition for treatment of malignant tumors
EP3424505A4 (en)	2016-03-04	2019-10-16	Taiho Pharmaceutical Co., Ltd.	PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS
EP4470621A3 (en)	2018-03-19	2025-05-07	Taiho Pharmaceutical Co., Ltd.	Use of sodium alkyl sulfate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2837477A1 (de) *	1978-08-28	1980-03-13	Bayer Ag	Sila-substituierte 1,4-dihydropyridin- derivate
JPS5547615A (en) *	1978-09-29	1980-04-04	Taiyo Yakuhin Kogyo Kk	Stable solid drug of nifedipine
JPS56110612A (en) *	1980-02-08	1981-09-01	Yamanouchi Pharmaceut Co Ltd	Readily disintegrable and absorbable compression molded article of slightly soluble drug
DE3142853A1 (de) *	1981-10-29	1983-05-11	Bayer Ag, 5090 Leverkusen	Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung
DE3212736A1 (de) *	1982-04-06	1983-10-13	Bayer Ag, 5090 Leverkusen	Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3307422A1 (de) *	1983-03-03	1984-09-06	Bayer Ag, 5090 Leverkusen	Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen

1984
- 1984-09-11 DE DE19843433239 patent/DE3433239A1/de not_active Withdrawn
1985
- 1985-08-30 DE DE8585110921T patent/DE3574933D1/de not_active Expired - Lifetime
- 1985-08-30 AT AT85110921T patent/ATE48943T1/de not_active IP Right Cessation
- 1985-08-30 EP EP85110921A patent/EP0176773B1/de not_active Expired
- 1985-09-05 US US06/772,828 patent/US4724141A/en not_active Expired - Lifetime
- 1985-09-09 IL IL76332A patent/IL76332A0/xx not_active IP Right Cessation
- 1985-09-09 JP JP60197860A patent/JPH0761960B2/ja not_active Expired - Fee Related
- 1985-09-09 ES ES546799A patent/ES8800153A1/es not_active Expired
- 1985-09-09 CA CA000490274A patent/CA1261271A/en not_active Expired
- 1985-09-09 GR GR852176A patent/GR852176B/el unknown
- 1985-09-10 AU AU47335/85A patent/AU578114B2/en not_active Ceased
- 1985-09-10 ZA ZA856916A patent/ZA856916B/xx unknown
- 1985-09-10 KR KR1019850006587A patent/KR920006909B1/ko not_active Expired
- 1985-09-10 DK DK411485A patent/DK411485A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA1261271A (en)	1989-09-26
JPH0761960B2 (ja)	1995-07-05
AU578114B2 (en)	1988-10-13
DE3574933D1 (de)	1990-02-01
DK411485A (da)	1986-03-12
EP0176773B1 (de)	1989-12-27
US4724141A (en)	1988-02-09
ES8800153A1 (es)	1987-10-16
AU4733585A (en)	1986-03-20
ZA856916B (en)	1986-04-30
JPS6168431A (ja)	1986-04-08
KR860002270A (ko)	1986-04-24
GR852176B (es)	1986-01-10
IL76332A0 (en)	1986-01-31
DE3433239A1 (de)	1986-03-20
KR920006909B1 (ko)	1992-08-22
EP0176773A1 (de)	1986-04-09
DK411485D0 (da)	1985-09-10
ATE48943T1 (de)	1990-01-15

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Legal Events

Date	Code	Title	Description
1997-05-16	FD1A	Patent lapsed	Effective date: 19970401