ES8101558A1 - Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas - Google Patents
Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureasInfo
- Publication number
- ES8101558A1 ES8101558A1 ES487159A ES487159A ES8101558A1 ES 8101558 A1 ES8101558 A1 ES 8101558A1 ES 487159 A ES487159 A ES 487159A ES 487159 A ES487159 A ES 487159A ES 8101558 A1 ES8101558 A1 ES 8101558A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazolidinylidene
- ureas
- hypertension
- aryl
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 235000013877 carbamide Nutrition 0.000 title abstract 2
- 208000028774 intestinal disease Diseases 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE N-ARIL-N''-(2-IMIDAZOLIDINILEDEN) UREAS. CONSTA DE LAS SIGUIENTES ETAPAS: 1) CALENTAMIENTO DEL ISOCIANATO Y LA TIOUREA A LA TEMPERATURA DEL BAÑO DE VAPOR DURANTE UN TIEMPO DE 2 A 12 HORAS, FORMANDOSE EL COMPUESTO TIOBIURET. 2) REACCION DEL N-ARIL-TIOBIURET Y UN AGENTE 5-METILANTE PARA PRODUCIR UN N''-(ARILAMINO) CARSONIL CARBAMIMIDOTIATO DE METILO EMPLEANDO UN DISOLVENTE, TAL COMO METANOL, ETANOL O ISOPROPANOL. 3) REACCION DE HIDROYODURO Y UNA ETILENDIAMINA PARA OBTENER LA N-ARIL-N''-IMIDAZOLIDINILI-DENUREA EN FORMA DE HIDROYODURO, LA REACCION SE LLEVA A CABO EN METANOL OTROS ALCANOLES INFERIORES. EL PRODUCTO ES RECUPERADO Y PURIFICADO POR PROCEDIMIENTOS CONVENCIONALES. CONTROL DE LA HIPERTENSION Y ALIVIO DE TRASTORNOS INTESTINALES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/972,579 US4229462A (en) | 1978-12-22 | 1978-12-22 | Method for controlling hypertension and compositions |
| US05/972,580 US4239768A (en) | 1978-12-22 | 1978-12-22 | Method for relieving irritable bowel syndrome symptoms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8101558A1 true ES8101558A1 (es) | 1980-12-16 |
| ES487159A0 ES487159A0 (es) | 1980-12-16 |
Family
ID=27130555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES487159A Granted ES487159A0 (es) | 1978-12-22 | 1979-12-20 | Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas |
Country Status (23)
| Country | Link |
|---|---|
| AT (1) | AT373878B (es) |
| AU (2) | AU532332B2 (es) |
| CA (1) | CA1127651A (es) |
| CH (1) | CH647236A5 (es) |
| DE (1) | DE2951213A1 (es) |
| DK (1) | DK548179A (es) |
| ES (1) | ES487159A0 (es) |
| FI (1) | FI66354C (es) |
| FR (2) | FR2444462B1 (es) |
| GB (2) | GB2040681B (es) |
| GR (1) | GR68018B (es) |
| HU (1) | HU183013B (es) |
| IL (1) | IL59019A (es) |
| IT (1) | IT1126839B (es) |
| NL (1) | NL7909265A (es) |
| NO (1) | NO794249L (es) |
| NZ (1) | NZ192453A (es) |
| PH (1) | PH16571A (es) |
| PT (1) | PT70624A (es) |
| SE (1) | SE7910612L (es) |
| SU (1) | SU971098A3 (es) |
| YU (1) | YU314979A (es) |
| ZW (1) | ZW25379A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673680A (en) * | 1985-09-18 | 1987-06-16 | Pendleton Robert G | α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility |
| US11516649B2 (en) | 2018-10-29 | 2022-11-29 | Apple Inc. | Mechanism to activate and manage a standalone device for cellular service |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1296962A (fr) * | 1960-08-05 | 1962-06-22 | Geigy Ag J R | Nouveaux composés 2-imino-1.3-di-aza et leur préparation |
| NL267923A (es) * | 1960-08-05 |
-
1979
- 1979-12-06 CA CA341,351A patent/CA1127651A/en not_active Expired
- 1979-12-06 GR GR60697A patent/GR68018B/el unknown
- 1979-12-13 AU AU53780/79A patent/AU532332B2/en not_active Ceased
- 1979-12-13 PH PH23413A patent/PH16571A/en unknown
- 1979-12-18 NZ NZ192453A patent/NZ192453A/xx unknown
- 1979-12-19 DE DE19792951213 patent/DE2951213A1/de not_active Ceased
- 1979-12-20 DK DK548179A patent/DK548179A/da not_active Application Discontinuation
- 1979-12-20 ES ES487159A patent/ES487159A0/es active Granted
- 1979-12-21 FR FR7931473A patent/FR2444462B1/fr not_active Expired
- 1979-12-21 FI FI794036A patent/FI66354C/fi not_active IP Right Cessation
- 1979-12-21 NO NO794249A patent/NO794249L/no unknown
- 1979-12-21 YU YU03149/79A patent/YU314979A/xx unknown
- 1979-12-21 ZW ZW253/79A patent/ZW25379A1/xx unknown
- 1979-12-21 HU HU79MA3254A patent/HU183013B/hu unknown
- 1979-12-21 NL NL7909265A patent/NL7909265A/nl not_active Application Discontinuation
- 1979-12-21 PT PT70624A patent/PT70624A/pt unknown
- 1979-12-21 IT IT51164/79A patent/IT1126839B/it active
- 1979-12-21 SE SE7910612A patent/SE7910612L/xx not_active Application Discontinuation
- 1979-12-21 SU SU792860905A patent/SU971098A3/ru active
- 1979-12-21 GB GB7944114A patent/GB2040681B/en not_active Expired
- 1979-12-21 AT AT0808979A patent/AT373878B/de active
- 1979-12-21 IL IL59019A patent/IL59019A/xx unknown
- 1979-12-21 CH CH11419/79A patent/CH647236A5/de not_active IP Right Cessation
-
1980
- 1980-04-04 FR FR8007757A patent/FR2445321B1/fr not_active Expired
-
1982
- 1982-07-26 GB GB08221517A patent/GB2113204B/en not_active Expired
-
1983
- 1983-06-29 AU AU16400/83A patent/AU566013B2/en not_active Expired - Fee Related
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