ES8101576A1 - Un procedimiento para la preparacion de derivados del acido monico - Google Patents
Un procedimiento para la preparacion de derivados del acido monicoInfo
- Publication number
- ES8101576A1 ES8101576A1 ES488136A ES488136A ES8101576A1 ES 8101576 A1 ES8101576 A1 ES 8101576A1 ES 488136 A ES488136 A ES 488136A ES 488136 A ES488136 A ES 488136A ES 8101576 A1 ES8101576 A1 ES 8101576A1
- Authority
- ES
- Spain
- Prior art keywords
- antibacterial
- monic acid
- acid
- derivatives
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IUBMRJVNZLQSHU-FDJBSCRHSA-N monate-a Chemical compound C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(O)=O)OC1 IUBMRJVNZLQSHU-FDJBSCRHSA-N 0.000 title abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- KKMHFUKZHJOMJL-ZDACLCLWSA-N (+)-Pseudomonic acid C Natural products O=C(OCCCCCCCCC(=O)O)/C=C(\C[C@H]1[C@@H](O)[C@H](O)[C@H](C/C=C/[C@H]([C@@H](O)C)C)CO1)/C KKMHFUKZHJOMJL-ZDACLCLWSA-N 0.000 abstract 1
- KKMHFUKZHJOMJL-WZLBZGCNSA-N 9-[(e)-4-[(2s,3r,4r,5s)-3,4-dihydroxy-5-[(e,4r,5s)-5-hydroxy-4-methylhex-2-enyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid Chemical compound C[C@H](O)[C@H](C)\C=C\C[C@H]1CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O KKMHFUKZHJOMJL-WZLBZGCNSA-N 0.000 abstract 1
- 241000204031 Mycoplasma Species 0.000 abstract 1
- KKMHFUKZHJOMJL-UHFFFAOYSA-N Pseudomonic acid C Natural products CC(O)C(C)C=CCC1COC(CC(C)=CC(=O)OCCCCCCCCC(O)=O)C(O)C1O KKMHFUKZHJOMJL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 230000002725 anti-mycoplasma Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002924 oxiranes Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DEL ACIDO MONICO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I), O UNA SAL O ESTER DEL MISMO CON UN COMPUESTO R-CH. SE OBTIENE UN COMPUESTO (II). *FORMULA* AL QUE OPCIONALMENTE SE PUEDEN HACER LAS SIGUIENTES OPERACIONES: 1) FORMAR UNA SAL CUANDO R ES HIDROGENO. 2) ESTERIFICACION CUANDO R ES HIDROGENO O UN ION FORMADOR DE SAL. 3) HIDROLIZAR O TRANSESTERIFICAR EL COMPUESTO CUANDO R ES UN RADICAL FORMADOR DE ESTER. ACTIVIDAD ANTIBACTERIANA Y ANTIMICOPLASTICA. (TRATAMIENTO DE INFECCIONES).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1580778 | 1978-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8101576A1 true ES8101576A1 (es) | 1980-12-16 |
| ES488136A0 ES488136A0 (es) | 1980-12-16 |
Family
ID=10065840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479805A Expired ES479805A1 (es) | 1978-04-21 | 1979-04-20 | Un procedimiento para la preparacion de derivados del acido monico. |
| ES488136A Granted ES488136A0 (es) | 1978-04-21 | 1980-01-31 | Un procedimiento para la preparacion de derivados del acido monico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479805A Expired ES479805A1 (es) | 1978-04-21 | 1979-04-20 | Un procedimiento para la preparacion de derivados del acido monico. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US4248887A (es) |
| EP (1) | EP0005006B1 (es) |
| JP (1) | JPS54141777A (es) |
| AT (1) | AT364460B (es) |
| AU (1) | AU526593B2 (es) |
| CA (1) | CA1119589A (es) |
| DE (1) | DE2960718D1 (es) |
| DK (1) | DK164779A (es) |
| ES (2) | ES479805A1 (es) |
| IE (1) | IE48448B1 (es) |
| ZA (1) | ZA791373B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0045150A1 (en) * | 1980-07-24 | 1982-02-03 | Beecham Group Plc | Antibacterial compounds, processes for their preparation and composititions containing them |
| PT73431B (en) * | 1980-08-02 | 1982-10-08 | Beecham Group Plc | Antibacterial compounds processes for their preparation and compositions containing them |
| US4436751A (en) | 1980-12-31 | 1984-03-13 | Beecham Group Limited | Nitrobenzyl monates antibacterial compounds |
| EP0081325A3 (en) * | 1981-12-09 | 1984-05-23 | Beecham Group Plc | Antibacterial compounds |
| GB9313796D0 (en) * | 1993-07-03 | 1993-08-18 | Smithkline Beecham Plc | Novel bioprocess |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071536A (en) * | 1971-06-12 | 1978-01-31 | Beecham Group Limited | Antibiotics |
| GB1587058A (en) * | 1976-06-15 | 1981-03-25 | Beecham Group Ltd | Oxiranylmethyltetrahydropyran derivatives |
| DE2860724D1 (en) * | 1977-11-01 | 1981-08-27 | Beecham Group Plc | Pseudomonic acid c, pharmaceutically acceptable salts or esters thereof, processes for their preparation and pharmaceutical or veterinary compositions containing them |
-
1979
- 1979-03-12 DE DE7979300371T patent/DE2960718D1/de not_active Expired
- 1979-03-12 EP EP79300371A patent/EP0005006B1/en not_active Expired
- 1979-03-19 US US06/021,712 patent/US4248887A/en not_active Expired - Lifetime
- 1979-03-22 ZA ZA791373A patent/ZA791373B/xx unknown
- 1979-03-23 CA CA000324019A patent/CA1119589A/en not_active Expired
- 1979-04-05 AU AU45776/79A patent/AU526593B2/en not_active Ceased
- 1979-04-18 AT AT0291979A patent/AT364460B/de not_active IP Right Cessation
- 1979-04-20 ES ES479805A patent/ES479805A1/es not_active Expired
- 1979-04-20 JP JP4886979A patent/JPS54141777A/ja active Pending
- 1979-04-20 DK DK164779A patent/DK164779A/da not_active Application Discontinuation
- 1979-08-08 IE IE1314/79A patent/IE48448B1/en unknown
- 1979-10-18 US US06/085,894 patent/US4284570A/en not_active Expired - Lifetime
-
1980
- 1980-01-31 ES ES488136A patent/ES488136A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0005006A2 (en) | 1979-10-31 |
| EP0005006B1 (en) | 1981-09-02 |
| DK164779A (da) | 1979-10-22 |
| JPS54141777A (en) | 1979-11-05 |
| AT364460B (de) | 1981-10-27 |
| CA1119589A (en) | 1982-03-09 |
| ATA291979A (de) | 1981-03-15 |
| ES479805A1 (es) | 1980-08-16 |
| EP0005006A3 (en) | 1979-11-14 |
| IE791314L (en) | 1979-10-21 |
| US4284570A (en) | 1981-08-18 |
| AU4577679A (en) | 1979-10-25 |
| US4248887A (en) | 1981-02-03 |
| ES488136A0 (es) | 1980-12-16 |
| IE48448B1 (en) | 1985-01-23 |
| DE2960718D1 (en) | 1981-11-26 |
| ZA791373B (en) | 1980-04-30 |
| AU526593B2 (en) | 1983-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES477591A1 (es) | Procedimiento para la obtencion de preparados farmaceuticos que contienen un derivado de cefem. | |
| ES8606262A1 (es) | Procedimiento para preparar derivados de pleuromutilina | |
| AU538424B2 (en) | Piperazino phenylindane | |
| ES8801232A1 (es) | Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas. | |
| ES8500931A1 (es) | Procedimiento para la obtencion de acidos quinoloncarboxilicos | |
| ES480721A1 (es) | Un procedimiento para aislar pseudomonato de litio. | |
| ZA806399B (en) | New 2-hydroxyalkyl-3,4,5-trihydroxypiperidine compounds, their production and their medicinal use | |
| ES479805A1 (es) | Un procedimiento para la preparacion de derivados del acido monico. | |
| ATE41146T1 (de) | Irreversible dopamin-b-hydroxylase-inhibitoren. | |
| ES474733A1 (es) | Un procedimiento para la preparacion de derivados del acido pseudomonico. | |
| DE2963010D1 (en) | 3-chloro-6-hydroxy-5-methylbenzoic acid derivatives, corresponding pharmaceutical preparations, growth promoting compositions, the use of the compounds for promoting growth in certain animals and their manufacture | |
| ES480905A1 (es) | Un procedimiento para la preparacion de un tiol acido y sus sales y esteres. | |
| ES8101592A1 (es) | Un procedimiento para la preparacion del acido 7-oxo-1-aza- biciclo (3.2.0)hept-2-en-2-carboxilico | |
| ES466493A1 (es) | Procedimiento de fabricacion de acidos a-aril-a -oxo-isovalericos. | |
| DE3166235D1 (en) | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them | |
| NO841292L (no) | Fremgangsmaate ved fremstilling av nye penemforbindelser | |
| ES8106158A1 (es) | Un procedimiento para la preparacion de una penicilina | |
| ES483463A1 (es) | Procedimiento de preparacion de los esteres del 1-metil-4- piperidinol | |
| EP0144238A3 (en) | A new compound, fr-900451, production and use thereof | |
| ES8100243A1 (es) | Un procedimiento para la preparacion de derivados de acido tro-clorocitrico | |
| GB919205A (en) | Gibberellic acid derivatives | |
| GB1539158A (en) | Process for the preparation of 7-(1,4-dihydro-4-oxo-1-pyridyl)acetamido-cephem derivatives | |
| ES418293A1 (es) | Un procedimiento para la preparacion de agentes antibacte- rianos. | |
| JO1231B1 (en) | A way to treat monocytes | |
| ES418328A1 (es) | Un procedimiento para la preparacion de nuevos derivados deacido 1-acilanidocefalosporanico 3-tiolado. |