ES8801232A1 - Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas. - Google Patents

Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.

Info

Publication number
ES8801232A1
ES8801232A1 ES556748A ES556748A ES8801232A1 ES 8801232 A1 ES8801232 A1 ES 8801232A1 ES 556748 A ES556748 A ES 556748A ES 556748 A ES556748 A ES 556748A ES 8801232 A1 ES8801232 A1 ES 8801232A1
Authority
ES
Spain
Prior art keywords
production
heterocyclic compounds
medicaments containing
compounds
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556748A
Other languages
English (en)
Other versions
ES556748A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES556748A0 publication Critical patent/ES556748A0/es
Publication of ES8801232A1 publication Critical patent/ES8801232A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/16—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO HIDROXI O MERCAPTO, DE FORMULA (II), O UNO DE SUS DERIVADOS SUSTITUIDO CON METAL ALCALINO CON EL COMPUESTO HALOGENADO, DE FORMULA X-A2-R7, PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LAS QUE M REPRESENTA HIDROGENO O METAL ALCALINO, R1 ES ACILO, R2 ES ALQUILO INFERIOR, A Y A2 SON ALQUILENO INFERIOR OPCIONALMENTE SUSTITUIDO CON UN HIDROXILO, HET ES ANILLO HETEROCICLICO Y R4, R5, R7, Y E Y'' PUEDEN SER VARIOS RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE VARIAS ENFERMEDADES ALERGICAS Y TRASTORNOS ISQUEMICOS DEL CORAZON Y DEL CEREBRO.
ES556748A 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas. Expired ES8801232A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23899184 1984-11-12
JP21932785 1985-10-01

Publications (2)

Publication Number Publication Date
ES556748A0 ES556748A0 (es) 1987-12-16
ES8801232A1 true ES8801232A1 (es) 1987-12-16

Family

ID=26523058

Family Applications (9)

Application Number Title Priority Date Filing Date
ES548772A Expired ES8707947A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556748A Expired ES8801232A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxolicas.
ES556753A Expired ES8801189A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES548772A Expired ES8707947A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556749A Expired ES8801233A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556746A Expired ES8801231A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES556753A Expired ES8801189A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556750A Expired ES8801234A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556752A Expired ES8801188A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556747A Expired ES8801187A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
ES556751A Expired ES8801235A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.

Country Status (8)

Country Link
US (2) US4855310A (es)
EP (1) EP0181779B1 (es)
KR (1) KR900004804B1 (es)
AT (1) ATE102930T1 (es)
CA (1) CA1269982A (es)
DE (1) DE3587777T2 (es)
ES (9) ES8707947A1 (es)
PH (1) PH22520A (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61186368A (ja) * 1985-02-14 1986-08-20 Kyorin Pharmaceut Co Ltd 新規な抗アレルギ−薬およびその製造方法
US5180730A (en) * 1985-07-22 1993-01-19 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic compounds
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A
US4942245A (en) * 1987-04-20 1990-07-17 Kyorin Pharmaceutical Co., Ltd. Benzimidazole Derivatives
JPH0667836B2 (ja) * 1989-03-01 1994-08-31 東洋紡績株式会社 アミド系化合物からなる抗アレルギー剤
US5102897A (en) * 1990-03-27 1992-04-07 Warner-Lambert Company 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
DE4035599A1 (de) * 1990-11-06 1992-05-07 Dresden Arzneimittel Neue 5-(phenoxyalkanoylamino)-uracile, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AU6962098A (en) * 1997-04-11 1998-11-11 Eli Lilly And Company Combinatorial libraries of peptidomimetic aminothioether acids
US6492372B1 (en) 1999-01-22 2002-12-10 Elan Pharmaceuticals, Inc. Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2357781A1 (en) 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Multicyclic compounds which inhibit leukocyte adhesion mediated by vla-4
IL143928A0 (en) * 1999-01-22 2002-04-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by vla-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2361162A1 (en) 1999-03-01 2000-09-08 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7-receptor antagonists
US6552073B1 (en) * 2002-03-01 2003-04-22 Exonhit Therapeutics Sa Compounds and methods of treating cell proliferative diseases
TW200307671A (en) * 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) * 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
CA2489355A1 (en) * 2002-06-13 2003-12-24 Qlt Inc. Methods of using isothiazole derivatives to treat cancer or inflammation
NZ567270A (en) * 2005-09-29 2011-06-30 Elan Pharm Inc Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by VLA-4
BRPI0616643A2 (pt) * 2005-09-29 2011-06-28 Elan Pharm Inc compostos de carbamato que inibem a adesão leucocitária mediada por vla-4
KR20080100271A (ko) * 2006-02-27 2008-11-14 엘란 파마슈티칼스, 인크. Ｖｌａ-4에 의해 매개되는 백혈구 부착을 억제하는 피리미디닐 술폰아미드 화합물
EP2424841A1 (en) * 2009-04-27 2012-03-07 Elan Pharmaceuticals Inc. Pyridinone antagonists of alpha-4 integrins
JP6012468B2 (ja) 2009-10-02 2016-10-25 アヴェクシン エーエス 抗炎症性２−オキソチアゾールおよび２−オキソオキサゾール
CN105102438B (zh) 2013-01-29 2019-04-30 埃维克辛公司 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
WO2021055388A1 (en) * 2019-09-17 2021-03-25 The Lubrizol Corporation 2,5-dimercapto-1,3,4-thiadiazole ("dmtd") derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
JPS591268B2 (ja) * 1978-10-18 1984-01-11 興和株式会社 チアジアゾ−ル誘導体
US4411905A (en) * 1979-09-04 1983-10-25 Richardson-Merrell Inc. Antisecretory 1,2,4-triazole-3-thiols
AU554388B2 (en) * 1981-06-15 1986-08-21 American Home Products Corporation Alpha-phenyl-2-(aza)benzothiazolylthioglycolic acid derivatives
DE3270324D1 (en) * 1982-01-22 1986-05-07 Basf Ag Aminothiadiazoles, process for their preparation and their use in combating unwanted plant growth
US4517188A (en) * 1983-05-09 1985-05-14 Mead Johnson & Company 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols
US4672066A (en) * 1985-04-22 1987-06-09 Hoffmann-La Roche Inc. Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acids
US4803211A (en) * 1985-07-22 1989-02-07 Yamanouchi Pharmaceutical Co., Ltd. Thiadizazole compounds as antagonists of SRS-A

Also Published As

Publication number Publication date
ES556751A0 (es) 1987-12-16
ES556753A0 (es) 1987-12-16
ES556749A0 (es) 1987-12-16
ES8801234A1 (es) 1987-12-16
ES8801235A1 (es) 1987-12-16
DE3587777T2 (de) 1994-06-23
US4855310A (en) 1989-08-08
ATE102930T1 (de) 1994-04-15
US4908368A (en) 1990-03-13
KR900004804B1 (ko) 1990-07-06
ES556747A0 (es) 1987-12-16
EP0181779A1 (en) 1986-05-21
ES556752A0 (es) 1987-12-16
EP0181779B1 (en) 1994-03-16
KR860004041A (ko) 1986-06-16
ES548772A0 (es) 1987-09-01
PH22520A (en) 1988-10-17
ES556748A0 (es) 1987-12-16
ES556750A0 (es) 1987-12-16
ES8801187A1 (es) 1987-12-16
ES556746A0 (es) 1987-12-16
ES8801231A1 (es) 1987-12-16
ES8801188A1 (es) 1987-12-16
DE3587777D1 (de) 1994-04-21
CA1269982A (en) 1990-06-05
ES8707947A1 (es) 1987-09-01
ES8801233A1 (es) 1987-12-16
ES8801189A1 (es) 1987-12-16

Similar Documents

Publication Publication Date Title
ES8801235A1 (es) Un procedimiento para la preparacion de acidos 3-hidroxifenoxialquilenheterociclilcarboxilicos.
MY102016A (en) Thiazolidinedione derivatives, their production and use.
HU913283D0 (en) Process for the production of hydroximethyl-(methylene-cyclopentyl)-purines and pirimidines, their medically usable salts, and of medical preparations containing them
HUT43843A (en) Process for production of derivatives of benzimidasole and medical compounds containing thereof
HUT45984A (en) Process for production of quinoline-derivatives and of their medically acceptable acid-additioned salts
DE3476392D1 (en) Purine derivatives
ES552782A0 (es) Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
GR3001195T3 (en) 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans, a process for their preparation and their use as medicaments
ES8304956A1 (es) Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.
EP0399626A3 (en) Substituted tetrahydroisoquinoline compounds, their production, and pharmaceutical compositions containing them
HU912216D0 (en) Process for the production of purinyl-and pirimidinyl - tetrahydrofurane derivatives and medical preparations containing them
AU2013888A (en) Uricosuric composition
ATE51227T1 (de) Chinatsalze der antimalarischen verbindung mefloquin.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001