ES552898A0 - Procedimiento para producir heparan sulfato natural y dermatan sulfato en forma sustancialmente pura - Google Patents

Procedimiento para producir heparan sulfato natural y dermatan sulfato en forma sustancialmente pura

Info

Publication number: ES552898A0
Authority: ES; Spain
Prior art keywords: sulphate; heparan; substantially pure; pure form; producing natural
Prior art date: 1985-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES86552898A

Other languages

English (en)

Other versions

ES8705894A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mediolanum Farmaceutici SpA

Original Assignee

Mediolanum Farmaceutici SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-13

Filing date

1986-03-12

Publication date

1987-05-16

1986-03-12 Application filed by Mediolanum Farmaceutici SpA filed Critical Mediolanum Farmaceutici SpA

1987-05-16 Publication of ES8705894A1 publication Critical patent/ES8705894A1/es

1987-05-16 Publication of ES552898A0 publication Critical patent/ES552898A0/es

Status Expired legal-status Critical Current

Links

229920002971 Heparan sulfate Polymers 0.000 title abstract 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229910021653 sulphate ion Inorganic materials 0.000 title abstract 2
FPJHWYCPAOPVIV-VOZMEZHOSA-N (2R,3S,4R,5R,6R)-6-[(2R,3R,4R,5R,6R)-5-acetamido-2-(hydroxymethyl)-6-methoxy-3-sulfooxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CO[C@@H]1O[C@H](CO)[C@H](OS(O)(=O)=O)[C@H](O[C@@H]2O[C@H]([C@@H](OC)[C@H](O)[C@H]2O)C(O)=O)[C@H]1NC(C)=O FPJHWYCPAOPVIV-VOZMEZHOSA-N 0.000 abstract 2
229920000045 Dermatan sulfate Polymers 0.000 abstract 2
102000016611 Proteoglycans Human genes 0.000 abstract 2
108010067787 Proteoglycans Proteins 0.000 abstract 2
230000003480 fibrinolytic effect Effects 0.000 abstract 2
102000004411 Antithrombin III Human genes 0.000 abstract 1
108090000935 Antithrombin III Proteins 0.000 abstract 1
108010074860 Factor Xa Proteins 0.000 abstract 1
230000003213 activating effect Effects 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
229960005348 antithrombin iii Drugs 0.000 abstract 1
210000000709 aorta Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
210000004165 myocardium Anatomy 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
108020001775 protein parts Proteins 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0066—Isolation or extraction of proteoglycans from organs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Dermatology (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pyrane Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

ES552898A 1985-03-13 1986-03-12 Procedimiento para producir heparan sulfato natural y dermatan sulfato en forma sustancialmente pura Expired ES8705894A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8519885A IT1208509B (it)	1985-03-13	1985-03-13	Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Publications (2)

Publication Number	Publication Date
ES8705894A1 ES8705894A1 (es)	1987-05-16
ES552898A0 true ES552898A0 (es)	1987-05-16

Family

ID=11162062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES552898A Expired ES8705894A1 (es)	1985-03-13	1986-03-12	Procedimiento para producir heparan sulfato natural y dermatan sulfato en forma sustancialmente pura

Country Status (20)

Country	Link
US (1)	US4783447A (es)
EP (1)	EP0199033B1 (es)
JP (1)	JPS61218601A (es)
KR (1)	KR910006809B1 (es)
AT (1)	ATE99702T1 (es)
AU (1)	AU582221B2 (es)
CA (1)	CA1286286C (es)
DE (1)	DE3689493T2 (es)
DK (1)	DK113886A (es)
ES (1)	ES8705894A1 (es)
FI (1)	FI82700C (es)
GR (1)	GR860677B (es)
IN (1)	IN163616B (es)
IT (1)	IT1208509B (es)
NO (1)	NO166187C (es)
NZ (1)	NZ215435A (es)
PH (2)	PH22370A (es)
PT (1)	PT82198B (es)
YU (1)	YU46303B (es)
ZA (1)	ZA861855B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1189085B (it) *	1986-03-25	1988-01-28	Mediolanum Farmaceutici Srl	Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono
US5707604A (en) *	1986-11-18	1998-01-13	Access Pharmaceuticals, Inc.	Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
DE3639561A1 (de) *	1986-11-20	1988-06-01	Baumann Hanno	Verfahren zur herstellung von nicht-thrombogenen substraten
IT1232939B (it) *	1987-11-06	1992-03-10	Opocrin Spa	Eparan solfato caratterizzato da elevata attivita' antitrombotica, elevata biodisponibilita', assenza di attivita' anticoagulante; suo processo di estrazione da organi e da tessuti e relative composizioni farmaceutiche
HU208029B (en) *	1988-06-03	1993-07-28	Italfarmaco Spa	Process for producing glycose-amino-glycane salts and pharmaceutical compositions containing them
EP0421508B1 (en) *	1989-10-04	1993-12-15	Akzo Nobel N.V.	Sulphated glycosaminoglycuronan with antithrombotic activity
AU6872691A (en) *	1989-10-27	1991-05-31	Case Western Reserve University	Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
IT1240615B (it) *	1990-04-03	1993-12-17	Mediolanum Farmaceutici Spa	Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
WO1991015217A1 (en) *	1990-04-06	1991-10-17	Washington University	Anticoagulant oligosaccharides
US5705178A (en) *	1991-05-31	1998-01-06	Gliatech, Inc.	Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) *	1991-05-31	1997-02-25	Gliatech, Inc.	Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
FR2691066B1 (fr) *	1992-05-15	1995-06-09	Sanofi Elf	Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
IT1256236B (it) *	1992-12-23	1995-11-29	Mediolanum Farmaceutici Srl	Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
DE69429576T2 (de) *	1993-09-30	2002-08-22	Seikagaku Kogyo K.K., Tokio/Tokyo	Dermatansulfatezusammensetzung als antithromotisches mittel
US6106866A (en) *	1995-07-31	2000-08-22	Access Pharmaceuticals, Inc.	In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
IT1296581B1 (it) *	1997-11-28	1999-07-14	Istituto Scient Di Chimica E B	Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
JP2003504428A (ja) *	1999-06-30	2003-02-04	ハミルトンシビックホスピタルズリサーチディベロップメントインコーポレイテッド	クロット関連凝固因子を阻害するヘパリン組成物
AU2001291549A1 (en) *	2000-09-08	2002-03-22	Hamilton Civic Hospitals Research Development Inc.	Antithrombotic compositions
CN107098989A (zh) *	2017-04-27	2017-08-29	甘肃省金羚集团药业有限公司	一种肝素钠的制备方法
CN114478832B (zh) *	2022-02-14	2023-03-03	河北常山生化药业股份有限公司	从肝素钠副产物中提纯四种多糖类产品的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3179566A (en) *	1963-05-16	1965-04-20	Canada Packers Ltd	Purification of heparin
JPS5318520B2 (es) *	1972-07-05	1978-06-15
AR207237A1 (es) *	1974-02-25	1976-09-22	Thomas A	Procedimiento para obtener extractos biologicos estables liofilizados solubles constituidos por complejos proteicos termorresistentes
US4243582A (en) *	1979-04-26	1981-01-06	Monsanto Company	Novel glycoproteins from bovine cartilage
JPS58171403A (ja) *	1982-04-01	1983-10-08	Eisai Co Ltd	ヘパラン硫酸の精製法
IT1189298B (it) *	1982-06-18	1988-02-04	Manetti & Roberts Italo Brit	Procedimento per produrre i glicosa minoglicani dermatansolfato ed eparan-solfato sostanzialmente puri e loro impiego farmaceutico
FR2555993B1 (fr) *	1983-12-06	1986-11-07	Anic Spa	Chitosanes 6-sulfates et procede pour leur preparation
IT1195497B (it) *	1983-03-08	1988-10-19	Opocrin Spa	Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
IT1163772B (it) *	1983-07-13	1987-04-08	Baldacci Lab Spa	Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche

1985
- 1985-03-13 IT IT8519885A patent/IT1208509B/it active
1986
- 1986-03-06 EP EP86102963A patent/EP0199033B1/en not_active Expired - Lifetime
- 1986-03-06 DE DE86102963T patent/DE3689493T2/de not_active Expired - Fee Related
- 1986-03-06 AT AT86102963T patent/ATE99702T1/de not_active IP Right Cessation
- 1986-03-10 US US06/838,133 patent/US4783447A/en not_active Expired - Fee Related
- 1986-03-11 NZ NZ215435A patent/NZ215435A/xx unknown
- 1986-03-12 ES ES552898A patent/ES8705894A1/es not_active Expired
- 1986-03-12 GR GR860677A patent/GR860677B/el unknown
- 1986-03-12 PH PH33516A patent/PH22370A/en unknown
- 1986-03-12 ZA ZA861855A patent/ZA861855B/xx unknown
- 1986-03-12 FI FI861020A patent/FI82700C/fi not_active IP Right Cessation
- 1986-03-12 IN IN184/CAL/86A patent/IN163616B/en unknown
- 1986-03-12 NO NO860940A patent/NO166187C/no unknown
- 1986-03-12 CA CA000503943A patent/CA1286286C/en not_active Expired - Lifetime
- 1986-03-12 DK DK113886A patent/DK113886A/da not_active Application Discontinuation
- 1986-03-13 KR KR1019860001805A patent/KR910006809B1/ko not_active Expired
- 1986-03-13 AU AU54727/86A patent/AU582221B2/en not_active Ceased
- 1986-03-13 PT PT82198A patent/PT82198B/pt unknown
- 1986-03-13 YU YU37586A patent/YU46303B/sh unknown
- 1986-03-13 JP JP61053838A patent/JPS61218601A/ja active Granted
1987
- 1987-06-10 PH PH35381A patent/PH25136A/en unknown

Also Published As

Publication number	Publication date
EP0199033B1 (en)	1994-01-05
NZ215435A (en)	1989-01-06
JPH0238601B2 (es)	1990-08-31
IT8519885A0 (it)	1985-03-13
YU46303B (sh)	1993-05-28
EP0199033A2 (en)	1986-10-29
YU37586A (en)	1988-04-30
PT82198A (en)	1986-04-01
IT1208509B (it)	1989-07-10
PH25136A (en)	1991-02-19
FI861020A0 (fi)	1986-03-12
FI82700B (fi)	1990-12-31
AU582221B2 (en)	1989-03-16
KR860007278A (ko)	1986-10-10
ES8705894A1 (es)	1987-05-16
DK113886A (da)	1986-09-14
FI861020A7 (fi)	1986-09-14
ATE99702T1 (de)	1994-01-15
NO166187B (no)	1991-03-04
DE3689493T2 (de)	1994-04-28
CA1286286C (en)	1991-07-16
PT82198B (pt)	1988-02-17
JPS61218601A (ja)	1986-09-29
NO166187C (no)	1991-06-12
IN163616B (es)	1988-10-15
GR860677B (en)	1986-07-14
PH22370A (en)	1988-08-12
US4783447A (en)	1988-11-08
KR910006809B1 (ko)	1991-09-02
DE3689493D1 (de)	1994-02-17
FI82700C (fi)	1991-04-10
EP0199033A3 (en)	1988-03-30
NO860940L (no)	1986-09-15
DK113886D0 (da)	1986-03-12
ZA861855B (en)	1986-10-29
AU5472786A (en)	1986-09-18

Legal Events

Date	Code	Title	Description
1997-08-01	FD1A	Patent lapsed	Effective date: 19970612

Publication	Publication Date	Title
FI861020A0 (fi)	1986-03-12	Foerfarande foer framstaellning av naturligt heparansulfat och dermatansulfat i vaesentligen ren form.
DE69636813D1 (de)	2007-02-15	Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion
AU570366B2 (en)	1988-03-10	Esterified oligosaccharides
DE69217491D1 (de)	1997-03-27	Verfahren zur enzymatischen herstellung von alpha-sialylierten oligosaccharid-glykosiden
KR970070247A (ko)	1997-11-07	미세 패턴용 전해 구리 호일 및 그의 제조 방법
NO863135L (no)	1987-02-09	Polysakkaridpolymer fremstilt ved hjelp av en mikroorganisme av slekten xanthomonas.
DE3581969D1 (de)	1991-04-11	Erzeugung von synthesegas unter verhinderung von abscheidungen in den austragsleitungen.
NZ333925A (en)	2000-07-28	Use of heparin or heparan sulphate in combination with chitosan for the prevention or treatment of infections caused by herpes virus
ES2048974T3 (es)	1994-04-01	Aparato para producir continuamente agua electrolizada.
AU7040598A (en)	1998-10-20	Glycosaminoglycans having high antithrombotic activity
BR0010621A (pt)	2002-04-02	Produção de carboidratos complexos
IT1251182B (it)	1995-05-04	Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche.
ATE332706T1 (de)	2006-08-15	Verwendung von hyaluronidase zur herstellung eines arzneimittels zur behandlung von entzündungen
ATE261438T1 (de)	2004-03-15	Produkte für körperhygiene basierend auf lapacho extrakte enthaltend quercetin, deren herstellung und verwendung
WO2000017176A3 (de)	2001-10-11	Benzolylguanidin-abkömmlinge mit vorteilhaften eigenschaften, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von arzneimiteln
HUT53912A (en)	1990-12-28	New process for producing disaccharid -octasulfate- aluminium-complexes and their hydrates
Moore	1990	An abstract submitted in partial fulfillment of the requirements for the degree of Master of Music in
FI932524A0 (fi)	1993-06-02	Modifierade Trichoderma-stammar, enzympreparat producerat med dem och anvaendning av enzympreparat i hydrolys av biomassa
BR7703168U (pt)	2000-03-08	Móveis de papel reciclado.
ITVI930007A1 (it)	1994-07-28	Procedimento per ottenere un tubetto in metallo prezioso, aperto lungo una generatrice e riempito di un metallo diverso che permette qualsia-
ES1016950U (es)	1991-12-01	Modulo integrado de conexion de servicios para viviendas unifamiliares.
ES293667U (es)	1986-08-16	Estructura espacial para formacion de cupulas y bovedas ligeras medias y pesadas
KR880010041A (ko)	1988-10-06	대전 방지된 폴리에스터의 제조방법
JPS6448822A (en)	1989-02-23	Production of modified polyester
IT8900650A0 (it)	1989-10-27	Processo industriale per la produzione di pannelli rivestiti in laminato plastico post-formabile con bordi smussati o bombati