ES555837A0 - Un procedimiento para producir sulfatos de esteres de monoalquilo de glutationa - Google Patents
Un procedimiento para producir sulfatos de esteres de monoalquilo de glutationaInfo
- Publication number
- ES555837A0 ES555837A0 ES555837A ES555837A ES555837A0 ES 555837 A0 ES555837 A0 ES 555837A0 ES 555837 A ES555837 A ES 555837A ES 555837 A ES555837 A ES 555837A ES 555837 A0 ES555837 A0 ES 555837A0
- Authority
- ES
- Spain
- Prior art keywords
- glutathione
- sulfates
- monoalkyl esters
- glutationa
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 6
- 108010024636 Glutathione Proteins 0.000 abstract 3
- 229960003180 glutathione Drugs 0.000 abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000011033 desalting Methods 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- -1 glutathione monoester sulfates Chemical class 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000167 toxic agent Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12393085 | 1985-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES555837A0 true ES555837A0 (es) | 1987-07-16 |
| ES8707261A1 ES8707261A1 (es) | 1987-07-16 |
Family
ID=14872863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES555837A Expired ES8707261A1 (es) | 1985-06-07 | 1986-06-06 | Un procedimiento para producir sulfatos de esteres de monoalquilo de glutationa |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4709013A (es) |
| EP (1) | EP0204589B1 (es) |
| JP (1) | JPH0742308B2 (es) |
| KR (1) | KR930005992B1 (es) |
| AT (1) | ATE69238T1 (es) |
| DE (1) | DE3682330D1 (es) |
| ES (1) | ES8707261A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879370A (en) * | 1983-12-02 | 1989-11-07 | Cornell Research Foundation, Inc. | Glutathione delivery system |
| US4968671A (en) * | 1987-11-26 | 1990-11-06 | Yamanouchi Pharmaceutical Co., Ltd. | Therapeutic agents for ischemic heart diseases |
| US4883862A (en) * | 1988-04-13 | 1989-11-28 | Albert Einstein College Of Medicine - Of Yeshiva University | Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same |
| US5110796A (en) * | 1988-12-09 | 1992-05-05 | Yamanouchi Pharmaceutical Co., Ltd. | Prophylactic and therapeutic agents for cataracts |
| US5093478A (en) * | 1989-07-14 | 1992-03-03 | Cornell Research Foundation, Inc. | Preparing glutathione monoesters |
| US5464825A (en) * | 1991-03-14 | 1995-11-07 | Cornell Research Foundation, Inc. | Raising glutathione equivalent levels using N-acyl glutathione monoesters |
| NL9102143A (nl) * | 1991-12-20 | 1993-07-16 | Dsm Nv | Bereiding van oligopeptide- of aminozuur-alkylester. hcl-zouten. |
| WO1994025052A1 (en) * | 1993-05-03 | 1994-11-10 | Cornell Research Foundation, Inc. | Use of glutathione diesters |
| JPH09301996A (ja) * | 1996-05-09 | 1997-11-25 | Kyowa Hakko Kogyo Co Ltd | グルタチオンモノエステルスルホン酸塩 |
| US5780489A (en) * | 1996-08-21 | 1998-07-14 | Brooks; Benjamin Rix | Method for treating amyotrophic lateral sclerosis |
| US5756823A (en) * | 1996-09-05 | 1998-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Glutathione monoester sulfonate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3882097A (en) * | 1969-08-13 | 1975-05-06 | Merck & Co Inc | {60 -Methyl glutathione, analogs thereof, intermediates therefore and processes for their preparation |
-
1986
- 1986-05-30 US US06/869,187 patent/US4709013A/en not_active Expired - Fee Related
- 1986-06-03 JP JP61129468A patent/JPH0742308B2/ja not_active Expired - Lifetime
- 1986-06-05 KR KR1019860004455A patent/KR930005992B1/ko not_active Expired - Fee Related
- 1986-06-06 ES ES555837A patent/ES8707261A1/es not_active Expired
- 1986-06-09 DE DE8686304379T patent/DE3682330D1/de not_active Expired - Fee Related
- 1986-06-09 AT AT86304379T patent/ATE69238T1/de not_active IP Right Cessation
- 1986-06-09 EP EP86304379A patent/EP0204589B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0204589B1 (en) | 1991-11-06 |
| EP0204589A3 (en) | 1988-09-21 |
| ATE69238T1 (de) | 1991-11-15 |
| EP0204589A2 (en) | 1986-12-10 |
| ES8707261A1 (es) | 1987-07-16 |
| JPS6289695A (ja) | 1987-04-24 |
| KR870000355A (ko) | 1987-02-18 |
| DE3682330D1 (de) | 1991-12-12 |
| KR930005992B1 (ko) | 1993-07-01 |
| US4709013A (en) | 1987-11-24 |
| JPH0742308B2 (ja) | 1995-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970505 |